The invention concerns a control or regulating device with a control or regulating unit, which both controls or regulates a volumetric blood flow flowing through a blood pump as well as a volumetric flow of a gas able to flow through a gas exchange unit.

The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions within a subject and to related methods. More particularly, the invention relates to a cytopheretic cartridge that includes a housing and, disposed within the housing, a solid support capable of sequestering activated leukocytes and/or platelets.

The present disclosure relates to a system for temperature management for patients in stationary and mobile ECLS and/or ECMO therapy, with a disposable and a fluid circuit, wherein the disposable comprises a reservoir or bag provided with at least one supply line and a drain line, further comprising a pumping unit element as part of the disposable, by means of which liquid in the reservoir or bag can be pumped through the fluid circuit, wherein in the mounted state of the system all fluid-guiding parts of the system are completely encapsulated and separated from intracorporeal and extracorporeal blood circuit of the patient undergoing the ECLS and/or ECMO therapy.

A method is for managing accumulation of condensed water in a sweep gas flow path of an oxygenator in an extracorporeal membrane oxygenator [ECMO] device. The method comprises the steps of monitoring a sweep gas flow rate and/or a sweep gas pressure within the sweep gas flow path; determining when a purge condition is met based on the monitored sweep gas flow rate and/or pressure, and performing a water purge manoeuvre when the purge condition is met. The water purge manoeuvre comprises one or more of: activating an automatic purge function of the ECMO device for automatically purging the sweep gas flow path through generation of a purge flow of sweep gas through the sweep gas flow path; causing a recommendation to activate the automated purge function of the ECMO device to be presented to an operator of the ECMO device; causing a recommendation to manually purge the sweep gas flow path to be presented to the operator of the ECMO device, and; generating an alarm indicative of accumulation of water in the sweep gas flow path.

An oxygenator having a plurality of porous hollow fiber membranes for gas exchange to treat blood is manufactured by dissolving a silicone compound in an organic solvent having a surface tension of less than 70 dyn/cm to prepare a coating solution, and bringing an inner surface of the hollow fiber membranes into contact with the coating solution under a negative pressure of 50 hPa or more and 150 hPa or less to form a silicone compound-containing coating layer on the inner surface. An antithrombotic polymer compound-containing coat can be provided directly on an outer surface of the hollow fiber membranes.

A method for controlling carbon dioxide [CO2] removal in a device (5) for extracorporeal blood gas exchange is disclosed. The device (5) comprises an oxygenator (21) including a membrane (23) acting as a gas-liquid barrier enabling CO2 transfer between a bloodstream and a sweep gas flow through the oxygenator. The method comprises the steps of adding (S1) CO2 to the sweep gas flow upstream of the oxygenator (21) to control a degree of CO2 removal from the bloodstream by the oxygenator, determining (S2) a measure of CO2 removal by the oxygenator (21) based on a difference [CCO2.sub.blood] between a measure of a pre-oxygenator content of CO2 [CCO2.sub.in] in the bloodstream upstream of the oxygenator (21) and an estimate of a post-oxygenator content of CO2 [CCO2.sub.out] in the bloodstream downstream of the oxygenator (21), and utilizing (S3) the measure of CO2 removal for improved regulation of the CO2 addition to the sweep gas flow.

Perfusion systems and methods are provided for increasing peripheral blood flow to reduce limb ischemia, in which an extracorporeal pump having a controller, and catheter/tubing set, employed alone or in conjunction with an interventional or circulatory assist device, withdraws blood from a patient's vasculature and reintroduces that blood at another location within the patient's vasculature at a controlled local pressure or flow rate, without interfering with operation of the interventional or circulatory assist device or surgical intervention.

A method is for patient body temperature control during gas exchange treatment of a patient, such as extracorporeal membrane oxygenator [ECMO] treatment provided by an ECMO device and/or respiratory treatment provided by a mechanical ventilator. The method comprises the steps of determining a gas exchange being at least one of a carbon dioxide [CO2] exchange and an oxygen [O2] exchange between an oxygen-containing gas and blood of the patient; inducing a change in temperature of the patient; detecting a change in the gas exchange following the change in the temperature of the patient, and automatically controlling the temperature of the patient based on the detected change in gas exchange, and/or presenting a recommendation for manual adjustment of the temperature of the patient to a user, based on the detected change in gas exchange.

The disclosure relates to devices and methods for extracorporeal conditioning of blood. Extracorporeal blood oxygenators and blood oxygenator components, such as conditioning modules, are described. An extracorporeal blood oxygenator includes a conditioning module having an external frame, an inlet cover, an outlet cover, and an internal chamber. A fiber assembly is disposed within the internal chamber and a potting material on the fiber assembly creates a circumferential seal that defines a passageway through the fiber assembly having a substantially circular cross-sectional shape. A fluid inlet is in fluid communication with the passageway, has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly, and has an internal curvilinear surface adjacent the fiber assembly. A fluid outlet on the opposite side of the fiber assembly also has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly.

The present disclosure describes intravascular oxygenation systems and methods with one or more of improved oxygen diffusion flux, improved resistance to bubble formation on the surface of non-porous hollow fibers, and reduced size. The systems and methods include a pneumatic inlet coupled to a pneumatic source that provides a gas containing oxygen at a high pressure. A plurality of hollow fiber membranes (HFM) are in pneumatic communication with the pneumatic inlet to receive the gas containing oxygen and with an outlet to exhaust a partially deoxygenated gas. An electronic controller drives the motor to oscillate the plurality of HFMs to cause a diffusive flux of the gas containing oxygen from the plurality of HFMs into a region of interest of a subject. The electronic controller may drive the motor according to an oscillation pattern, which may include a macro-oscillation with superimposed micro-oscillations.