Provided is a priming method including a step of filling a priming liquid in a hollow-fiber membrane module in which hollow-fiber membranes are packed in a vessel having an inlet port, an outlet port, and a filtrate discharge port at a linear velocity of 20 cm/min or more and 550 cm/min or less through the inlet port or the outlet port in an amount of 15% or more relative to a volume of the hollow-fiber membrane module. According to the present invention, the effective filtration area at the time of cell suspension treatment is increased, and the recovery rate of cells and the filtration rate can be improved. Further, since the cell treatment can be completed while maintaining the closed environment, the obtained cells can be provided for therapeutic applications.

A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.

The present disclosure concerns a method for preparing an extracorporeal blood circuit for its use in a blood treatment of a patient, which treatment is carried out using a blood treatment apparatus and using a blood treatment device, which comprises a blood chamber and a dialysate chamber partitioned off therefrom by a membrane, The method comprising: filling the extracorporeal blood circuit using a priming solution, wherein the priming solution comprises citrate, or filling of the extracorporeal blood circuit using a priming solution and using a citrate solution. The invention further comprises devices suitable for carrying out the method.

A blood purification apparatus and a blood purification system that is operable with increased ease even if a blood purifier requires special treatment conditions and operational settings is used. A blood purification apparatus includes a blood purifier for giving blood purification treatment by purifying blood of a patient; and a control device that executes, in accordance with preset treatment conditions and/or operational settings, an operation for performing the blood purification treatment or an operation associated with the blood purification treatment. The blood purification apparatus includes a registering device that is capable of registering, in advance, the treatment conditions and/or operational settings corresponding to a performance, characteristic, or function of the blood purifier; and a changing device that is capable of changing the treatment conditions and/or operational settings to the treatment conditions and/or operational settings registered by the registering device, in accordance with the blood purifier to be used in the blood purification treatment.

A method of removing blood from an extracorporeal blood circuit and/or a functional device, each of which is connectable or connected with a blood treatment apparatus for the purpose of a blood treatment of a patient, after concluding a blood treatment session, the method comprising operating a blood pump in a second conveying direction which is opposite to a first conveying direction of the blood pump which is customary during the blood treatment, and an arterial line section of the extracorporeal blood circuit is or will be connected with a venous line section of the extracorporeal blood circuit.

Flow rate of a blood delivery pump of a blood treatment apparatus is determined and adjusted by connecting a fluid filled container with an extracorporeal blood line of the blood treatment apparatus, performing a priming step to prime the extracorporeal blood line by driving the blood delivery pump at a predetermined theoretical delivery rate to deliver fluid from the filled container into the extracorporeal blood line, determining the loss of fluid of the fluid filled container due to delivery of fluid into the extracorporeal blood line during priming, and determining a correction factor by comparison of a value for an amount of fluid delivered under the theoretical delivery rate with a value for the amount of fluid actually delivered.

A blood purification apparatus includes a blood circuit through which blood of a patient extracorporeally circulate, and a dialyzer that purifies the blood flowing in the blood circuit. The apparatus includes a pressure-change-producing device capable of applying a positive pressure or a negative pressure to distal portions of the blood circuit while an arterial puncture needle (a) and a venous puncture needle (b) are yet to be connected to the blood circuit, a pressure-change-detecting device capable of detecting pressure changes in the distal portions of the blood circuit that occur when the distal portions of the blood circuit that are under the positive pressure or the negative pressure applied by the pressure-change-producing device are connected to the arterial puncture needle (a) and the venous puncture needle (b) that are stuck in the patient, and an evaluation device capable of evaluating a state of sticking of the arterial puncture needle (a) and the venous puncture needle (b) on the basis of the pressure changes detected by the pressure-change-detecting device.

The invention relates to a container in the form of a bag having a flexible bag wall at least in a region, in which a first and a second hollow channel section, pass through the bag wall in a fluid-tight manner, wherein the hollow channel sections respectively have an open channel end that is located within the container for connecting the open channel ends to one another in a separable and fluid-tight manner.

Hemodialysis systems are described. A hemodialysis system may include a dialysate flow path through which dialysate is passed from a dialysate reservoir, which includes a valved vent to atmosphere, to an ultrafilter. The dialysate flow path includes a pneumatically actuated diaphragm-based dialysate pump for pumping fluid from the dialysate reservoir to the ultrafilter. The hemodialysis system may include a controller for controlling pneumatic actuation pressure delivered to the dialysate pump and at least one valve connecting the dialysate reservoir vent to the atmosphere. The hemodialysis system may be configured to actuate the dialysate pump and the at least one valve to introduce air into the dialysate flow path and expel liquid from the dialysate flow path to a drain.

A blood component separation device for separating a plurality of blood components from blood sampled from a blood donor, and collecting platelets, includes: an operation unit that calculates a predicted platelet recovery rate from a hematocrit value of the blood and a platelet concentration of the blood, and calculates a recommended processing amount of the blood recommended for collecting a target number of units of platelets on the basis of the calculated predicted platelet recovery rate, wherein the operating unit sets the predicted platelet recovery rate calculated from any the hematocrit value and any the platelet concentration to be smaller by a predetermined value a when the blood donor is female than that when the blood donor is male.