This disclosure relates to a method for determining a fluid balance between a first volume flow in a first section of a fluid circuit and a second volume flow of a second section of the fluid circuit. The method may also include adjusting, assuming or detecting a first temperature in the first section of the fluid circuit and a second temperature in the second section of the fluid circuit, or detecting a temperature difference between the first and the second sections. The method may also include detecting a second volume flow in a second section of the fluid circuit and forming a balance from at least the first volume flow and a corrected value of the second volume flow. The corrected value is determined from the detected second volume flow and the second temperature and/or the temperature difference.

An extracorporeal blood treatment apparatus (1) comprising a control unit (10) connectable to a blood warming device (200). The apparatus (1) comprises: an extracorporeal blood circuit (100) and at least one infusion line (15, 21, 25) connected to the extracorporeal blood circuit (100). A control unit (10) is configured to execute the following procedure: receiving a first value representative of a desired blood temperature (T.sub.des) at an end (70) of a blood return line (7) configured to be connected to a venous vascular access of a patient (P); receiving at least a first signal relating to at least a flow rate (Q.sub.PBP, Q.sub.REP1, Q.sub.REP2) of an infusion fluid in the at least one infusion line (15, 21, 25); calculating a set point value of an operating parameter (T.sub.OUT; P.sub.w) to be imposed on the warming device (200) configured to heat a blood heating zone (H) of the extracorporeal blood circuit (100) in order to maintain the desired blood temperature (T.sub.des) at the end (70) of the blood return line (7). The set point is calculated based on input parameters comprising: at least the first value representative of the desired blood temperature (T.sub.des) and at least one selected in the group of: the first signal (Q.sub.REP1, Q.sub.PBP, Q.sub.REP2) and a second value representative of a temperature (T.sub.REP1, T.sub.PBP, T.sub.REP2) of the at least one infusion fluid in the at least one infusion line (15, 21, 25).

A method for filling and venting a device for extracorporeal blood treatment is disclosed, such as a patient module in a heart-lung machine, without attached patient. A filling liquid from a filling liquid container located higher than the device flows by gravity via a venous side of the system into a reservoir and flows onwards into a blood pump located at the lower end of the reservoir, wherein a first controllable valve (HC1) for a venting line of a filter is opened and, after the response of an upper filling level sensor in the reservoir, is closed. An upper level of the filter is positioned higher than the upper filling level sensor, and a start-stop motion of the blood pump is performed, as a result of which a stepped flooding of the filter is made providing for an advantageous de-airing of the device.

A hollow-fiber-type blood processing device and methods for its manufacture include a hollow fiber membrane bundle which is obtained by bundling a large number of hollow fiber membranes into a columnar shape. A sheet body is mounted on an outer peripheral portion of the hollow fiber membrane bundle. The sheet body is expandable as a result of being woven from a sheet material. An inner diameter of the sheet body in a natural state where no external force is applied to the sheet body is smaller than the outer diameter of the hollow fiber membrane bundle.

A microfluidic photoreactor for treating excess bilirubin in blood, having: a microfluidic channel module; an illumination module comprising one or more illumination sources disposed about the microfluidic channel module and configured to illuminate blood passing through at least one microfluidic channel of the microfluidic channel module; and a heat exchanger module coupled to the at least one microfluidic channel module, wherein the heat exchanger module is configured to extract heat from the at least one microfluidic channel. A system including a microfluidic photoreactor and a method of treating excess bilirubin in blood.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Multiple embodiments of medical filters are described. For example, this document describes extracorporeal blood filters that have a gradient of filter pore sizes at different portions of the filter element. The gradient of filter pore sizes may enhance the filter's potential for capturing and removing gaseous bubbles that may be present in the blood or other fluid that is flowing through the filter.

An apparatus, system, and method for contacting blood with ozone to kill microorganisms in the blood are described. The method involves injecting microbubbles of ozone containing gas into a flow of blood, preferably at a temperature of less than 12° C. The apparatus includes a blood flow conduit including a blood ozone contacting portion including a porous ozone injector.

Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.

The invention relates to an oxygenator with a housing wall, defining a housing chamber with a blood inlet and a blood outlet, a gas inlet and a gas outlet, and also with a heating element which is arranged in the oxygenator between the blood inlet and blood outlet in order to control the temperature of the blood flowing through the housing chamber. The oxygenator also comprises an electric connection and the heating element has an electric resistor which is designed as a wire. The invention also relates to a method for controlling the heat emission at the heating element of an oxygenator by measuring the flow of blood through the oxygenator and the power of a pump influencing the flow, with the heating power being adjusted in accordance therewith.