The present invention is directed generally to a method and apparatus for human brain neuroprotection during surgery. The invention includes use of a heart-lung machine to generate periodic rectangular pulsation of blood flow. The invention uses a non-invasive CA monitor to continuously record transient functions such as dynamic autoregulation functions of a human brain cerebrovascular autoregulation system and process the data to generate an alarm to indicate CA impairment and take steps to minimize the CA impairment event.

The present disclosure describes intravascular oxygenation systems and methods with one or more of improved oxygen diffusion flux, improved resistance to bubble formation on the surface of non-porous hollow fibers, and reduced size. The systems and methods include a pneumatic inlet coupled to a pneumatic source that provides a gas containing oxygen at a high pressure. A plurality of hollow fiber membranes (HFM) are in pneumatic communication with the pneumatic inlet to receive the gas containing oxygen and with an outlet to exhaust a partially deoxygenated gas. An electronic controller drives the motor to oscillate the plurality of HFMs to cause a diffusive flux of the gas containing oxygen from the plurality of HFMs into a region of interest of a subject. The electronic controller may drive the motor according to an oscillation pattern, which may include a macro-oscillation with superimposed micro-oscillations.

System and method for bi-directional fluid injection includes a retrograde introducer, a retrograde cannula having an inlet opening, intermediate opening and outlet opening, an antegrade introducer and an antegrade cannula. The retrograde introducer is configured to engage with the retrograde cannula and to insert the retrograde cannula into a fluid channel. The antegrade introducer is configured to engage with the antegrade cannula and to insert the antegrade cannula into the fluid channel from within the retrograde cannula through the intermediate opening. After insertion of both cannulas, both introducers are removed. In operation, fluid flows into the retrograde cannula inlet and a portion thereof is diverted to the antegrade cannula which flows the portion in a first direction in the channel, the remainder of the fluid flows out the retrograde cannula outlet in an opposite direction in the channel. The system is removed from the channel using the introducers in reverse order.

The present disclosure relates to a system for temperature management for patients in stationary and mobile ECLS and/or ECMO therapy, with a disposable and a fluid circuit, wherein the disposable comprises a reservoir or bag provided with at least one supply line and a drain line, further comprising a pumping unit element as part of the disposable, by means of which liquid in the reservoir or bag can be pumped through the fluid circuit, wherein in the mounted state of the system all fluid-guiding parts of the system are completely encapsulated and separated from intracorporeal and extracorporeal blood circuit of the patient undergoing the ECLS and/or ECMO therapy.

A venous drainage cannula, catheter, or other device is in certain embodiments convertible or adjustable for application in cardiac surgery procedures involving cardiopulmonary bypass. Such a convertible cannula device can be modified, for example, for use as both a multi-stage cannula and a bi-caval cannula, so that the same device can be used in multiple different procedures where one or the other cannula type is needed. Such convertible cannula or other device can simplify and reduce a number of parts needed for a bypass procedure, by providing one adjustable and versatile device to serve multiple functions where different cannulae are traditionally required. Various embodiments further provide cannula devices where a variety of different hole or opening arrangements and configurations can be achieved, to adapt to various different procedures.

The present disclosure pertains to control units for non-occlusive blood pumps of an extracorporeal circulatory support as well as systems comprising such a control unit and corresponding methods. Accordingly, a control unit for a non-occlusive blood pump of an extracorporeal circulatory support is configured to receive a flow value of the extracorporeal circulatory support, to receive a measurement of an arterial pressure and an ECG signal of a supported patient over a predetermined period of time, to determine a mean arterial pressure of the extracorporeal circulatory support or of the supported patient from the measurement of the arterial pressure and an energy equivalent pressure from the flow value and the arterial pressure.

The present invention relates to a system for the selective treatment of one or more organs, said system comprising a first catheter comprising a means for occluding a first lumen downstream of said organ(s); a second catheter comprise a means for occluding a second lumen upstream of said organ(s); an extracorporeal device configured to deliver fluid through the first catheter and to receive fluid through the second catheter, and comprising means for processing the fluid. The present invention also relates to a method for the selective treatment of one or more organs.

Devices, systems and methods for cardiac and vascular access configured to allow for intracardiac access to conduct medical procedures. The devices, systems and methods are particularly useful in trans-cardiac extra-corporeal membrane oxygenation (ECMO) procedures, ventricular assist procedures, cardiopulmonary bypass, or other medical procedures where intracardiac access may be required.

An oxygenation system for a ventilation system comprises an inlet for receiving oxygenation gas at an oxygenation gas flow rate into an oxygenator, and an exhaust gas remover to remove exhaust gas at an exhaust gas flow rate from the oxygenator, and one or more flow controllers for controlling the exhaust gas flow rate relative to the oxygenation gas flow rate. This allows the amount of total gas entering the oxygenator and the amount of total gas removed from the oxygenator to be controlled with greater accuracy.

A control system controlling blood gas values in blood processed by an oxygenator, wherein the oxygenator generates arterial blood by exposing venous blood to oxygen from an oxygenation gas supply, comprises a monitoring arrangement to determine a level of the blood gas values in the arterial blood and a controller that is responsive to the monitoring arrangement and configured to control parameters of the oxygenation gas supply to the oxygenator. This allows the blood gas values to be adjusted toward a pre-determined level.