A blood component collection cassette, kit, or system, and a flow path internal pressure detection method capable of accurately measuring a circuit internal pressure. A flow path formed in a cassette body has a first line through which blood flows when a blood component separation device is in operation, and a second line through which blood does not flow when the blood component separation device is in operation. The first line has a first pressure-receiving portion pressed by a first load detector. The second line has a second pressure-receiving portion pressed by a second load detector.

The disclosure provides a method of placing a cardiac drainage cannula into a patient's heart. In some embodiments, the method comprises the steps of (a) inserting the cannula percutaneously into an internal jugular vein, (b) advancing the cannula through the internal jugular vein and into the right atrium of the heart, and (c) advancing the cannula through the atrial septum into the left atrium of the heart. Further aspects of the disclosure provide a method of draining blood from the left atrium or left ventricle of a patient's heart using a cardiac drainage cannula. The disclosure also provides a cardiac drainage cannula and a mechanical circulatory support system.

A blood pressure prediction method and an electronic device using the same are provided. The method includes the following steps. A training data set is collected. A first blood pressure prediction model is established according to the training data set. Hemodialysis parameter data of a target patient is received, wherein the hemodialysis parameter data includes a first hemodialysis parameter at a previous time point and a second hemodialysis parameter at a current time point. A hemodialysis parameter variation amount between the first hemodialysis parameter and the second hemodialysis parameter is calculated. The hemodialysis parameter variation amount is provided to the first blood pressure prediction model to generate a prediction blood pressure variation associated with a next time point. An operation is performed according to the prediction blood pressure variation of the target patient.

A signal filtering device implements a filtering method that involves operating a digital filter (60) on a pressure signal (p), which represents fluid pressure in a medical apparatus, to produce a filtered signal (y). The method further comprises detecting or predicting presence of a disturbance in the pressure signal (p), and selectively modifying a state vector of the digital filter (60) at a selected time point subsequent to the disturbance in the pressure signal (p), so as to suppress influence of the disturbance on the filtered signal (y). The state vector may be modified by replacing the state vector of the digital filter (60) at the selected time point (t.sub.2) by a dedicated reconfiguration state vector (Z).

A tubular medical fluid flow set comprises a pressure sensing chamber connected in flow-through relation to fluid flow tubing of the set. The pressure sensing chamber defines a movable, flexible, impermeable diaphragm dividing the chamber into two separate compartments. The fluid flow tubing communicates with one of the compartments and is isolated from the other of the compartments. A port is carried on the chamber, the port having a seal therein, and communicating with the other of the compartments. Thus, the other of the compartments is hermetically sealed until the port is opened for connection with a pressure measuring device, to keep the flexible diaphragm in a desired, initial position prior to opening of the seal.

A method of identifying a type of a filter, which has at least one retentate side and at least one permeate side separated from one another by at least one filter medium, includes generating a pressure in a fluid, in particular in a liquid, on the retentate side or on the permeate side via a pressure source. The method then includes switching off the pressure source, and measuring a pressure development in the fluid over time subsequent to the switching off of the pressure source.

The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The manifold includes diaphragms adapted to minimize the dead space between the dialysis machine pins and improve responsivity. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface and a heater in thermal communication with the container. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features.

A cassette holder includes an actuator assembly and a cassette plate. The actuator assembly includes an actuator (e.g., a valve actuator or a sensing actuator) and a shaft, with the shaft including a head, a base, and a perimeter groove defined between the head and the base. The cassette plate includes an opening aligned with the actuator and a keyhole at least partially aligned with the shaft. The keyhole is associated with a channel of the cassette plate, which is configured to receive at least a portion of a lever. The lever is movable between a locked position (in which the lever is primarily positioned within the channel) preventing removal of the shaft from the keyhole and an unlocked position (in which the lever is primarily positioned outside of the channel) allowing for removal of the shaft from the keyhole.

The disclosure relates to devices and methods for extracorporeal conditioning of blood. Extracorporeal blood oxygenators and blood oxygenator components, such as conditioning modules, are described. An extracorporeal blood oxygenator includes a conditioning module having an external frame, an inlet cover, an outlet cover, and an internal chamber. A fiber assembly is disposed within the internal chamber and a potting material on the fiber assembly creates a circumferential seal that defines a passageway through the fiber assembly having a substantially circular cross-sectional shape. A fluid inlet is in fluid communication with the passageway, has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly, and has an internal curvilinear surface adjacent the fiber assembly. A fluid outlet on the opposite side of the fiber assembly also has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly.

A blood treatment system with pressure sensors may be configured to control blood flow to and from the patient and use readings of the pressure sensors to determine a change in a pressure drop across a flow restriction in the blood circuit to estimate a condition of the machine or the patient, or outputting data responsive to the estimation. Further embodiments employ measurement of pressure drop to detect abnormal viscosity or viscosity variations in order to detect possible infection.