A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.

An apparatus, system, and method for contacting blood with ozone to kill microorganisms in the blood are described. The method involves injecting microbubbles of ozone containing gas into a flow of blood, preferably at a temperature of less than 12° C. The apparatus includes a blood flow conduit including a blood ozone contacting portion including a porous ozone injector.

A cell washing apparatus is provided to wash a cell-containing fluid. The apparatus is arranged to exchange one or more exchangeable entities from a cell-containing first fluid, and comprises, a first fluid conduit and a second fluid conduit, the second fluid conduit separated from the first fluid conduit by a semi-permeable membrane disposed therebetween; the first fluid conduit having a first fluid inlet and a first fluid outlet, the first fluid conduit arranged to transport the first fluid in a first direction between the first fluid inlet and the first fluid outlet; the second fluid conduit being arranged to house a second fluid; wherein the semi-permeable membrane comprises a plurality of pores arranged to permit transport of said one or more exchangeable entities from the first fluid to the second fluid; wherein the one or more exchangeable entities comprise free haemoglobin and/or blood plasma; and wherein the first fluid is whole blood isolated from a human body, or packed red blood cells. The cell washing apparatus of the present invention aims to solve the problem of harmful species that accumulate in a cell-containing fluid (such as, for example, transfusion blood) during storage and other applications, in which it is desired to transfer red blood cells to a clean suspending liquid.

Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.

An embodiment includes a cardioplegia delivery system having a console, controller, and disposables. The system aides the perfusionist in cardioplegia delivery to the patient during Cardiopulmonary Bypass Surgery. The console, in conjunction with the disposables, combines blood from the heart-lung machine and crystalloid from the IV-bag in a specified ratio and then adds in a drug (arrest agent and/or additive). The electro-mechanical console incorporates a blood/crystalloid pump, temperature controllable water circulation system, pressure and temperature monitors, a sensor interface with the disposables, an arrest agent pump, an additive pump and ultra-sonic air detection sensors. The system monitors and controls the blood-crystalloid ratio, drug concentration, flow rate, pressure, temperature, and delivery route of the cardioplegia solution delivered to the patient. The system is a software-controlled system with a graphical user interface controller. The controller is utilized to initiate/stop cardioplegia delivery, monitor delivery parameters and view/save relevant case information and data.

A blood pumping device comprising at least a first pump and a second pump, and a first and second pump actuating means for inducing a blood flow in a body's circulatory system is disclosed. Each pump comprises one upper chamber having an inlet channel and one lower chamber having an outlet channel. The upper and lower chambers are separated by a movable valve plane provided with a valve. The pump actuating means are configured to apply a movement to said valve plane in an upward and downward direction between said upper and lower chambers in response to control signals from a control unit, such that when said valve plane moves in an upward direction the valve provided in the valve plane is in an open position allowing a flow of blood from the upper chamber to the lower chamber, and when the valve plane moves in a downward direction the valve is in the closed position and blood is ejected from the lower chamber through the outlet channel. The bottom part of the lower chamber is provided with a bag-like portion.

An artificial heart and lung apparatus includes a roller pump; a blood removal line; a first blood transfer line; a blood removal rate sensor; a control unit that performs the linked control of the roller pump in correspondence with a blood removal rate; and a blood transfer rate adjustment unit that instructs the roller pump to transfer a blood transfer rate. The blood transfer rate adjustment unit includes an operation amount input unit to which an operation amount from an arbitrary circumferential position can be input, and which outputs a pulse signal according to the input operation amount. A counter adds and subtracts pulse signals output from the operation amount input unit, and outputs a resultant as blood transfer rate adjustment data. The counter performs a counting operation with respect to the circumferential position of the operation amount input unit when blood transfer control transitions to the normal control.

A method of controlling thermal transfer in a perfusion system heat exchanger of an extracorporeal fluid treatment device for conditioning an extracorporeal patient fluid for administration to a patient comprises a step of providing a perfusion system heat exchanger, wherein the perfusion system heat exchanger comprises a first fluid passage for a liquid heat transfer medium and a second fluid passage for the extracorporeal patient fluid to be temperature-controlled via exchange of thermal energy with the heat transfer medium, and a step of providing the heat transfer medium through the first fluid passage. The heat transfer medium comprises a component with anti-microbial properties, such as glycol. The provision of antimicrobial fluid reduces the risk of microbe contamination of the extracorporeal fluid, and hence the risk of clinical complications.

A system and method for reducing gas bubbles, including gaseous microemboli (GME) during cardiopulmonary bypass (CPB) by the use of an oxygenator with venous blood bypass and a filter in the venous blood bypass is provided.

A portable medical apparatus for cardiopulmonary aid to patients includes a transportable machine body that integrates an heater/cooler unit and an extracorporeal circuit for circulating the blood of a patient. The extracorporeal circuit includes a line for drawing venous blood from the patient, a line for returning arterial blood to the patient, a pumping unit for pumping blood along the extracorporeal circuit, a heat exchanger for thermoregulating blood in the extracorporeal circuit, and an oxygenator unit for blood oxygenation.