The present disclosure relates to systems and methods for the separation of blood into blood products and, more particularly, to systems and methods that permit automated recovery of white blood cells after producing a leukocyte-reduced blood product.

A dialysis machine has a blood circuit, a blood pump, a dialyzer, a venous pressure sensor, a substituate line, and a control unit. The control unit can operate the blood pump in a first operating mode and in a special operating mode, and start the special operating mode after a trigger event. In the special operating mode, a blood pump conveying rate is controlled via a default value or regulated to a desired value, with the default or desired value being derived from a value determined before the started special mode or corresponding to the value. The presence of an obstacle is polled before the special mode, and depending on the presence thereof, the start of the special mode is blocked or delayed and/or the selection of the default value or the desired value on the presence of the obstacle differs from the selection without the presence of the obstacle.

The invention relates to fluid flow paths and fluid connectors for use with detachable containers that can be seated in an infusate caddy for use in a dialysis machine. The detachable containers can contain infusates or other solutes or materials such as disinfectants or cleaners, and can be conveniently seated in the infusate caddy. The detachable containers can be removed from the infusate caddy for restocking, cleaning, or resupply, as needed. The infusate caddy can be positioned or seated in a receiving compartment of a dialysis machine, and can also be removed, as needed. The fluid path and fluid connectors of the present invention provide the required fluid fittings, valve arrangements, pumps, and paddle assemblies for using the infusate caddy.

A portable adapter is provided that can include a closure system configured to control the flow of blood and/or dialysate between the adapter and a blood treatment apparatus. Modular systems are also provided that include the portable adapter engaged with various units such as a portable blood processing module, a non-portable base module, and/or a remote module. Methods of conducting blood treatments such as blood circulation, hemodialysis, and hemofiltration, hemodiafiltration, using the modular systems are also provided. The systems, units, and methods enable the engagement and disengagement of the adapter from the various units to conduct, interrupt, and resume blood treatments without disconnecting the adapter from the vasculature of a patient. Modular systems including interchangeable portable and base modules configured for various blood treatments are also provided that can be engaged and disengaged with each other without disconnecting the portable module from the vasculature of a patient.

A fluid extraction implantable system shaped and sized to be implanted in a patient, including: a fluid extraction chamber having a flat and thin shape connected to a draining tube and including at least one external flat surface, wherein the at least one external flat surface is configured to be attached to a tissue surface when a negative pressure is applied on the draining tube, wherein the chamber extracts fluids from the tissue by applying the negative pressure through the flat surface on the attached tissue surface.

A blood treatment device includes an extracorporeal blood circuit, dialyzer and dialysis fluid circuit. The blood circuit and dialysis fluid circuit are separated from each other by a membrane in the dialyzer. A weighing device measures and monitors the weight of a bag containing a fluid. A fluid pump pumps fluid out of and into the bag. A control unit interrupts fluid supply by stopping the pump when a weight variation of the bag occurs and temporarily maintains the interruption at least until the malfunction disappears, and automatically restarts the fluid supply if the bag or the weight of the bag stabilizes within a predetermined time and the weight variation does not exceed a predetermined value. The control unit generates an alarm if the bag or weight of the bag does not stabilize within a predetermined time and/or if the weight variation exceeds a predetermined value.

A blood treatment device includes an extracorporeal blood circuit, a dialyzer and a dialysis fluid circuit. The extracorporeal blood circuit has an arterial portion, a venous portion, an air detector configured to monitor whether air is present in the venous portion, at least one blood pump configured to pump blood through the extracorporeal blood circuit, a venous hose clamp configured to selectively clamp or release the venous portion, a user interface, and a control unit. When the control unit receives information from the air detector that there is air in the venous portion, the control unit is configured to stop the blood pump, close the venous hose clamp, raise an alarm, and display on the user interface instructions for removing air in the venous portion and displaying status reports about the removal of air, and carry out automatic removal of air from the venous portion on a user-initiated basis.

This disclosure relates to dialysis systems and methods. In some implementations, a dialysis system includes a dialysis machine with a fluid line and a drain line, a blood line set configured to be connected to the dialysis machine, and a drain apparatus coupled to the dialysis machine. The drain apparatus includes a chamber configured to receive an end of a patient line of the blood line set, an inlet line, an outlet line, and a valve. The inlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the fluid line of the dialysis machine. The outlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the drain line of the dialysis machine. The valve is configured to control flow of fluid through the outlet line.

Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.

Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.