An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for receiving a desired sodium mass transport at the end of the treatment session and for setting the sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point to achieve the desired sodium mass transport at the end of the treatment session.

An artificial kidney configured to automatically or semi-automatically perform priming, procedure running, purging, flushing, and procedure ending. The artificial kidney is wearable and can be used while ambulating, sitting, and lying down. The artificial kidney can be used at home as a supplement to standard intermittent hemodialysis therapy in the clinic. In an example, the artificial kidney can be configured to perform alert event detection, start a timer, and take steps to resolving the alert event. The steps can include automated steps and can include instructions to be manually performed by the user (or the patient). If the alert event is resolved within a set time, the artificial kidney can continue to perform procedure running. If the alert event is not resolved within the set time, the artificial kidney performs the procedure ending.

The disclosure relates to a blood treatment device for use in blood treatment therapies, comprising: an extracorporeal blood circuit, a dialyzer and a dialysis fluid circuit, wherein the extracorporeal blood circuit and the dialysis fluid circuit are separated from each other via a membrane provided in the dialyzer, via which blood can be filtered; at least one substitution solution pump, which is configured to supply a substitution solution to the extracorporeal blood circuit before and/or after the dialyzer; an effluent pressure sensor, which is configured to measure a pressure in the dialysis fluid circuit after the dialyzer, and a control unit, which is configured to automatically reduce a flow rate of the at least one substitution solution pump when an effluent pressure measured by the effluent pressure sensor drops during an ongoing blood treatment therapy.

A modular assembly for a portable hemodialysis system may include a dialysis unit, e.g., that contains suitable components for performing hemodialysis, such as a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer, and a power unit having a housing that contains suitable components for providing operating power to the pumps of the dialysis unit. The power unit may be selectively connected to the dialysis unit and provide power (e.g., pneumatic power in the form of pressure and/or to vacuum) to the dialysis unit for the pumps when connected to the dialysis unit, but may be incapable of providing power to the dialysis unit when disconnected from the dialysis unit. The dialysis unit and the power unit are sized and weighted to each be carried by hand by a human.

An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32); a control unit (12) is configured for calculating a sodium concentration value for the blood; the estimation of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the isoconductive sodium concentrate and of an offset contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate and phosphate.

An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.

A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

A biological fluid sampling device for collecting a blood sample from a separate vascular access device and for ejecting a portion of the collected sample to a point-of-care testing device for analysis is provided. The biological fluid sampling device includes a body enclosing a reservoir. The reservoir has an internal volume sufficient to contain enough blood for use in a diagnostic test. The sampling device further includes: an access lumen extending from a distal end of the body for establishing fluid communication between a separate vascular access device and the reservoir; an outflow lumen also in fluid communication with the reservoir; and a removable vented cap attached to the outflow lumen including a gas permeable vent in gaseous communication between the reservoir and ambient air. In addition, several sample and transfer devices are provided for obtaining a sample from a subject and transferring the sample to a point-of-care testing device.

The present invention relates to an apparatus for an extracorporeal blood treatment having an extracorporeal blood circuit in which a dialyzer is arranged and having a dialyzate circuit, wherein the blood circuit is in fluid communication with a first chamber and the dialyzate circuit is in fluid communication with a second chamber of the dialyzer, and wherein the two chambers are separated from one another by a semipermeable membrane, with a dialyzate pump for a conveying of the dialysis solution being present in the dialyzate circuit, wherein the apparatus has a control unit that is configured to operate the apparatus in a first phase and in a second phase following the first phase, wherein the dialyzate pump is operated with a smaller flow rate in the first phase than in the second phase and/or wherein the dialyzate pump conveys a dialysis solution in the first phase that is of a higher concentration with respect to at least one component than in the second phase.

Dialysis is enhanced by using nanoclay sorbents to better absorb body wastes in a flow-through system. The nanoclay sorbents, using montmorillonite, bentonite, and other clays, absorb significantly more ammonium, phosphate, and creatinine, and the like, than conventional sorbents. The montmorillonite, the bentonite, and the other clays may be used in wearable systems, in which a dialysis fluid is circulated through a filter with the nanoclay sorbents. Waste products are absorbed by the montmorillonite, the bentonite, and the other clays and the dialysis fluid is recycled to a patient's peritoneum. Using an ion-exchange capability of the montmorillonite, the bentonite, and the other clays, waste ions in the dialysis fluid are replaced with desirable ions, such as calcium, magnesium, and bicarbonate. The nanoclay sorbents are also useful for refreshing a dialysis fluid used in hemodialysis and thus reducing a quantity of the dialysis fluid needed for the hemodialysis.