A dialysis system includes a disposable cassette including a flexible sheet and a plurality of dialysis fluid pathways, a plurality of actuators operable with the flexible sheet to direct dialysis fluid through the plurality of dialysis fluid pathways, and a controller configured to (i) determine at least one limitation of the plurality of dialysis fluid pathways, (ii) generate a flow schedule indicating how dialysis fluid should be directed through the plurality of dialysis fluid pathways in accordance with the at least one limitation, and (iii) control the plurality of actuators so that dialysis fluid is pumped through the plurality of dialysis fluid pathways according to the flow schedule.

A method of determining a system compressibility value of a medical membrane pump drive is provided which includes moving to a first and second pressure level and detecting a first and second operating parameter value of the membrane pump drive. The system compressibility value is determined on the basis of the detected operating parameter values and the membrane of the membrane pump drive is supported at a rigid surface during the determination of the system compressibility value.

Devices, systems, and methods can be used to deliver temperature-controlled medical fluids to patients. For example, this disclosure provides devices, systems, and methods for controlling the temperature of dialysate delivered to a patient during a peritoneal dialysis treatment.

A medical fluid delivery cassette configured for use with a medical fluid pumping system and related systems and methods. The medical fluid delivery cassette includes a base and a membrane that together define a fluid pump chamber. The medical fluid delivery cassette further includes a member configured to apply an outward force to an inner surface of the membrane.

A peritoneal dialysis system includes a cycler including a pump actuator, a heater and a heating pan operable with the heater, and a disposable set operable with the cycler. The heating pan includes a sidewall forming a slot. The disposable set includes a pumping cassette and a heater/mixing container. The pumping cassette includes a pump chamber configured to be actuated by the pump actuator. Additionally, the heater/mixing container is in fluid communication with the pumping cassette and is sized to be received at the heating pan. The heater/mixing container includes a port configured such that when the port is slid into the slot of the heater pan sidewall, the port is prevented from rotating about an axis transverse to a direction of flow through the port.

An example peritoneal dialysis system is disclosed. The example peritoneal dialysis system includes at least one pump and a memory device configured to store therapy prescriptions including a low ultrafiltration (UF) therapy prescription, a first standard UF therapy prescription with a longer duration and a lower dextrose concentration, and a second standard UF therapy prescription with a shorter duration and a higher dextrose concentration. The memory device also stores a schedule indicative as to which of the therapy prescriptions are to be performed on specified dates. The system further includes a logic implementer configured to determine or identify a current date, use the schedule stored in the memory device to select the therapy prescription based on the current date, and control the at least one pump based on the selected therapy prescription to perform a peritoneal dialysis therapy.

A peritoneal dialysis (PD) system includes a cycler having a peristaltic pump actuator; a disposable set including a pressure sensing manifold including first and second pressure sensing pods, a drain line and a first dialysis fluid/heater container line in fluid communication with the first pressure sensing pod, and at least one dialysis fluid container line and a patient line in fluid communication with the second pressure sensing pod; and a control unit programmed to operate the peristaltic pump actuator (i) in a first direction to pump fresh dialysis fluid along the at least one additional dialysis fluid container line into the first dialysis fluid/heater line and (ii) in a second direction to pump heated fresh dialysis fluid along the first dialysis fluid/heater line into the patient line. The pump actuator may be operated in the first direction again to pump used dialysis fluid from the patient to a drain.

A manifold assembly for a peritoneal dialysis apparatus, comprises: a casing delimiting internally a first compartment and a second compartment; a yielding pump tube having a first end connected or connectable to the first compartment and a second end connected or connectable to the second compartment. The yielding pump tube extends outside the casing to be coupled to a peristaltic pump of a cycler of a peritoneal dialysis apparatus. A first pump port and a second pump port are placed on a first side of the casing and ports are placed on a second side of the casing, opposite the first side.

A manifold assembly for a peritoneal dialysis apparatus, comprises: a casing delimiting internally a first compartment and a second compartment; a yielding pump tube having a first end connected or connectable to the first compartment and a second end connected or connectable to the second compartment. The yielding pump tubes extends outside the casing to be coupled to a peristaltic pump of a cycler of a peritoneal dialysis apparatus. The second compartment delimits expansion chambers configured to attenuate pressure pulsations from the peristaltic pump.

A method for calibrating a peristaltic pump in a medical apparatus comprises: rotating the peristaltic pump of a predetermined rotation to pump a liquid from a fluid source from a first compartment into a second compartment of a manifold assembly, raising a level of the liquid in the second compartment and compressing air in an air buffer volume of the manifold assembly; measuring a pressure of air in the air buffer volume; calculating, from the measured pressure, a variation of liquid volume in the second compartment due to the rotation of the peristaltic pump; calculating, from the variation of liquid volume and the predetermined rotation, a stroke liquid volume of the peristaltic pump.