An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32); a control unit (12) is configured for calculating a sodium concentration value for the blood; the estimation of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the isoconductive sodium concentrate and of an offset contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate and phosphate.

A biological fluid collection device that is adapted to receive a blood sample having a cellular portion and a plasma portion is disclosed. After collecting the blood sample, the biological fluid collection device is able to transfer the blood sample to a point-of-care testing device or a biological fluid separation and testing device. After transferring the blood sample, the biological fluid separation and testing device is able to separate the plasma portion from the cellular portion and analyze the blood sample and obtain test results.

A biological fluid sampling transfer device adapted to receive a multi-component blood sample is disclosed. After collecting the blood sample, the biological fluid sampling transfer device is able to separate a plasma portion from a cellular portion. After separation, the biological fluid sampling transfer device is able to transfer the plasma portion of the blood sample to a point-of-care testing device. The biological fluid sampling transfer device also provides a closed sampling and transfer system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer. The biological fluid sampling transfer device is engageable with a blood testing device for closed transfer of a portion of the plasma portion from the biological fluid sampling transfer device to the blood testing device. The blood testing device is adapted to receive the plasma portion to analyze the blood sample and obtain test results.

An enclosure for containing a portable hemodialysis unit includes a housing suitable to support components for performing hemodialysis including a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer. The housing may have a front panel at which blood circuit connections and dialysate fluidic connections are located, e.g., blood line connections for patient blood access, connections for a reagent supply, dialyzer connections for both blood flow and dialysate, etc. The enclosure may also include a pair of vertical, side-by-side doors hingedly mounted to the housing. With the doors in the closed position, access to the patient access and dialysate fluidic connections may be blocked, and the doors may allow for the retention of heat in the housing suitable for disinfection during a disinfection cycle.

Provided is a biological fluid-treating filter for treating a biological fluid containing erythrocytes, which has a matrix and a polymer retained by the matrix, the polymer having a zwitterion-containing functional group and a basic nitrogen-containing functional group. By using the filter in which the polymer has the zwitterion-containing functional group and the basic nitrogen-containing functional group, it is possible to treat the biological fluid containing erythrocytes without adversely affecting the erythrocytes.

A hemodialysis device and method are provided in which a hemodialyzer is designed for blood to flow past a semipermeable membrane and for a dialysate to flow in the opposite direction on the other side of the semipermeable membrane where uremic solutes are capable of diffusing from the blood into the dialysate passing the semipermeable membrane, and further designed in which a sorbent incorporated in a dialysate path as the dialysate passes the semipermeable membrane. The sorbent binds to non-urea uremic solutes and in particular to non-urea uremic solutes that bind to plasma proteins. In addition, the sorbent binds urea and inorganic ions much less effectively than non-urea uremic solutes and in particular to non-urea uremic solutes that bind to plasma proteins.

The invention relates to systems and methods for optimizing a peritoneal dialysate prescription based on one or more fluid characteristics sensed from a filtrate removed from a patient. The systems and methods include sensors, flow paths, and processors to adjust a peritoneal dialysate prescription and deliver peritoneal dialysis therapy to a patient based on the adjusted prescription. The method can include the steps of removing fluid from a peritoneal cavity of a patient; sampling one or more characteristics of the removed fluid; and adjusting a peritoneal dialysate prescription based on the one or more characteristics of the removed fluid. The system can include a peritoneal dialysate effluent line; at least one concentrate source fluidly connectable to the peritoneal dialysate flow path; and at least one sensor positioned in the peritoneal dialysate effluent line.

A crossflow filter includes a rigid cylindrical inner wall and a rigid cylindrical outer wall inner with an inelastic filter membrane positioned therebetween defining a retentate channel inside the filter membrane and a permeate channel outside the filter membrane. Further, the filter includes transition channels shaped and connected to the inner and outer walls to deliver a flow of fluid from an inlet port to the retentate channel and to capture flow flowing longitudinally along the cylindrical inner and outer walls from both the retentate and permeate channels to respective outlet ports.

The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface, a heater in thermal communication with the planar surface, and a sodium sensor in electromagnetic communication with the planar surface. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features.

A dialysis system is disclosed. The dialysis system includes a water purification unit, at least one pump in fluid communication with the water purification unit, a first concentrate source for creating peritoneal dialysis fluid, a second concentrate source for creating blood treatment dialysis fluid, a blood filter for receiving the blood treatment dialysis fluid, and a control unit. The control unit controls the at least one pump to perform a peritoneal dialysis treatment by delivering, to a patient, peritoneal dialysis fluid that is mixed from the water and concentrate from the first concentrate source. The control unit also controls the at least one pump to perform a blood treatment by delivering, to the blood filter, blood treatment dialysis fluid that is mixed from the water and concentrate from the second concentrate source.