Described is a method for controlling fluid volume balance. A controller is configured with a first set of inputs comprising a hematocrit, a total blood volume, and an ACD ratio. A maximum extracorporeal RBC amount during the procedure is estimated based on the first set of inputs. A fluid circuit is primed with a priming fluid. Whole blood is drawn from a blood source and separated into a RBC component, a target cell component, and a plasma component. The target cell component is directed to a product container. The product container comprising the target cell component is treated. A treated target cell component, a portion of the RBC component remaining in the fluid circuit, and/or a portion of the plasma component remaining in the fluid circuit are returned to the blood source. A first response action is provided if the maximum extracorporeal RBC amount estimated is above a programmed limit.

Blood treatment methods that are combined in a unique manner can provide health benefits to patients by performing the methods and using systems that perform such methods. Methods of treatment include withdrawing the blood from a patient, performing multiple blood treatment methods on the blood, and then inserting the treated blood back into the patient. As a result of the treatments, the blood is cleansed and energized, enabling it to perform at higher levels than it would otherwise perform. The treatment methods can include, for example, performing an oxygen-based treatment, such as ozone generation, in combination with mixing methylene blue with the oxygenated blood. In some embodiments, a red light treatment can also be introduced in conjunction with the use of methylene blue. Systems that enable these treatment methods are also provided.

The photodynamic therapy device of the present disclosure is a photodynamic therapy device that irradiates light from a light source onto blood that has been taken out of a patient's body and is flowing in the blood tube, the blood having absorbed a photoreactive agent, to destroy an undesirable component in the blood or affect the component. The photodynamic therapy device includes the irradiation unit that includes a light source and irradiates the blood in the blood tube with light, and the circuit cooling block that cools the blood in the blood tube. The circuit cooling block is connected to the pump that circulates cooling water in the circuit cooling block, the reservoir tank, and the cooling unit that cools water by the water flow path for flowing the cooling water.

Methods and systems for maintaining patient fluid balance during an extracorporeal cell treatment are disclosed. The method includes minimizing the amount of saline or other fluid that is returned to the donor. Saline used during priming of the fluid circuit may be used to increase the volume of the collected cells to arrive at a treatment-ready product with a suitable hematocrit.

Provided is a photodynamic therapy device that enables efficient light irradiation of blood of a patient. A photodynamic therapy device (100) of this disclosure includes a cartridge (10) including a winding core and a tube arranged so as to be wound around the winding core, a casing (50) configured to accommodate the cartridge (10), and a light source (60), which is arranged inside the casing (50), and is configured to irradiate the tube with light. The tube arranged around the winding core has a cross section taken along a direction orthogonal to an extending direction of the tube, which has a first dimension in a first direction and a second dimension in a second direction orthogonal to the first direction. The second dimension is smaller than the first dimension. The second direction is directed outward with respect to the winding core.

A system and a method facilitate the extracorporeal inactivation of pathogens of blood products. The system includes an input peristaltic pump, at least one apheresis device, at least one plasma-treating system, and an output peristaltic pump. The input peristaltic pump, the apheresis device, the plasma-treating system, and the output peristaltic pump are in fluid communication with each other. The plasma-treating system includes at least one primary ultraviolet light (UVL) device, at least one heating device, and at least one cooling device. The input peristaltic pump facilitates the flow of blood from a patient through the system. The apheresis device facilitates separating of plasma from one or more blood cells. The plasma-treating system heats the plasma, inactivates pathogens within the plasma, and then cools the plasma. The output peristaltic pump facilitates the flow of blood from the system and back to the patient.

A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.

Provided are methods for preparing pathogen-inactivated platelet compositions, as well as processing sets and compositions related thereto.

A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

A blood processing apparatus including a blood supply unit, a centrifuge, a light irradiation unit, a filtering device, and a blood collection unit, which is characterized in that blood is introduced into the centrifuge and centrifuged, the centrifuged blood is passed through a transparent tube provided in the light irradiation unit while being irradiated with light applied, from the outside of the transparent tube, by a light irradiation device configured to include an infrared lamp with a wavelength of 830±5 nm, a red light-emitting diode (LED) lamp with a wavelength of 635±6 nm, a blue LED lamp with a wavelength of 420±5 nm, a green LED lamp with a wavelength of 530±5 nm, a yellow LED lamp with a wavelength of 585±5 nm, and ultraviolet (UV) lamps, and the blood irradiated with the light is filtered using the filtering device and collected in the blood collection unit.