Dialysis systems and methods for operating dialysis machines (e.g., peritoneal dialysis machines) for conducting dialysis treatments are disclosed. The dialysis system may include a dialysis machine for transferring dialysate to a patient from a dialysate source. The dialysate may flow from the dialysate source through a cassette (e.g., a disposable cassette) positionable within a port formed in the dialysis machine. The dialysis system may also include a cleaning cartridge insertable into the port. The cleaning cartridge may be arranged and configured to collect, remove, etc. any foreign material or debris from the port.

A method is provided for detecting leaks in a disposable medical fluid cassette that includes a base and a flexible membrane attached to the base in such a way that the base and the flexible membrane cooperate to at least partially form a fluid passageway. The method includes applying a first force to the flexible membrane, measuring a first physical property of a system that includes the medical fluid cassette a medical fluid pumping machine, removing the first force from the flexible membrane, applying a second force to the flexible membrane, measuring a second physical property of the system, and determining whether the medical fluid cassette leaks based on a comparison of the first physical property and the second physical property.

A home therapy machine is configured to perform a home therapy on a patient at a home or dwelling of the patient. The home therapy machine includes at least one processor operating a connectivity agent having an activated mode and a deactivated mode. When the connectivity agent is in the activated mode, the at least one processor is able to send data to and receive data from a system hub. When the connectivity agent is in the deactivated mode, the at least one processor is not able to send data to or receive data from the system hub. The home therapy machine further includes a user interface configured to receive a patient selection of a device program received from the system hub and at least one pump under control of the at least one processor for performing the home therapy according to the selected device program.

In examples described herein, a catheter configured to deliver dialysate and extract an effluent fluid from a peritoneal cavity of a patient includes at least two sensors configured and positioned to generate respective signals indicative of one or more parameters related to PD treatment provided to the patient. The sensors can include, for example, a pressure sensor configured to generate a pressure signal indicative of a pressure of a fluid within a lumen of the catheter or external to the catheter and an impedance sensor configured to generate an impedance signal indicative of an impedance of a fluid within the lumen of the catheter or external to the catheter. A parameter related to PD treatment can include, for example, a catheter status or a peritoneal cavity status of the patient.

A medical infusion fluid handling system, such as an automated peritoneal dialysis system, may be arranged to de-cap and connect one or more lines (such as solution lines) with one or more spikes or other connection ports on a fluid handling cassette. This feature may reduce a likelihood of contamination since no human interaction is required to de-cap and connect the one or more lines and the one or more spikes. For example, the automated peritoneal dialysis system may include a carriage arranged to receive the one or more lines each having a connector end and a cap. The carriage may move along a first direction so as to move the connector ends of the one or more lines along the first direction, and a cap stripper may be arranged to engage with the caps on the the one or more lines on the carriage. The cap stripper may move in a second direction transverse to the first direction, as well as to move with the carriage along the first direction.

A peritoneal dialysis system includes a cycler including a pump actuator, a heater and a heating pan operable with the heater, and a disposable set operable with the cycler. The heating pan includes a sidewall forming a slot. The disposable set includes a pumping cassette and a heater/mixing container. The pumping cassette includes a pump chamber configured to be actuated by the pump actuator. Additionally, the heater/mixing container is in fluid communication with the pumping cassette and is sized to be received at the heating pan. The heater/mixing container includes a port configured such that when the port is slid into the slot of the heater pan sidewall, the port is prevented from rotating about an axis transverse to a direction of flow through the port.

The present disclosure provides methods and systems for treating a biological fluid of a subject suffering from a microbial infection (e.g., a drug-resistant microbial infection). In some embodiments, these methods and systems involve a complement receptor immobilized on, or otherwise associated with a polymer substrate, for example, high surface area particles, membranes, hollow fibers, and/or other porous or non-porous media. In other embodiments, the methods and systems involve a complement receptor present in a dialysate used in a dialyzer for extracting pathogens out of a biological fluid, for example, the blood of a patient.

The invention relates to an apparatus for carrying out a peritoneal dialysis treatment comprising a reservoir for fresh dialysis fluid, a connector for connecting to a peritoneal catheter of a patient, a drain for consumed dialysis fluid, and a control unit connected to actuators, wherein the apparatus is configured to carry out a plurality of consecutive inflow-dwell-outflow cycles for a treatment on the basis of a prescription stored in the control unit, in which inflow-dwell-outflow cycles dialysis fluid is supplied to the patient from the reservoir and is led off through the outflow again after the elapse of a specific dwell time in the peritoneum of the patient, and wherein the apparatus is further configured to already replace a portion of the dialysis fluid present in the peritoneum of the patient with fresh dialysis fluid from the reservoir before the elapse of the dwell time in at least one cycle if, in at least one preceding cycle, the volume of fresh dialysis fluid provided in accordance with the prescription for this preceding cycle was not completely consumed.

A secure artificial intelligence (AI) enabled wearable medical sensor platform is used for adaptive operation according to features and techniques described herein. Operational parameters are modified based on data inputs thereto that provide feedback to the AI systems of the wearable sensor platform. The described technology can facilitate adaptive optimizations provided by AI machine learning algorithms in a manner that can beneficially assist in the monitoring and treatment of a patient. For example, the system described herein may be used for the continuous monitoring of the physiological parameters and health of a patient's vascular access point (for example, the fistula) and may provide, among other things, early warnings of possible infection at the vascular access location.

A treatment device system includes a treatment machine for generating custom peritoneal dialysis solution and including at least one fluid conveyor, the treatment machine having a controller, the controller having a first memory, configured to produce a therapeutic fluid by causing the at least one fluid conveyor to mix purified water and at least one concentrate. The system also includes a user interface and a water purifier in fluid communication with and providing the purified water to the treatment machine, the water purifier including internal central controller, the internal central controller having a second memory, to control preparation of the purified water. A server is communicatively coupled with the treatment machine and a control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier.