A percutaneous transluminal angioplasty (PTA) catheter may be configured to perform vein expansion and occlusion. A infusion port located proximal to the occlusion feature can be used to inject contrast enhancement agent as well as other substances. The catheter can be used especially advantageously in vascular regions associated with hemodialysis access.

A valve is disclosed that has a body with an inlet, an outlet, and a needleless access port coupled to the body. The access port has an interior space and is configured to be actuated by a needleless connector. The inlet is selectively coupled to the outlet through the interior space such that fluid entering the inlet entirely flows through the interior space to the outlet.

Apparatus and methods for providing controlled pressure-flow pulses which purge a catheter system with turbulent flow flushing. Accomplishment of such controlled pressure-flow pulses is provided by a variety of inventive devices including a special plunger rod for a conventional syringe, other interactive parts for conventional syringes, an in-line catheter attachable device which automatically generates the controlled pressure-flow pulses and also single pulse, digitally operated devices.

A drug solution administration apparatus includes an injection unit comprising an injection member configured to inject a drug solution; a delivery unit configured to be coupled to and decoupled from the injection unit, the delivery unit comprising: a delivery member configured to deliver the drug solution to the injection member, and a delivery device configured to deliver the drug solution to the delivery member; a detection unit configured to detect whether the injection unit and the delivery unit are coupled or decoupled; and a control unit configured to control operation of the delivery device. The control unit is configured to perform at least one of (i) restricting the filling operation when the detection unit detects that the injection unit and the delivery unit are coupled, or (ii) restricting the administration operation when the detection unit detects that the injection unit and the delivery unit are decoupled.

Systems and methods are provided for intermittent microinfusion. A system may include a pump and an IV set that includes a y-port valve disposed below a pump interface portion of the IV tubing. The y-port valve may include an internal valve member that allows fluid to flow from the pump to a patient when no syringe is attached to the y-port. The internal valve member may be moved by the attachment of a syringe containing the medication to be infused to the y-port such that the fluid pathway from the pump to the patient is blocked and fluid from the syringe can be injected into the IV tubing between the y-port valve and the pump. The pump may retrograde pump the medication into the tubing via the y-port valve and then forward pump the medication to the patient when the syringe is removed from the y-port.

A therapeutic device for treating an acute medical condition of a patient such as cardiac arrest is provided. The device includes one or more sensors that monitor parameters such as heart rhythm that relate to the patient's medical condition. The device also includes a plurality of medication reservoirs, each reservoir including a conduit, wherein each reservoir holds a predetermined medication that may be used to treat the condition. A manifold is connected with the reservoirs via their respective conduits. A delivery line is connected with the manifold to deliver fluids from the manifold to the patient intravenously. One or more medication pumps are in fluid connection with respective ones of the reservoirs. A processor is connected with the sensors. The processor includes a memory that stores processing instructions to interpret the parameters and to determine a recommended medication to deliver to the patient based on the parameters, the recommended medication being one of the predetermined medications. The processor is operatively connected with the medication pumps. When a recommended medication is determined, the processor actuates the medication pump connected with the reservoir including the recommended medication to deliver the medication to the patient via the manifold and the delivery line.

A non-surgical method of delivering a liquid radioactive solution from a source to a recipient comprising the steps of: determining a desired recipient level of radioactivity and recipient volume of the radioactive solution to be delivered to the recipient, providing a first valve having a waste position and a recipient position, providing a bolus conduit, a waste conduit and a recipient conduit, each conduit having a valve end being connected to said first valve, so that the first valve can establish a waste flow path in the waste position and a recipient flow path in the recipient position, the recipient flow path being different from said waste flow path, the bolus conduit comprising a measuring section and an internal volume, the internal volume being approximately equal to the desired recipient volume of the radioactive solution to be delivered to the recipient, arranging said first valve in the waste position, transporting a first amount of said radioactive solution through said waste flow path, the first amount of said radioactive solution having an initial level of radioactivity that is at least approximately equal to or higher than the desired recipient level of radioactivity and an initial volume that is larger than the internal volume of said bolus conduit, providing a radiation detector, the radiation detector being operable to measure a level of radioactivity of the radioactive solution in said measuring section, measuring a reference level of radioactivity of said radioactive solution present in said measuring section, wherein when the reference level of radioactivity is approximately equal to an injection level of radioactivity, the method further comprises the steps of: arranging the first valve in the recipient position, and transporting the radioactive solution present in the bolus conduit through the recipient flow path.

Some embodiments provided herein relate to methods, systems and kits for providing consistent intracoronary administration of a biologic to subjects having diverse coronary anatomies. In some embodiments, the biologic is an adeno-associated virus serotype 1 (AAV1) vector encoding sarcoplasmic/endoplasmic reticulum ATPase 2a (SERCA2a) protein.

A non-surgical method of delivering a liquid radioactive solution from a source to a recipient comprising the steps of: determining a desired recipient level of radioactivity and recipient volume of the radioactive solution to be delivered to the recipient, providing a first valve having a waste position and a recipient position, providing a bolus conduit, a waste conduit and a recipient conduit, each conduit having a valve end being connected to said first valve, so that the first valve can establish a waste flow path in the waste position and a recipient flow path in the recipient position, the recipient flow path being different from said waste flow path, the bolus conduit comprising a measuring section and an internal volume, the internal volume being approximately equal to the desired recipient volume of the radioactive solution to be delivered to the recipient, arranging said first valve in the waste position, transporting a first amount of said radioactive solution through said waste flow path, the first amount of said radioactive solution having an initial level of radioactivity that is at least approximately equal to or higher than the desired recipient level of radioactivity and an initial volume that is larger than the internal volume of said bolus conduit, providing a radiation detector, the radiation detector being operable to measure a level of radioactivity of the radioactive solution in said measuring section, measuring a reference level of radioactivity of said radioactive solution present in said measuring section, wherein when the reference level of radioactivity is approximately equal to an injection level of radioactivity, the method further comprises the steps of: arranging the first valve in the recipient position, and transporting the radioactive solution present in the bolus conduit through the recipient flow path.

Devices for cleaning a tube or clearing a blockage from a tube, such as an enteral feeding device are provided. The devices include an actuator and a syringe. The actuator is releasably attached to the syringe in a manner that allows the actuator to transition the syringe from a compressed position to an extended position, and vice-a-versa, without requiring the intervention of a user. A method of cleaning a tube or clearing a blockage in a tube is also provided. The tube cleaning device is filled with a liquid and the actuator pushes the liquid from the syringe into the tube when transitioning into a compressed position, and withdraws the liquid back into the syringe when transition into an extended position, causing the liquid to contact a blockage, and clear the blockage and/or clean the tube.