Methods and systems for the treatment and post-treatment processing of a mononuclear cell product are disclosed. The methods and systems include and provide for the separation of excess conditioning fluid and unbound treating agent prior to return of said treated mononuclear cell product to a patient.

A method of isolating monocyte populations of cells and inducing apoptosis in these populations without production of pro-inflammatory mediators is disclosed. The method comprises isolating the monocytes and, subjecting them to substrate-adherence and serum deprivation conditions. Apoptotic monocytes as prepared are useful for treating inflammation-associated diseases.

A system and method for the treatment of kidney disease, either acute or chronic, in a mammal is disclosed. The method addresses the needs of a patient exhibiting fibrosis formation associated with levels of Gal-3 above normal. Removal of Gal-3 may make conventional treatments of kidney disease more effective, and help stabilize or improve the condition allowing avoidance of progression to end stage renal disease requiring hemodialysis or transplant. Depending on the condition of the patient, the treatment may help stabilize patients to avoid hemodialysis and allow the patient to wait until a transplant may be made available. A suitable patient is treated through apheresis where the patient's blood is withdrawn and ex vivo is treated to remove at least ten percent of Gal-3 from the withdrawn blood. Higher levels, and frequent repetition, may be needed to stabilize and/or improve kidney function in a patient sufficient for ongoing management.

A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

An irradiation device includes a fluid treatment chamber configured to receive a biological fluid container, the fluid treatment chamber having opposing first and second sides, at least one light source disposed adjacent at least one of the first and second sides of the fluid treatment chamber, and an overflow reservoir in fluid communication with the fluid treatment chamber to receive fluid leaking from the biological fluid container. The device also includes a non-contact sensor disposed adjacent the overflow reservoir and configured to generate a signal according to leaked fluid in the overflow reservoir, an indicator, and a controller coupled to the at least one light source, the non-contact sensor and the indicator, the controller configured to activate the indicator upon receipt of the signal from the sensor and to deactivate the at least one light source subsequent to receipt of the signal from the sensor.

Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.

A device for irradiation of a biological product/substance is provided comprising a base; a tray having a first and second side associated with the base and configured to receive a container holding the biological product/substance to be irradiated; a first array of radiation-emitting bulbs mounted in the device adjacent the first side of the tray; a second array of radiation-emitting bulbs mounted in device adjacent a second side of the tray; a first filter mounted in the device between the tray and the first array of radiation-emitting bulbs for blocking and/or reflecting radiation emitted by the first array of a selected wavelength; and a second filter mounted in the device beneath the second array of radiation-emitting bulbs for blocking and/or reflecting radiation emitted by the second array of the selected wavelength.

Embodiments are described for reducing pathogens in a fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell with a plurality of channels through which a fluid to be pathogen reduced is flowed. The flow cell, and fluid, may be illuminated from more than one direction to pathogen reduce the fluid. In embodiments, the fluid may include a photosensitizer to aid in the pathogen reduction process.

Provided are a device and method for using bilirubin photoisomerization to reduce bilirubin interference with laboratory blood tests for other chemical analytes.

An irradiation device includes a processing container including a first chamber, a second chamber and at least one narrow passage in fluid communication at a first end with the first chamber and at a second end with the second chamber, and a rotatable table on which the processing container is mounted, the table having a first state wherein the first chamber is disposed at a higher elevation than the second chamber, and a second state wherein the second chamber is disposed at a higher elevation than the first chamber. The irradiation device also includes ultraviolet (UV) light source disposed proximate to the narrow passage and configured to irradiate fluid passing through the narrow passage.