Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.

Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.

A machine comprising a load-bearing body intended to receive a circuit for the extracorporeal circulation of a biological liquid, where the circuit comprises at least one bag containing the biological liquid, at least one collection container of the biological liquid to be treated, at least one transit duct of the biological liquid connected to at least the bag and to the collection container; a pumping unit/device/component/etc. of the biological liquid crossing the transit duct; an irradiation unit/device/component/etc. by way of UVA rays of the collection container; and at least one containment box defining a containment volume intended to house the collection container and at least one safety chamber arranged below the containment volume and communicating therewith, to collect any possible spillage of the biological liquid from the collection container where the safety chamber has at least one bottom wall and two side walls at which it is hermetically sealed.

A photodynamic therapy device of this disclosure includes: a light emitting unit (112, 112) including light sources (110) each belonging to any one of groups; a photodetector (120X, 120Y) configured to output an electrical signal corresponding to an amount of light received from the light sources (110); a light emission control unit (160) configured to sequentially cause the light sources (110) to emit light for each group; and a computing unit (151) configured to calculate, based on a distance coefficient related to a distance between the photodetector (120X, 120Y) and the light sources (110) belonging to the each group, and on a value of the electrical signal output by the photodetector (120X, 120Y) in accordance with light emitted from the light sources belonging to the corresponding group, a group light amount value related to a light amount of the light sources belonging to the each group.

Provided are systems and methods for treating a biological fluid, e.g., to inactivate pathogens.

Devices for monitoring cancerous cells in blood of a patient that are preloaded with a marker and a magnetic agent and removing them are provided. The device comprises a tray onto which blood withdrawn from the patient flows before returned to the patient; a magnet placed at a distance from the tray so that the blood on the tray is within a magnetic field of the magnet and the cancerous cells that are preloaded with the magnetic agent are forced to move from the blood on the tray towards the magnet. A detector configured to detect the marker in the cancerous cells in the blood on the tray is provided as well and a filter that is placed between the tray and the magnet so as to capture the cancerous cells that are forced to move towards the magnet and remove them from the blood of the patient.

The photodynamic therapy device of the present disclosure is a photodynamic therapy device that irradiates light from a light source onto blood that has been taken out of a patient's body and is flowing in the blood tube, the blood having absorbed a photoreactive agent, to destroy an undesirable component in the blood or affect the component. The photodynamic therapy device includes the irradiation unit that includes a light source and irradiates the blood in the blood tube with light, and the circuit cooling block that cools the blood in the blood tube. The circuit cooling block is connected to the pump that circulates cooling water in the circuit cooling block, the reservoir tank, and the cooling unit that cools water by the water flow path for flowing the cooling water.

Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.

Disclosed herein is systems, methods, and apparatuses for treating biological fluids. In some embodiments, the biological fluid treatment system includes a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system includes a scanner.

Provided are methods and systems for the pathogen inactivation of blood products and compositions, including methods of using devices (e.g., comprising component(s) configured to control flow of fluid(s)) to determine the amount of pathogen inactivation compound (PIC) necessary for pathogen inactivation of a blood composition (e.g., based at least in part on one or more input parameters) and allow transfer of the blood composition and the PIC into a container, e.g., of a processing set.