The present invention relates to an apparatus for a pressure-based detection of a clot in an extracorporeal blood circuit, wherein the apparatus comprises at least one cyclically operating pump for conveying the fluid located in the extracorporeal circuit and at least one pressure sensor which is arranged to determine the current pressure development over time in the fluid conveyed by the pump in a current conveying cycle of the pump, wherein the apparatus has at least one memory in which at least one reference pressure development is stored which is based on at least one pressure development over time which was determined in a conveying cycle of the pump preceding the current conveying cycle of the pump, and wherein the apparatus comprises at least one evaluation unit which is configured such that it compares the current pressure development with the reference pressure development over a corresponding time.

A dialysis device having an extracorporeal blood circuit which has an arterial line having a blood pump and an arterial needle for connection to a patient, a venous line having a venous needle for connection to a patient and a dialyzer arranged between the arterial line and the venous line and having a blood chamber and a dialysis fluid chamber is provided. The dialysis device furthermore has a control unit and an extracorporeal blood pressure sensor which is arranged at the suction side of the blood pump. The control unit is configured such that a signal output takes place which indicates the presence of recirculation when a change in the signal of the sensor following a trigger event exceeds a threshold value.

A device and method are described for the treatment of blood, which device may be used in conjunction with or in place of a failed Kidney. The device includes an ultrafiltration unit to remove proteins, red and white blood cells and other high molecular weight components, a nanofiltration unit to remove glucose, at least one electrodeionization unit to transport ions from the blood stream, and a reverse osmosis unit to modulate the flow of water, to both the blood and urine streams. In one embodiment, a specialized electrodeionization unit is provided having multiple chambers defining multiple dilute fluid channels, each channel filled with an ion specific resin wafer, and electrodes at the extremity of the device and proximate each of the resin filled dilute channels. By selective application of voltages to these electrodes, the ion transport functionality of a given dilute channel can be turned on or off.

A pressure detector that includes a case connectable to a flow route for liquid, and a membrane member attached inside the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion, the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion. The pressure detector includes an inlet port including a connecting portion connectable to the flow route for the liquid, and a flow-route portion through which the liquid flows into an inlet opening of the liquid-phase portion; and an outlet port including a connecting portion connectable to the flow route for the liquid, and a flow-route portion through which the liquid having flowed into the liquid-phase portion is discharged from an outlet opening. At least one of the flow-route portion of the inlet port and the flow-route portion of the outlet port is configured such that an incoming direction or an outgoing direction of the liquid is inclined with respect to an attaching plane defined for the membrane member.

A pressure detector including a case connectable to a flow route and attachable to a predetermined attaching surface; and a membrane member attached inside the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion, the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion. The pressure detector includes an inlet port including a connecting portion connectable to the flow route, and a flow-route portion through which the liquid flows into an inlet opening of the liquid-phase portion; and an outlet port including a connecting portion connectable to the flow route, and a flow-route portion through which the liquid having flowed into the liquid-phase portion is discharged from an outlet opening. The outlet opening is positioned in a part of the liquid-phase portion that includes a highest point in a vertical direction in a state where the case is attached to the predetermined attaching surface, and the outlet port extends obliquely upward from the outlet opening.

A blood purification apparatus that accurately calculates the colloid osmotic pressure of a patient's blood. A dialyzer included in the blood purification apparatus has thereinside blood flow routes and dialysate flow routes that are separated from each other by hollow fibers. An ultrafiltration pump draws out water from the blood in the blood flow routes through the hollow fibers into the dialysate flow routes. Four detecting units measure the pressures of liquid flowing into the blood flow routes, the liquid discharged from the blood flow routes, dialysate flowing into the dialysate flow routes, and the dialysate discharged from the dialysate flow routes. The pressures at the four positions, the transmembrane pressure difference can be calculated. The blood flow routes are filled with a priming solution, and the transmembrane pressure difference (TMPa) is measured. Subsequently, the blood flow routes are filled with the patient's blood, and the transmembrane pressure difference (TMPb) is measured. Referencing TMPa and TMPb, the colloid osmotic pressure of the patient's blood can be calculated. Referencing colloid osmotic pressure, the plasma total protein can be calculated. Referencing plasma total protein, the patient's state of nutrition can be estimated.

A blood purification apparatus including a blood circuit including an arterial blood circuit and a venous blood circuit and that allows a patient's blood to extracorporeally circulate from a distal end of the arterial blood circuit to a distal end of the venous blood circuit; a blood purifier between the arterial blood circuit and the venous blood circuit that purifies the blood flowing through the blood circuit having a blood flow route through which the blood extracorporeally circulating through the blood circuit flows and a dialysate flow route through which dialysate flows, the blood flow route and the dialysate flow route being separated from each other by a blood purification membrane for purifying the blood; an ultrafiltration unit that performs ultrafiltration by filtering out water from the blood in the blood flow route through the blood purification membrane and draining the water through the dialysate flow route; and a substitution-fluid supply unit that supplies substitution fluid into the blood circuit. The blood purification apparatus includes a plasma-flow-rate-acquiring unit that acquires a plasma flow rate or a correlation value of plasma flow rate with reference to a blood concentration detected from the patient's blood and a plasma total protein detected from the blood flowing through the blood circuit.

The disclosure relates to devices and methods for extracorporeal conditioning of blood. Extracorporeal blood oxygenators and blood oxygenator components, such as conditioning modules, are described. An extracorporeal blood oxygenator includes a conditioning module having an external frame, an inlet cover, an outlet cover, and an internal chamber. A fiber assembly is disposed within the internal chamber and a potting material on the fiber assembly creates a circumferential seal that defines a passageway through the fiber assembly having a substantially circular cross-sectional shape. A fluid inlet is in fluid communication with the passageway, has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly, and has an internal curvilinear surface adjacent the fiber assembly. A fluid outlet on the opposite side of the fiber assembly also has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly.

A removable pressure sensor assembly senses a pressure in an elastically deformable tube conveying blood in an extracorporeal circulator. The assembly includes a main body portion 31 and a pressure measurement element 40 disposed in main body portion 31. Main body portion 31 has a base portion 32 with a tube mounting recessed portion 34 such that an intermediate part of a tube 11 is removably fitted such that tube 11 is elastically deformed. Pressure measurement element 40 is exposed to tube 11 so that it measures a pressure of blood inside tube 11. A lid portion 33 holds tube 11 inside tube mounting recessed portion 34 by selectably closing recessed portion 34 of the base portion. Tube mounting recessed portion 34 has a rectangular cross section, and a width L of the rectangular cross section is set to be smaller than an external dimension D of tube 11.

An apparatus for extracorporeal blood treatment, comprising a treatment unit (2) having a first chamber (3) and a second chamber (4) separated from one another by a semipermeable membrane (5), a blood removal line (6) connected in inlet with the first chamber (3) and a blood return line (7) connected in outlet with the first chamber; an infusion line (9;9a, 9b) of a replacement fluid and a fluid evacuation line (10) connected in outlet from the second chamber. A regulating device (20) of a transmembrane pressure is active on at least one of the lines and a control unit (15) is configured to: command the regulating device (20) by setting a first increase (TMP.sub.1), determine a value of a control parameter (.sub.1) corresponding to the first increase, compare the value of the control parameter (.sub.1) with a reference value (.sub.ref) and, if the value of the control parameter is greater than the reference value, command the regulating device (20) by setting a second increase (TMP.sub.2) which is greater than the first increase (TMP.sub.1).