Embodiments of the present disclosure include a dialysis system having a disposable cartridge which includes one or more flowpaths arranged on or within the cartridge, where the one or more flowpaths including at least one of a blood flowpath for carrying a volume of blood to be treated in a dialyser and a dialysate flowpath, isolated from the blood flowpath, for delivering a flow of dialysate solution through the dialyser.

An apparatus for extracorporeal treatment of blood including a filtration unit, a blood withdrawal line, a blood return line, an effluent fluid line, a dilution fluid line connected to the blood withdrawal line, and a dialysis fluid line. Pumps act on the fluid lines for regulating the flow of fluid. A control unit sets initial values for a fluid flow rate(s) through the lines and periodically executes a flow rate update procedure to adjust the fluid flow rate(s) to deliver a set dose (Dset) in a reference time interval.

The invention relates to a device for extracorporeal blood treatment, comprising a blood treatment unit 1 that comprises at least one compartment 4. The invention further relates to a method for determining a hemodynamic parameter during an extracorporeal blood treatment by means of an extracorporeal blood treatment device. In order to determine the hemodynamic parameter, the conveying direction of the blood pump 10 is reversed from a normal blood flow to a reversed blood flow. In practice, it has been found that reversing the conveying direction of the blood pump for a measurement for determining a hemodynamic parameter carries the risk of blood clots reaching the patient, despite the dialyser holding back blood clots. The blood treatment device comprises an input unit 23 for inputting a time interval which can be specified by the user, taking into account the patient-specific and system-specific factors. The control and evaluation unit 12 of the blood treatment device is configured such that the operation of the blood pump 10 in the operating mode involving a reversed blood flow is only enabled during the time interval input by means of the input unit, the start of the time interval being determined from the point at which the blood treatment starts.

Embodiments of the disclosure provide a method for evaluating dialyzers used in different medical applications (e.g., hemodialysis). Red blood cell volume lost in a dialyzer is monitored by obtaining blood flowrate measurements and hematocrit measurements at input ports and output ports of the dialyzer. The flowrate and hematocrit measurements are used to determine an accumulation of red cell blood volume in the dialyzer. The measurements may be obtained in a lab environment with an in-vitro blood source or may be obtained in a clinical setting with an in-vivo blood source from a patient.

An apparatus for performing haemodialysis on a patient comprises: first blood transfer means (3) for selectively withdrawing blood from a patient and storing it in a first storage portion (5); second blood transfer means (11) for removing filtered blood from a filtration device (7) and storing it in a second storage portion (13); and a fluid measurement system (51a, 51b) for periodically measuring the respective volumes of blood in the first and second storage portions; adding the volume of blood in the first storage portion to the volume of blood in the second storage portion at that time in order to calculate the total volume of blood within the first and second storage portions at that time; and comparing the total measured volumes of blood within the first and second storage portions measured over a predetermined time interval to calculate the volume of fluid removed from the blood during that predetermined time interval.

Provided is a calibration method for flowmeters in a blood dialysis system, whereby highly accurate calibration can be performed even by omitting a reference flowmeter not directly relating to dialysis therapy. This calibration method comprises: while preventing outflow into a blood channel in a blood purifier, supplying a liquid to a channel, said channel passing through an inflow flowmeter and an outflow flowmeter; and then calibrating the inflow flowmeter and the outflow flowmeter correction whereby, at the time of liquid supply, a value measured by the outflow flowmeter is equalized to a value measured by inflow flowmeter.

According to some embodiments, a system may treat blood containing metformin outside the body of a patient. The system may include one or more pumps configured to pump blood in a fluid flow path at a collective rate over 4 liters per minute. The system may include one or more heat exchangers operable to heat at least a portion of the blood to a temperature of at least 42 degrees. The system may include one or more convection dialysis modules configured to perform convection dialysis on at least a portion of the blood at least after the one or more heat exchangers allow the blood to cool one or more degrees.

A fluid flow sensing and bubble detecting apparatus includes a housing comprising a channel configured to receive a tube through which fluid flows; a sensor apparatus disposed within the housing, which includes a first sensor operable to measure flow rate of fluid and to detect bubbles in flowing fluid; and a temperature sensor operable to detect temperature of the flowing fluid; and a processor connected to receive fluid flow rate data obtained by the first sensor, to receive bubble detection data obtained by the first sensor, and to receive fluid temperature data obtained by the temperature sensor, wherein when a tube through which fluid flows is disposed in the channel of the housing, the first sensor measures the flow rate of the flowing fluid and detects bubbles therein, and the temperature sensor measures the temperature of the flowing fluid, and the processor calculates in a short period of time a fluid flow rate corrected for temperature. All sensors are non-invasive and have no direct contact to the fluid in the tube, which might be blood. In accordance with additional embodiments, the fluid flow rate is additionally corrected for hemoglobin or hematocrit, and the effect of oxygen saturation on the hemoglobin or hematocrit data.

A graft with adjustable stenosis having a length of tube having tube wall with a central passage between an inlet end and an outlet end. A flexible barrier is located in the length of tube, that, in a default position, forms a narrowed section in the central passage and establishes a stenosis fluid chamber between the tube wall and the flexible barrier. An aspiration port system includes a port reservoir, containing fluid, and a needle entry seal, for needle access to the port reservoir to remove or add fluid. A channel is in fluid communication with the stenosis fluid chamber, the stenosis fluid chamber containing stenosis fluid chamber fluid. A separator is between the channel and the port reservoir. The flexible barrier is biased to a default narrow position. Responsive to fluid being removed from the port reservoir, the flexible barrier moves to increase the diameter of the narrowed section.

The invention relates to an apparatus for extracorporeal blood treatment, comprising a blood treatment unit 1 that comprises at least one compartment 3. The invention further relates to an apparatus 15A, 15B for collecting blood clots for a blood line 5, 7 for supplying blood to or removing blood from a blood treatment unit 1 of an extracorporeal blood treatment apparatus, and to a method for determining a hemodynamic parameter during extracorporeal blood treatment using an extracorporeal blood treatment apparatus. In order to determine the hemodynamic parameter, the conveying direction of the blood pump 10 is reversed from a normal blood flow to a reversed blood flow. It has been found in practice that, in the event of a reversal in the conveying direction of the blood pump in order to carry out a measurement for determining a hemodynamic parameter, there is a risk of blood clots reaching the patients, although the dialyser traps blood clots. The apparatus according to the invention provides an apparatus 15A for catching blood clots, at least in the blood line of the extracorporeal blood circuit I that leads to the blood treatment unit 1 during a normal blood flow. The blood treatment unit traps blood clots during blood treatment having a normal blood flow. In the case of a reversed blood flow, the apparatus for catching blood clots in the blood line that leads to the blood treatment unit 1 during a normal blood flow traps blood clots that may have previously accumulated at the inlet of the blood treatment unit.