Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

Systems, devices, and method for gas removal from a wearable device are provided. The systems comprise a gas removal filter having an inlet, a fluid outlet, and a vent port. The gas removal filter comprises a filter mesh between the inlet and outlet, the filter mesh configured to allow only liquid phase material through the filter mesh. The systems also comprises a gas detector for detecting gas in the gas removal filter; a orientation sensor for determining an orientation of the gas removal filter; a transducer protector filter having a first side and a second side, the transducer protector filter on fluid communication with the vent port of the gas removal filter; a pressure transducer in fluid communication with the second side of the transducer protector filter; and an gas removal pump in fluid communication with the second side of the transducer protector filter.

A system includes a fluid source storing a fluid and a fluid line coupled to the fluid source and configured to pass the fluid therethrough. The system includes a bubble detector coupled to the fluid line downstream of the fluid source, the bubble detector configured to detect bubbles present in the fluid and to generate a bubble detection signal. The system also includes a valve coupled to the fluid line downstream of the fluid source, the valve configured to switch between a first configuration and a second configuration, where in the first configuration the valve directs the fluid through the fluid line and in the second configuration the valve directs the fluid through a drain line. The system further includes a controller coupled to the bubble detector and the valve, the controller configured to receive the bubble detection signal and to control the valve based on the bubble detection signal.

A hemodialyzer includes a housing, a hollow fiber membrane, a first cap, a second cap and a hydrophilic material . The hollow fiber membrane is disposed in the housing. The first cap is disposed on a blood inlet end of the housing and the second cap is disposed on a blood outlet end of the housing, wherein the blood inlet end is opposite to the blood outlet end. The hydrophilic material is formed on an inner surface of at least one of the first cap and the second cap.

In one aspect, a method and system for detecting a change in fluid dynamics of a fluid flowing through an extra-corporeal circuit is disclosed, which includes establishing an acoustic wave resonance across a transverse dimension of at least a portion of a line associated with the extra-corporeal circuit through which the fluid flows, monitoring a phase signal of the resonant acoustic wave, and identifying occurrence of a change in fluid dynamics of the flowing fluid when the observed phase signal of the resonant acoustic wave indicates a deviation from the expected fluid flow signature. The change in fluid dynamics can be used to indicate a venous needle dislodgement event.

A medical fluid management assembly includes a pneumatic manifold, a pump engine, a valve engine, and a fluid manifold. The pneumatic manifold includes a plurality of pneumatic passageways and a plurality of pneumatic connectors. The pump engine includes a pump chamber and the valve engine includes a valve chamber. Each of the pump engine and valve engine includes a pneumatic connector mated sealingly and releaseably with one of the pneumatic connectors of the pneumatic manifold. Additionally, each of the pump engine and valve engine includes a fluid connector. The fluid manifold includes a plurality of fluid pathways and a plurality of fluid connectors mated sealingly and releaseably with the fluid connectors of the pump engine and the valve engine.

An artificial kidney configured to automatically or semi-automatically perform priming, procedure running, purging, flushing, and procedure ending. The artificial kidney is wearable and can be used while ambulating, sitting, and lying down. The artificial kidney can be used at home as a supplement to standard intermittent hemodialysis therapy in the clinic. In an example, the artificial kidney can be configured to perform alert event detection, start a timer, and take steps to resolving the alert event. The steps can include automated steps and can include instructions to be manually performed by the user (or the patient). If the alert event is resolved within a set time, the artificial kidney can continue to perform procedure running. If the alert event is not resolved within the set time, the artificial kidney performs the procedure ending.

Described are fluid pumping and fluid handling systems, which may be suitable for use in medical devices, such as artificial or extracorporeal blood pumping systems. The systems can include a dual housing configuration for pneumatic actuation comprising a main housing containing a pump cassette comprising a pneumatically actuated pump and pneumatically actuated valves. The pump can include a pump actuation chamber and pump pneumatic port, and the valves can each include a valve actuation chamber and valve pneumatic port. Connecting tubes can be used to fluidly connect the pump actuation ports and valve actuation ports to a tube-support housing having a first side receiving one end of each connecting tube and a second side providing a pneumatic interface arranged to connect to an array of pneumatic receptacles on a base unit of the system to facilitate easy, compact and accurate pneumatic interconnection between the pump cassette and the base unit.

A customizable and intuitive user interface for medical systems and devices, such as cardiopulmonary bypass systems, perfusion systems, extracorporeal circulation apparatuses, and heart-lung machines, is provided, which allows for ease of access to critical patient data to facilitate blood perfusion and to monitor and regulate various physiological parameters of a patient and an extracorporeal blood flow circuit during surgical procedures, such as cardiopulmonary bypass and extracorporeal membrane oxygenation (ECMO).

A blood treatment system and method controlling same are provided. The system comprises a blood pump for urging blood from an arterial or venous interface through a blood flow path; a dialyser in fluid communication with said blood flow path for ultrafiltering the blood to remove fluid therefrom; a fluid removal pump in fluid communication with said dialyser for urging ultrafiltered fluid away from said dialyser; a controller in signal communication with said blood pump; and a reversing valve for selectively reversing direction of blood flow in at least a portion of the blood flow path under signal control of said controller. The blood pump is selectively activatable under signal control of the controller.