Provided is an extracorporeal filtration and detoxification system and method generally including separating ultrafiltrate from cellular components of blood, treating the ultrafiltrate independently of the cellular components in a recirculation circuit, recombining treated ultrafiltrate and the cellular components, and returning whole blood to the patient.

The invention relates to methods and systems for removal of pathogens from blood or blood products. The invention further relates to methods and systems for treatment and diagnosis of infection in the blood and/or sepsis in a patient in need thereof.

A device for regional anticoagulation by citrate-Calcium, of the type usable in a circuit which comprises a first duct or blood line (2) provided with an inlet (1) to withdraw blood from the patient and a downstream outlet (7) for return the treated blood to the patient, device characterized in that it is arranged on said blood line (2) and is provided with a membrane made of a material adapted to bind with the Citrate.

Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.

The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions within a subject and to related methods. More particularly, the invention relates to a cytopheretic cartridge that includes a housing and, disposed within the housing, a solid support capable of sequestering activated leukocytes and/or platelets.

A fully-automatic regional citrate anticoagulation machine is disclosed. A sampling portion extracts a blood sample on line and in real time and sends it to a storage purifier for storage and purification. A sample injection portion conveys the blood sample in the blood sample storage purifier to a sample loading slot through a sample injection tube. An assay and analysis portion conveys, through a sample suction tube, the blood sample to an analyzer for blood sample assay and analysis. The sampling portion, the sample injection portion, the assay and analysis portion and an administration portion are connected to the program control portion. The program control portion controls, according to an internally-set program, operation of the sampling portion, the sample injection portion and the assay and analysis portion, and sends an instruction to the administration portion according to the data result obtained by the assay and analysis portion.

Disclosed are methods, compositions, and devices for improved delivery of regional citrate anticoagulation during extracorporeal blood treatments. Methods comprise quantification of the clearance of calcium and/or citrate using one or more on-line/in-line sensors, establishing a correlation between the differential conductivity between afferent and efferent dialysate and the clearance of calcium and/or citrate. The methods described herein further include quantifying citrate clearance using glucose as a surrogate.

The invention relates to a blood line (108) comprising an infusion site (145) intended to inject into the line a solution comprising: a first main channel (200) having a first passage section, a second main channel (220) having a second passage section, means for the formation (210) of a turbulence area located downstream from the first main channel, located upstream from the second main channel, these formation means comprising a first fluid passage means (224) defining a reduction (225) in the passage section and whose smallest passage section is smaller than the first passage section and smaller than the second fluid passage section, a secondary channel (230) comprising an inlet (231) for letting in the solution and an outlet (232) in fluid communication with the first main channel or the means for the formation of a turbulence area or the second main channel.

This disclosure relates to a method for temporarily interrupting an extracorporeal treatment of blood of a patient by use of a blood treatment apparatus. The method comprises activating or controlling a control device provided and configured to bring the blood treatment apparatus into a state in which the blood treatment of the patient can be interrupted with the intention to continue the blood treatment. This disclosure further relates to a control device, a blood treatment apparatus, a digital storage means, a computer program product as well as a computer program.

A method for temporarily interrupting an extracorporeal treatment of blood of a patient by use of a blood treatment apparatus includes activating or controlling a control device which is provided and configured to bring the blood treatment apparatus into a state in which the blood treatment session of the patient can be interrupted with the intention to continue the blood treatment session. The present invention further provides a control device, a blood treatment apparatus, a digital storage means, a computer program product as well as a computer program.