A separation module that includes a porous membrane, where the porous membrane includes a poly(phenylene ether) copolymer containing 10 to 40 mole percent repeat units derived from 2-methyl-6-phenylphenol and 60 to 90 mole percent repeat units derived from 2,6-dimethylphenol; and a block copolymer containing backbone or pendant blocks of poly(C.sub.2-4 alkylene oxide). The separation module can be used in devices for wastewater treatment, water purification, desalination, separating water-insoluble oil from oil-containing wastewater, membrane distillation, sugar purification, protein concentration, enzyme recovery, dialysis, liver dialysis, or blood oxygenation.

A transportable extracorporeal system includes a housing, a blood flow inlet, a blood flow outlet, a plurality of hollow gas permeable fibers, a gas inlet in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with outlets of the plurality of hollow gas permeable fibers, a first moving element, a concentrated oxygen generating device, a second moving element, a hollow transport conduit having a proximal opening and a distal opening and a power source configured to provide power to the first and second moving elements. The plurality of hollow gas permeable fibers comprising a gas transfer membrane. The concentrated oxygen generating device is configured to recycle waste oxygen from the gas transfer membrane to increase throughput and remove, by an adsorption/desorption process, unwanted gasses.

According to some embodiments, a system may treat blood outside the body of a patient. The system may include at least one toxin removal system configured to process blood from at least two places on the patient's body at a rate, for example, of at least 0.5 liters per minute. The system may be configured to raise the pH level of the patient's blood by introducing a fluid at rate of at least 9 liters per hour.

A device containing transplanted tissue includes a housing, having a chamber configured for insertion into a body of a subject and protecting the transplanted tissue from the subject's immune system. The housing includes an oxygen supply container, a hydrogel layer, a port, and an access port. The oxygen supply container has a chamber defined by top and bottom surfaces and sides, disposed within the chamber of the housing. The top surface and the bottom surface of the oxygen supply container include a gas-permeable membrane. The hydrogel layer has inner and outer surfaces. The inner surface of the hydrogel layer contacts the top surface of the oxygen supply container or the bottom surface of the oxygen supply container. The port is configured to deliver oxygen to the oxygen supply container. The access port is configured to receive an exogenous supply of gas and is fluidly connected to the port.

The present disclosure concerns embodiments of multi-lumen cannulae that can be used in various different medical procedures. The multi-lumen cannulae can comprise an elongated body comprising multiple different ports that connect to the various different sidewall lumens contained within the elongated body. The multi-lumen cannulae can also comprise a central lumen that extends through the entire elongated body and can be fluidly connected to the various different sidewall lumens. The multi-lumen cannulae can further comprise two balloons on the exterior of the elongated body, which can be used to isolate the right atrium of a patient's heart.

The present invention relates to an extracorporeal circuit for CO.sub.2 removal from blood comprising a line for taking blood from the patient, a decarboxylation assembly and a line for returning the blood to the patient; said decarboxylation assembly comprising a first filtering unit, an oxygenator, an electrodialyzer adapted to generate an acid solution and a basic solution and means for the infusion of said acid solution upstream of said oxygenator, wherein said electrodialyzer comprises a first electrodialysis chamber and a second electrodialysis chamber, said first and second electrodialysis chambers being separated by an ionic membrane, and in that wherein said first chamber and said second chamber are respectively separated from the positive electrode, or anode, and from the negative electrode, or cathode, by means of a bipolar membrane.

An artificial heart and lung apparatus includes a roller pump; a blood removal line; a first blood transfer line; a blood removal rate sensor; a control unit that performs the linked control of the roller pump in correspondence with a blood removal rate; and a blood transfer rate adjustment unit that instructs the roller pump to transfer a blood transfer rate. The blood transfer rate adjustment unit includes an operation amount input unit to which an operation amount from an arbitrary circumferential position can be input, and which outputs a pulse signal according to the input operation amount. A counter adds and subtracts pulse signals output from the operation amount input unit, and outputs a resultant as blood transfer rate adjustment data. The counter performs a counting operation with respect to the circumferential position of the operation amount input unit when blood transfer control transitions to the normal control.

A method of controlling thermal transfer in a perfusion system heat exchanger of an extracorporeal fluid treatment device for conditioning an extracorporeal patient fluid for administration to a patient comprises a step of providing a perfusion system heat exchanger, wherein the perfusion system heat exchanger comprises a first fluid passage for a liquid heat transfer medium and a second fluid passage for the extracorporeal patient fluid to be temperature-controlled via exchange of thermal energy with the heat transfer medium, and a step of providing the heat transfer medium through the first fluid passage. The heat transfer medium comprises a component with anti-microbial properties, such as glycol. The provision of antimicrobial fluid reduces the risk of microbe contamination of the extracorporeal fluid, and hence the risk of clinical complications.

An improved system and methods for treatment of cancer and other diseases including complications from late-stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed. The method can also be effective in treating rheumatoid arthritis, scleroderma, hepatitis, sepsis, the Epstein-Barr virus, and patients with life threatening complications from other viruses, including the COVID-19 virus. A method for removing viruses from the blood supply in an external circuit is also presented. An adjunct of the present invention is enhanced production of stem cells as a result of employing the HEATT process. A further adjunct is production of transgenic swine with extant viral infections.

A system and method for reducing gas bubbles, including gaseous microemboli (GME) during cardiopulmonary bypass (CPB) by the use of an oxygenator with venous blood bypass and a filter in the venous blood bypass is provided.