Disclosed is a hemofiltration device, system and method for rapid solute removal from a patient's blood. The device, and method employ a hemofiltration assembly for a high blood flow extracorporeal circuit, such as an ECMO circuit, configured to achieve high-efficiency, high-flux convective solute clearance, and optionally diffusive solute clearance, and include one or more hemofilters having greater filter medium surface area in a circuit having greater flow rates than previously implemented RRT modalities, and may offer rapid clearance of toxins, including those not currently dialyzable (e.g., those with high volumes of distribution).

A dialysis system is provided that includes a dialysis machine and a potassium sensing device that is configured to measure the concentration of potassium in the patient's blood, in spent dialysate resulting from treating the patient, or in both. The potassium sensing device can be configured to generate a sensed value of the concentration of potassium. A control and computing unit, including a processor and a memory, is configured to receive the sensed value, compare the value with one or more values stored in the memory, and generate a control signal based on the comparison. A potassium infusion circuit uses the control signal to infuse supplemental potassium solution into the treatment dialysate, a replacement fluid, or both. The memory can include stored patient-historical and population data.

The present invention relates to an insert piece for a blood tubing set that includes a first connection site for connecting a first tubing portion of the blood tubing set to the insert piece; a second connection site for connecting a second tubing portion of the blood tubing set to the insert piece; a third connection site for connecting a third tubing portion of the blood tubing set to the insert piece; a first main line for conducting a first liquid through the insert piece; a second main line for conducting the first liquid through the insert piece; a secondary line for conducting a second liquid into at least one of the first main line, and the second main line; and a connection portion which connects both main lines to each other or to the second connection site.

A dialysate-extracting apparatus in which a collecting port can be disinfected with no disinfecting work to be performed by a worker. A dialysate-extracting apparatus includes a dialysate-extracting device having an introduction port and a discharge port each of which is connected to the flow route for liquid and allows the liquid to flow therethrough, and a collecting port from which the liquid flowing in the flow route is collectable; and an opening-and-closing device that is movable between a closing position where the opening-and-closing device covers the collecting port of the dialysate-extracting device and an opening position where the opening-and-closing device 6 opens the collecting port. The dialysate-extracting apparatus further includes an ultraviolet-applying device attached to the opening-and-closing device and that is capable of applying ultraviolet rays to the collecting port when the opening-and-closing device is at the closing position.

The present specification describes a modular, portable hemofiltration system, for providing improved clearance levels of blood toxins, which includes at least one roller pump that is designed and operated to generate a rapidly varying pressure profile of fluid within at least a blood circuit of the hemofiltration system.

Systems and methods for performing therapeutic plasma exchange are provided. The systems and methods utilize a plasmapheresis device that includes a controller that is configured and/or programmed to monitor the amount plasma collected and initiate delivery of a therapeutic agent.

Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.

The present invention provides a method for hemodiafiltration which applies dialysate gradient across a multi-chambered hemodiafiltrator having a plurality of compartmentalized tubular dialysate chambers. An acidic dialysate with urea at a concentration is applied to a first dialysate chamber. A less acidic dialysate with a lower concentration of urea than those for the first dialysate chamber is applied to a second dialysate chamber. A basic dialysate with no urea but with ammonia at a concentration up to a concentration detected in normal human blood is applied to a last dialysate chamber. The concentrations of urea for the first and second dialysate chambers decrease over time to zero prior to conclusion of hemodiafiltration.

The present invention provides a method for hemodiafiltration which applies dialysate gradient across a multi-chambered hemodiafiltrator having a plurality of compartmentalized tubular dialysate chambers. An acidic dialysate with urea at a concentration is applied to a first dialysate chamber. A less acidic dialysate with a lower concentration of urea than those for the first dialysate chamber is applied to a second dialysate chamber. A basic dialysate with no urea but with ammonia at a concentration up to a concentration detected in normal human blood is applied to a last dialysate chamber. The concentrations of urea for the first and second dialysate chambers decrease over time to zero prior to conclusion of hemodiafiltration.

A blood treatment system employing at least two pumps for performing a low blood flow treatment is operable for high blood flow treatments such as extracorporeal membrane oxygenation (ECMO) by providing a fluid circuit with parallel blood flow paths and recruiting multiple ones of the pumps for parallel blood flow.