An apparatus for isolating stems cells from extracted mammalian tissue comprising: a portable hollow casing having fixed dimensions and a sized internal spatial volume; a filter housed and contained within said sized internal spatial volume, wherein said filter captures particles in said extracted mammalian tissue having a diameter of about 5 to 10 microns or more and allows particles in said extracted mammalian tissue having a diameter of less than about 5 to 10 microns to pass through; a first channel to which a container holding said extracted mammalian tissue can attach, and through which said extracted mammalian tissue is input into the hollow casing; wherein a stem cell collection chamber can attach to said first channel, and the particles having a diameter of about 5 to 10 microns or more are output from the hollow casing through said first channel and collected in the stem cell collection chamber; and a second channel to which a remnant collection chamber can attach, and through which the particles having a diameter of less than about 5 to 10 microns are output from the hollow casing and collected in the remnant collection chamber.

A combination kidney and liver dialysis system and method provides a portable, lightweight hemodialysis device that removes uremic toxins, hepatic toxins, water, and impurities from the blood. The method comprises separating the blood into a plasma portion and a cellular portion, immediately returning the cellular portion to the body, providing large volumes of replacement fluids, diluting the plasma portion with replacement fluids, and then manipulating the plasma portion of the blood to pass through hemoperfusion membranes, hemodiafiltration membranes, and extracorporeal membrane oxygenation membranes. Dialysis is performed on the plasma portion of the blood with an albumin dialyzer against an albumin dialysate and a high molecular weight cut off membrane. Dialysis is performed on the plasma portion of blood with a lipid dialysate comprising 10-30% lipid composition, and a high flux dialyzer. The system can also use any form of dialysis technology including hollow fiber, flat plate and microfluidic technology.

A method for a hybrid blood and peritoneal dialysis (PD) machine comprising: (i) determining whether a previous treatment left a last fill of dialysate in a patient's peritoneum; (ii) if a next treatment is a PD treatment, and if the previous treatment did not leave the last fill of dialysate, causing a PD treatment in which a first cycle is a fill cycle to be initiated; (iii) if the next treatment is a PD treatment, and if the previous treatment did leave the last fill of dialysate, causing a PD treatment in which a first cycle is a last fill drain cycle to be initiated; and (iv) if the next treatment is a blood treatment and if the previous treatment did leave the last fill of dialysate, causing a blood treatment including a last fill drain cycle to be initiated.

A renal failure therapy machine includes a blood cleaning filter, a dialysis fluid circuit including a balance chamber, the balance chamber including a fresh dialysis fluid compartment configured to send fresh dialysis fluid to the blood cleaning filter and a used dialysis fluid compartment configured to receive used dialysis fluid from the blood cleaning filter, a fresh dialysis fluid line in fluid communication with the fresh dialysis fluid compartment of the balance chamber and the blood cleaning filter, and a flow restrictor in fluid communication with the blood cleaning filter, the flow restrictor configured to cause fresh dialysis fluid delivered from the fresh dialysis fluid compartment, through the fresh dialysis fluid line, to the blood cleaning filter to be pressurized so that a first amount of the fresh dialysis fluid performs convective clearance and a second amount of the fresh dialysis fluid performs diffusive clearance.

Provided is a multi-functional filter including a first filter and a second filter to purify a biological fluid, a housing defining an adsorption section outside of the first filter and the second filter, a flow partitioning connector connecting the first filter and the second filter, and a housing port allowing a fluid to flow through the adsorption section. The housing may comprise a wall, a first cap coupled to the first filter at one end of the wall along a longitudinal direction, and a second cap coupled to the second filter at the other end of the wall along a longitudinal direction. The multi-functional filter according to the present invention in which dialysis, adsorption, and plasma separation or ultrafiltration are integrated to purify blood or dialysate and the internal flow is facilitated may provide a blood purifying apparatus that simplifies the whole apparatus, provides convenience in installation and use, and reduces a treatment cost.

A hybrid hemodialysis (HD)/peritoneal dialysis (PD) system includes: a reservoir; a weigh scale operably coupled with the reservoir; and at least one controller programmed to run (i) an HD treatment in which blood is pumped to a blood compartment of a dialyzer, fresh HD dialysis fluid is pumped to a dialysis fluid compartment of the dialyzer, and used HD dialysis fluid is pumped from the dialysis fluid compartment of the dialyzer to the reservoir, and at a different time (ii) a PD treatment in which fresh PD dialysis fluid is pumped to a patient and used PD dialysis fluid is pumped from the patient to the reservoir.

There is provided a bioreactor device having cells, including human primary proximal tubule cells (HPTCs) or HPTC-like cells on the exterior surface of hollow fiber membranes included within the device. Also provided are bioartificial kidney devices incorporate the bioreactor device and methods of using such devices.

A dialysis system includes a dialysis machine configured to control fluid loss or ultrafiltration (UF) volume over a treatment; a graphical user interface (GUI) that allows selection of a prescription entry for the treatment; and a processor operating with the GUI, the processor programmed to (i) receive a plurality of prescription entries via a local or wide area mode of data communication, each prescription entry including at least one prescribed parameter for operating the dialysis machine to control the fluid loss or UF volume, and (ii) enable an operator to choose between the prescription entries provided at the GUI, and select one of the prescription entries for the treatment.

In some examples, a filtration assembly for hemodiafiltration therapy includes a filtration body connector configured to removably mechanically connect the filtration assembly and a dialyzer. In examples, the filtration assembly is configured to remain substantially stationary relative to the dialyzer when the filtration assembly mechanically mates with the dialyzer. The filtration body connector is configured to removably mechanically connect the filtration assembly with a plurality of different types of dialyzers, which may be selected based on a prescription for a particular patient.

A dialysis machine with machine-internal fluidics for dialysis fluid and a housing that at least partially encapsulates the fluidics, wherein the fluidics comprise an input line for fresh dialysis fluid to a dialyzer and an output line for used dialysis fluid from the dialyzer, each line equipped at their end sides with a connection port for a releasably coupling with the dialyzer, wherein the port of the input line and the port of the output line are each formed as a coupling integrated into the housing.