The invention relates to an apparatus for exchanging material between blood and a gas/gas mixture, comprising a chamber (1) through which blood can flow and in which a plurality of material-permeable fiber tubes is provided, the gas/gas mixture being flowable through the fiber tubes, blood being flowable around the fiber tubes. At least one deformable element (9) is provided in the chamber (1) in addition to the fiber tubes, through which the gas/gas mixture can flow, this deformable element being deformable and restorable, in particular compressible out of a relaxed shape and restorable to a relaxed shape by pressure fluctuations acting on the at least one element (9) externally, in particular pressure fluctuations transmitted by the blood in the chamber (1).

Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.

Extracorporeal blood treatment systems and methods to detect the connection of one or more components (e.g., of an extracorporeal blood set) thereto (e.g., to one or more pressure transducers contained in the system housing) by, for example, controlling an air pump apparatus to provide air to a connection port at which the component is to be connected and monitoring pressure resulting therefrom to detect whether the component is operatively connected (e.g., based on a detected change in the monitored pressure due to the increased resistance, based on a monitored rate of decay of pressure of injected air, etc.).

A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition.

A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition.

A medical fluid management assembly includes a pneumatic manifold, a pump and valve engine, and a fluid manifold. The pneumatic manifold includes a plurality of pneumatic passageways and a plurality of pneumatic connectors. The pump and valve engine includes a plurality of valve chambers, at least one pump chamber, and a plurality of pneumatic connectors mated sealingly and releasably with the pneumatic connectors of the pneumatic manifold. The pump and valve engine also includes a plurality of fluid connectors. The fluid manifold includes a plurality of fluid pathways and a plurality of fluid connectors mated sealingly and releasably with the fluid connectors of the pump and valve engine.

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

In one aspect, a valve includes a valve body rotatable about a central axis of the valve body, an interior channel adjacent the valve body for permitting a fluid to flow through an axial opening of the interior channel, and a plug within the interior channel that is movable between a first axial position at the axial opening and a second axial position spaced apart from the axial opening. In the first axial position, the plug closes the axial opening to prevent the fluid from flowing through the axial opening in a first direction and to prevent the fluid from flowing through the axial opening in a second direction that is opposite to the first direction. In the second axial position, the plug permits the fluid to flow through the axial opening into the interior channel in the first direction.

This disclosure relates to dialysis systems and methods. In some implementations, a dialysis system includes a dialysis machine with a fluid line and a drain line, a blood line set configured to be connected to the dialysis machine, and a drain apparatus coupled to the dialysis machine. The drain apparatus includes a chamber configured to receive an end of a patient line of the blood line set, an inlet line, an outlet line, and a valve. The inlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the fluid line of the dialysis machine. The outlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the drain line of the dialysis machine. The valve is configured to control flow of fluid through the outlet line.

A dual lumen drainage cannula configured for use in a VA ECMO system includes a first drainage tube having a proximal end, a distal end, and at least one aperture in at least one wall of the first drainage tube proximate to the distal end of the first drainage tube, and a second drainage tube having a proximal end, a distal end, and at least one aperture in at least one wall of the second drainage tube proximate to the distal end of the second drainage tube. The first drainage tube passes through the second drainage tube. The dual lumen drainage cannula also includes a sleeve positioned adjacent to an interior wall of the second drainage tube. The sleeve is formed of a flexible material so as to be expandable and collapsible within the second drainage tube.