A virtual reality (VR), augmented reality (AR) and/or mixed reality (MR) system in a physical environment with a plurality of loudspeakers includes a user-worn head mounted display (HMD), a VR/AR/MR processor, and a VR/AR/MR user tracking processor. The HMD includes a microphone and a user tracking device configured to track a user orientation and position. The VR/AR/MR processor delivers a digital video signal to the head-mounted display, and a digital control signal and a digital audio signal to a receiver/preamplifier. The VR/AR/MR user tracking processor receives user tracking data from the HMD user tracking device and provides a digital user tracking data signal to the receiver preamplifier. the receiver/preamplifier receives the digital user tracking data signal, the digital control signal, the digitized microphone signal, and the digital audio signal, and provides a processed audio signal to the amplifier. An amplifier receives the processed audio signal and provides amplified audio signals.

Systems and methods for adjusting bass levels of a multi-channel audio signal include, among other features, (i) receiving the multi-channel signal via a playback device; (ii) separating, from the multi-channel signal, low-frequency signals comprising frequencies less than a threshold frequency; (iii) determining electrical energies of the low-frequency signals; (iv) determining a first energy by summing the electrical energies of the low-frequency signals; (v) consolidating the low-frequency signals into a consolidated low-frequency signal; (vi) determining a second energy by determining an electrical energy of the consolidated low-frequency signal; (vii) generating a gain-adjusted low-frequency signal by adjusting a gain of the consolidated low-frequency signal based on both (a) the first energy and (b) the second energy; (viii) generating a gain-adjusted multi-channel signal by mixing the gain-adjusted low-frequency signal back into the multi-channel signal; and (ix) using the gain-adjusted multi-channel signal to play back gain-adjusted multi-channel audio content via the playback device.

Example embodiments may include one or more of receiving sound emissions signals from channels via sound emitters, controlling the sound emission signals, via relay circuits, and one of the relay circuits is configured to interrupt one of the sound emission signals associated with one of the sound emitters while the other sound emissions signals pass to the other corresponding sound emitters, and receiving, via a sound detection circuit, an electrical ambient sound signal based on ambient sound sensed by the one of the sound emitters responsive to the interrupted one of the sound emission signals.

Provided herein, in some aspects, are compositions and methods for treating Barth syndrome (BTHS) using human tafazzin gene therapy or enzyme replacement therapy. The present disclosure, in some aspects, provides compositions and methods (e.g., gene therapy or enzyme replacement therapy) for treating Barth syndrome (BTHS). It was demonstrated herein that certain human Tafazzin (hTAZ) isoforms and the full length protein, as well as nucleic acids encoding them, are effective in treating BTHS.

A method, apparatus and computer program are provided for assessing a continuity of audio service by comparing a previous audio service with a first spatial audio service that uses user head-tracking and a second audio service to identify which of the first or second spatial audio service provides a continuity of audio service with respect to the previous audio service. If the first or second spatial audio service is assessed to provide continuity of audio service, the respective spatial audio service is selectively enabled. The first spatial audio service controls or sets at least one directional property of at least one sound source and the first spatial audio service is assessed to provide continuity of audio service if it can use head-tracking to control or set the at least one directional property of at least one sound source.

An electronic device is provided. The electronic device includes a plurality of audio output devices and at least one processor operatively connected to the plurality of audio output devices, wherein the at least one processor may be configured to identify orientation information of the electronic device, based on detecting an output of audio data, transmit, to each audio output device, channel information of audio data to be output by each of the plurality of audio output devices, based on the orientation information of the electronic device, and control the plurality of audio output devices so that each audio output device selects a channel and outputs audio data of the selected channel, based on the channel information.

A display apparatus is disclosed. The display apparatus includes a display, a speaker, and a processor configured to acquire location information of the display apparatus inside a modular display apparatus including a plurality of display apparatuses, change an output set value of the speaker based on the location information, and control the speaker to output a sound signal received from an external apparatus based on the changed output set value, wherein the external apparatus includes at least one of another display apparatus adjacent to the display apparatus among the plurality of display apparatuses or a source apparatus.

Implementations of the subject technology provide for audio integration of portable electronic devices into enclosed environments. A portable electronic device may be carried, by a user, into an enclosed environment, such as into an enclosure of a building, a room, or other apparatus. One or more remote speakers may be disposed in the enclosed environment. The remote speaker(s) may be operated in cooperation with the portable electronic device to spatially coordinate audio output from the remote speaker(s) with video content displayed by the portable electronic device.

A content output device includes at least one processor and at least one communicator. The at least one communicator is configured to output a plurality of channels from the at least one processor to a plurality of audio devices signals. When the number of audio devices increases and at least one additional channel is available to be reproduced, the assigning task assigns the at least one additional channel to the increased number of audio devices and the outputting task outputs the at least one additional channel in accordance with the changed assignment of the plurality of channels.

An auditory wearable device management system for supporting effective use of an auditory wearable device shared by a collection of people (hereinafter abbreviated as an auditory device) is provided. An auditory wearable device management system for distributing audio information from one or more information sound sources to an auditory device worn by each wearer constituting a collection of people and acting collectively includes wearing information holding means that associates the wearer with a wearing status of the auditory device worn by the wearer as wearing information, audio information distribution control means that outputs distribution control information for designating the wearer, the wearer being a distribution destination of the audio information from each of the one or more information sound sources.