Devices, systems, and methods for medication infusion are described herein. In some embodiments, a system includes a patient access subassembly, a first fluid reservoir, a second fluid reservoir, and an assembly. The assembly can have a first configuration in which the patient access subassembly is in fluid communication with the first fluid reservoir via a first tube, a second configuration in which the first fluid reservoir is in fluid communication with the second fluid reservoir, and a third configuration in which the first fluid reservoir is in fluid communication with the patient access subassembly via a second tube, the first fluid reservoir fluidically isolated from the first tube in the third configuration.

An apparatus for shunting blood includes a flow-indication chamber shaped to define an entry port and an exit port, and one or more moveable objects disposed within the flow-indication chamber and configured to move in response to a flowing of the blood from the entry port to the exit port. At least a portion of a wall of the flow-indication chamber is transparent so as to expose the moveable objects to sight. Other embodiments are also described.

A fluid conduit includes a first portion having a first porosity, a second portion disposed immediately adjacent to the first portion, the second portion having a second porosity that is greater than the first porosity, and a third portion of the fluid conduit disposed immediately adjacent to the second portion, the third portion having a third porosity that is less than the second porosity. Each of the first portion, the second portion, and the third portion may be integrally formed as a single, continuous piece defining the fluid conduit.

A syringe pump to deliver heparin to into the blood circuit of a hemodialysis system. The syringe pump is configured to receive a syringe having a plunger movable within a lumen of an elongate tubular member. The syringe pump may include a housing having a recess configured to receive at least a portion of the syringe, a drive mechanism for moving the plunger within the lumen, the drive mechanism comprising a motor and a lead screw; and a grabber mechanism. The grabber mechanism includes a control arm, back panel, and upper and lower control fingers, the control fingers each have first and second ends, and a curved portion therebetween having a width, an interior edge, and an exterior edge, wherein the first ends of the upper and lower control fingers are coupled to the control arm via first and second spring hinges.

A method and device are provided for centrifugally separating plasma from whole blood in which whole blood is introduced into a flow circuit having a blood access device connected to a first tubing for drawing whole blood from a blood source and for flowing whole blood to a centrifugal separation chamber; a volume of saline is added to the whole blood as it flows through the first tubing to dilute the whole blood; the volume of saline added to the whole blood is tracked; the whole blood having the volume of saline added thereto is separated in the centrifugal separation chamber so that an interface is created between the plasma and added saline and the cellular components of the whole blood; the separated plasma and added saline is flowed from the centrifugal separation chamber to a collection container; and a volume for the plasma and added saline in the collection container is determined. The device includes a programmable controller configured operate a first pump to flow saline from the container of saline through the second tubing segment to the first tubing segment, track a volume of saline flowed from the container of saline through the second tubing segment to the first tubing segment, flow separated plasma and added saline from the separation chamber through the third tubing segment to the collection container, and determine a volume for the plasma and added saline in the collection container.

The present disclosure provides extracorporeal membrane oxygenation (ECMO) apparatuses treated to comprise lubricating liquid surfaces, hydrophobic or omniphobic surfaces, and/or fluid and solid repellant slippery surfaces that do not stimulate clotting and thrombus formation to the same degree as do the untreated surfaces. The apparatuses permit ECMO procedures to be conducted using less anticoagulant and/or antiplatelet medications than is possible with untreated apparatuses. Also described are methods of using the treated apparatuses to accomplish ECMO procedures on subjects (e.g., human patients) and upon perfused organs.

An intermediate element for a medical extracorporeal fluid line designed to conduct a fluid, such as blood, has a main part extending between two connection parts. A flow channel passes continuously through the main part and the connection parts. The connection parts hydraulically connect the main body to a fluid line. On the periphery of the main part a receiving area is arranged, which is designed to receive a measurement value transmitter. An opening to the flow channel is defined in the receiving area and is sealed in a fluid-tight manner towards the receiving area by an elastic element. The measurement value transmitter is a gas sensor of a sensor device for measuring at least one gas contained in the fluid. The elastic element is a diffusion element, which is permeable to at least one gas. The diffusion element is bonded to an edge of the opening.

Hollow fiber membranes in an oxygenator for an extracorporeal blood circulator are coated with an antithrombotic polymeric material. The porous hollow fiber membranes for gas exchange have outer surfaces, inner surfaces forming lumens, opening portions through which the outer surfaces communicate with the inner surfaces in a housing. A blood flow path is outside of the hollow fiber membrane bundle in the housing, between a blood inlet port and a blood outlet port. The coating is obtained by filling the blood flow path with a colloidal solution containing an antithrombotic polymeric compound, and moving the colloid solution between the blood inlet port and the blood outlet port for a time that coats a predetermined amount of antithrombotic polymeric compound on the outer surfaces of the hollow fiber membranes. Other surfaces within the oxygenator contacting the blood flow likewise receive the coating.

A medical instrument includes a first tube body and a second tube body joined to the first tube body by being inserted in the lumen of the first tube body. The second tube body is more rigid than the first tube body. The medical instrument includes a coating layer made of a biocompatible material disposed on the inner peripheral surfaces of the first and second tube bodies. The inner peripheral surface of the second tube body is radially inward of the inner peripheral surface of the first tube body to create a level difference portion. The thickness of the part of the coating layer which coats the level difference portion is larger than the thickness of the level difference portion.

Disclosed are methods, systems, and devices for removing cytokines and other substances from blood of a subject in a closed fluid circuit. The methods, systems, and devices involve: (i) passing venous blood from the subject through a plasma separator, thereby separating the blood into blood cells and plasma; (ii) passing the plasma received from the plasma separator through an adsorption chamber located in the circuit to form processed plasma, where materials in the adsorption chamber adsorb cytokines in the plasma to form the processed plasma, and where the materials include, by weight, 50-70% activated carbon and 30-50% non-ionic resin; (iii) combining the processed plasma, received directly from the adsorption chamber, with the blood cells in a combining chamber to form processed blood, without exchanging any of the plasma for another fluid; and (iv) transfusing the processed blood from the circuit directly into the subject, where no fluid besides the subject's blood is added to the circuit before the transfusing of the processed blood into the subject is completed.