This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

A device for establishing venous inflow to a blood reservoir of an extracorporeal blood circulation system includes a restricting unit for gradually closing a venous inflow line and a vacuum unit for supplying vacuum to the blood reservoir. The device includes a control unit that supplies a first actuating signal to the restricting unit for restricting venous inflow to the blood reservoir and supplies a second actuating signal to the vacuum unit for establishing a degree of vacuum within the blood reservoir.

An apparatus for shunting blood includes a flow-indication chamber shaped to define an entry port and an exit port, and one or more moveable objects disposed within the flow-indication chamber and configured to move in response to a flowing of the blood from the entry port to the exit port. At least a portion of a wall of the flow-indication chamber is transparent so as to expose the moveable objects to sight. Other embodiments are also described.

A blood treatment device includes an extracorporeal blood circuit, a dialyzer and a dialysis fluid circuit. The extracorporeal blood circuit and the dialysis fluid circuit are separated from each other by a membrane provided in the dialyzer, by which blood can be filtered. At least one substitution solution pump supplies a substitution solution to the extracorporeal blood circuit before and/or after the dialyzer. A control unit calculates a difference or a backlog between an ideal target volume and an actually controlled volume of the supplied substitution solution, and temporarily increases a controlled flow rate of the substitution solution pump under corresponding controlling thereof by a predetermined, fixed percentage which is less than or equal to 5%, until the difference or the backlog between the actually controlled volume and the ideal target volume no longer exists, i.e. the actually controlled volume corresponds to the ideal target volume.

Methods, systems, and devices are disclosed, embodiments of which provide single pass dialysis to remove water and uremic toxins is performed simultaneously with the albumin dialysis therapy by passing the albumin solution through a dialysis filter which dialyses it before the solution is returned to the cycler. In embodiments, the single pass dialysis stage is upstream of the albumin filtering stage.

A fluid flow sensing and bubble detecting apparatus includes a housing comprising a channel configured to receive a tube through which fluid flows; a sensor apparatus disposed within the housing, which includes a first sensor operable to measure flow rate of fluid and to detect bubbles in flowing fluid; and a temperature sensor operable to detect temperature of the flowing fluid; and a processor connected to receive fluid flow rate data obtained by the first sensor, to receive bubble detection data obtained by the first sensor, and to receive fluid temperature data obtained by the temperature sensor, wherein when a tube through which fluid flows is disposed in the channel of the housing, the first sensor measures the flow rate of the flowing fluid and detects bubbles therein, and the temperature sensor measures the temperature of the flowing fluid, and the processor calculates in a short period of time a fluid flow rate corrected for temperature. All sensors are non-invasive and have no direct contact to the fluid in the tube, which might be blood. In accordance with additional embodiments, the fluid flow rate is additionally corrected for hemoglobin or hematocrit, and the effect of oxygen saturation on the hemoglobin or hematocrit data.

A portable device for monitoring vascular access status is disclosed. The portable device comprises a measurement device and a monitoring module. The measurement device senses vibration data induced by blood flow over certain part of a vascular access of a subject via a vibration-sensing module, and sends the sensed data to outside via its communication module. The monitor module controls an electronic device to receive the sensed data and determines a vibration evaluation index corresponding to a status of the part of the vascular access. The portable device for monitoring vascular access status of the present disclosed example has advantages of small size, easy to carry, low cost, and so on, so as to be applicable to home vascular access status monitor.

To provide a prediction display system and the like that utilize information obtained before an operation and during the operation, and predict an onset risk of a postoperative complication such as an acute kidney injury which has become a particularly great clinical problem. A prediction display system is configured such that an onset risk of a complication occurring after an operation is predicted using at least one of pH (hydrogen ion exponent), pO2 (oxygen partial pressure), Ht (hematocrit value), Hb (hemoglobin), DO2 (transportation amount of oxygen), and pCO2 (arterial blood carbon dioxide partial pressure) as parameters of blood gas taken before the operation and during the operation, and the onset risk of the complication occurring after the operation is displayed.

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.