In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components. The device includes a plurality of modules, each including: a body having an interior volume; a spike plate movably disposed in the interior volume, the spike plate having a protruding cannula and first and second ports. The device also includes a base tray which includes: a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules; for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well; passageways to connect certain wells with adjacent wells to permit fluid flow therebetween. For each of the wells, the spike plate of the respective module being maintained in a stationary position with the module being inserted into the well.

The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

A fluid delivery Y-site is described that is configured to receive and control delivery of two or more fluid flows. Fluid flow is controlled within a chamber by a valve and float. Flow of a primary fluid into the chamber is reduced or halted by the movement of a valve. The valve may occlude a first flow port into the chamber in response fluid flowing from a second flow port into the chamber. A float is moveably disposed within the chamber and configured to engage the valve in response a fluid flow into the chamber from the second flow port. As fluid flow from the second flow port into the chamber is reduced or ceases, the valve and float allow the flow from the first flow port to once again enter the chamber and exit from an outlet port.

The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

Provided herein are systems and methods for monitoring one or more health or physiological parameters in a subject. The systems and methods may comprise a patch coupled to an injector. Data may be transmitted to a mobile device or remote server, where the data may be processed. Processed data may be used to inform a subject on a health or physiological condition.

There is described a patch pump comprising a cartridge, a power source, a pump system, a drug delivery device and a control system configured to operate in particular the pump system and the drug delivery device. The pump system comprises, on the one hand, a pump having a pump housing containing a pump piston and a valve piston and, on the other hand, a pump drive comprising a piston motor and a valve motor for driving the pump piston and the valve piston independently from each other through a first and a second transmission. The drug delivery device comprises a transdermal delivery system having a needle actuation mechanism configured for transdermal insertion of a cannula.

A fluid delivery Y-site is described that is configured to receive and control delivery of two or more fluid flows. Fluid flow is controlled within a chamber by a valve and float. Flow of a primary fluid into the chamber is reduced or halted by the movement of a valve. The valve may occlude a first flow port into the chamber in response fluid flowing from a second flow port into the chamber. A float is moveably disposed within the chamber and configured to engage the valve in response a fluid flow into the chamber from the second flow port. As fluid flow from the second flow port into the chamber is reduced or ceases, the valve and float allow the flow from the primary flow port to once again enter the chamber and exit from an outlet port.

A system for providing multiple infusions to a patient (P), the system comprises a multiplicity of infusion devices (10) for administering a multiplicity of medical fluids through an infusion line (102) of an infusion set (103) to the patient (P), and a control device (2) for controlling the multiplicity of infusion devices (10). Herein, the control device (2) comprises a multiplex module (22) configured to multiplex the multiplicity of medical fluids for a multiplexed administration of the medical fluids through said infusion line (102) of the infusion set (103), the multiplex module (22) comprising a scheduling module (222) configured to define at least two packets, each packet comprising at least one medical fluid out of the multiplicity of medical fluids, and to arrange the at least two packets in a sequence for administration of the medical fluids of the at least two packets. In this way a system for providing multiple infusions to a patient is provided which allows for an efficient, yet reliable administration of multiple infusions while at the same time reducing the risks for errors. An advantage of multiplexing is reduction of the number of lumens with associated reduction of infection risks and discomfort.

An intradermal fluid delivery device that uses a processor controlled electromechanical delivery mechanism is provided. An air pump pushes fluid containing medication or saline from a fluid compartment through a microneedle array into a person's skin. The processor repeatedly turns the air pump on or off, for the fluid to gradually be injected into the person's skin. The processor may be configured to control the total fluid delivery time as well as the granularity of the fluid delivery. The total fluid delivery time may be set to T, and the time period T may be divided into smaller periods t.sub.1 to t.sub.n, where the fluid may be administered in a period t1, the fluid delivery may then be stopped for a period t2, followed by another fluid delivery period, etc. The periods t1 to tn may be the same or of different lengths.

An intravenous (IV) fluid delivery system include an IV bag and a fluid delivery device. The IV bag is made of many fluidic channels that keep the fluid distributed across the bag such that the bag may be easily and comfortably wrapped around the arm and shoulder of a person. The fluid delivery device includes a processor controlled electromechanical delivery mechanism that controls a positive displacement pump. The pump moves the fluid into a tube and a needle that is connected to a person's vein. The processor repeatedly turns the pump on or off to gradually transfer the fluid from the IV bag into the person's vein. The processor controls the granularity of the fluid delivery, where the fluid may be administered in a fluid delivery period, the fluid delivery may then be stopped in a subsequent fluid stoppage period, followed by other fluid delivery periods.