Provided are a connection structure and a blood purifying device which are capable of enhancing the durability of seal members. This connection structure 1 is roughly configured to be provided with: a connection part 3 attached to a main body 90 which has a housing 20, a diaphragm 25, a chamber 2, and a coupling 30 for connecting an output port 27, and which has a pressure sensor 10a for detecting a pressure PK of a gas K output from the coupling 30; and a seal member which is sandwiched by the lateral surface 270 of the output port 27 and the lateral surface 302 of the coupling 30, and which moves while changing the seal position when connecting or disconnecting the chamber 2 and the connection part 3.

Various embodiments disclosed relate to a system and methods for hemodialysis, including detachable sorbent cartridge canisters. The present disclosure can include a system for hemodialysis having a first dialysis module including a dialyzer, a blood circuit configured to receive blood from a patient, circulate the blood through the dialyzer, and return cleaned blood to the patient, a dialysate circuit configured to circulate dialysate through the dialyzer and remove impurities from the blood, and a first canister detachably coupled to dialysate circuit, the canister comprising a first sorbent.

A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

A patient's body temperature measurement may be made by varying the heat transfer dynamics of a fluid exiting the patient's body and fitting parameters of heat transfer configuration to measurements under the varied conditions. Then the input temperature of the patient core can be extracted from the model and a current temperature measurement remote from the patient core and optionally other measurements such as fluid flow rate.

The present invention relates to a method for checking the conveying accuracy of conveying devices of a blood treatment apparatus. It further relates to a blood treatment apparatus with a control device and/or closed-loop control device, through which the method is effected, a digital storage medium, a computer program product, and a computer program.

The invention relates to an arrangement having a blood pump and a gas exchanger for extracorporeal membrane oxygenation. According to the invention, the blood pump is designed as a pulsatile blood pump and is arranged with the gas exchanger in the same housing. The pulsatile blood pump and the gas exchanger are preferably connected to the same gas source so that the blood pump can be pneumatically driven. The novel ECMO system has a simple design, is flexible, and in particular can be used directly on the patient.

A tube connector is configured to connect between a main tube and a peristaltically-actuated tube. The tube connector includes a first connection part configured to be connected to the main tube; a second connection part configured to be connected to the peristaltically-actuated tube; a communication part being provided between the first connection part and the second connection part and having a communication flow path for communicating between a first flow path through which fluid flows in the first connection part and a second flow path through which the fluid flows in the second connection part; and a main body section. The first flow path and the second flow path are formed to have a constant diameter and are formed so as to extend along the axial direction of the main body section. A diameter of the first flow path is smaller than a diameter of the second flow path. The communication flow path is formed so as to gradually enlarge in diameter from a first flow path side to a second flow path side. A central axis of the first flow path and a central axis of the second flow path are shifted toward the radial direction of the main body section.

Embodiments of the present invention provide an extra corporeal membrane oxygenation circuit, wherein a pump communicates blood from a patient to an oxygenator and thence back to the patient, comprising: (a) a medium diameter venous line configured to accept blood from the patient and communicate the blood to the pump; (b) a medium diameter arterial line configured to accept blood from the oxygenator and communicate the blood to the patient; (c) one or more shunts connected in a series, where each shunt comprises a medium diameter input connected to a medium diameter output, where the medium diameter output is configured to connect to a medium diameter input of a successive shunt; a small diameter outlet between the medium diameter input and the medium diameter output; and a stopcock connected to the small diameter output such that flow out of the small diameter outlet can be controlled by the stopcock; wherein a first of such shunts is connected to accept blood from the venous line in parallel with the pump and wherein a last of such shunts is connected to communicate blood to the arterial line.

An automatic monitoring system for a medical treatment device helps to ensure that an a medical treatment device operated at a treatment location away from a clinic is preformed safely. The monitoring system may verify that an assistant is present during treatment of the patient. Among the features disclosed biometric authentication to verify that a trained assistant is present, a presence detector to ensure the assistant is continuously present during treatment, and warning and recovery processes that allow intermittent lapses in the continuous presence of the assistant. The treatment device also communicates with a remote server or terminal.

An apparatus for measuring pressure within a fluid path includes a housing defining the structure of the apparatus. The housing includes a fluid path that extends through the housing and allows a fluid to pass through the housing. The apparatus also includes a first volume chamber that is in fluid communication with the fluid path and has a first volume chamber opening, and a second volume chamber with a second volume chamber opening that is less than the first volume chamber opening. A diaphragm separates the first volume chamber from the second volume chamber and fluidly disconnects the second volume chamber from the fluid path. The diaphragm deforms based upon the pressure within the fluid path. The apparatus also includes an interface that is connectable to a pressure sensor, and the second volume chamber is in fluid communication with the interface.