An approach for determining material compatibility for components of a drug delivery system is provided that includes using surface zeta-potential analytical method to evaluate surface interactions between a desired molecule and at least one material present within a given IV-bag system.

Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.

Infusion devices and related medical devices, patient data management systems, and methods are provided for monitoring a physiological condition of a patient. An exemplary infusion device includes an actuation arrangement operable to deliver fluid to a user, a communications interface to receive measurement data indicative of a physiological condition of the user, a sensing arrangement to obtain contextual measurement data, and a control system coupled to the actuation arrangement, the communications interface and the sensing arrangement to determine a command for autonomously operating the actuation arrangement in a manner that is influenced by the measurement data and the contextual measurement data and autonomously operate the actuation arrangement in accordance with the command to deliver the fluid to the user.

A multi-use disposable set (MUDS) has at least one syringe having a proximal end and a distal end spaced apart from the proximal end along a longitudinal axis. The MUDS further has a plunger reciprocally movable within a syringe interior between the proximal end and the distal end. A manifold is in fluid communication with the distal end of the at least one syringe. At least one valve is in fluid communication with the syringe interior. The at least one valve is operable between a filling position for filling the syringe interior with fluid and a delivery position for delivering the fluid from the syringe interior. At least one connection port is in fluid communication with the manifold and the syringe interior when the at least one valve is in the delivery position. A multi-fluid delivery system having the medical connector and MUDS is also provided. Various features of the MUDS system are also described.

A medicinal infusion system includes a safety valve for isolating residual medication by providing a single point of fluidic disconnect to encapsulate a residual fluid volume prone to spillage. The safety valve couples a medicinal repository such as an infusion pump to a medicinal supply, typically from a syringe or tubing. The safety valve includes a resilient, deformable, or hinged surface for isolating and sealing the medicinal flow to eliminate and/or isolate any residual volume in tubing and connectors. The isolating surface accommodates an inserted fitting or coupling for allowing the medicinal flow to fill the infusion pump. Upon disconnection, fluids on either side of the safety valve are therefore isolated on the respective fill or source sides, and residual volume prone to spillage is eliminated.

A low medicament sensor for a medicament delivery device having a reservoir, a pump, and a fluid path therebetween for medicament, the sensor including a switch and a snap dome. The snap dome is initially in contact with the switch, in fluid communication with the fluid path, and configured to snap out of contact with the switch when a pressure within the snap dome decreases below a predetermined pressure.

An apparatus, system and method for regulating fluid flow are disclosed. The apparatus includes a flow rate sensor and a valve. The flow rate sensor uses images to estimate flow through a drip chamber and then controls the valve based on the estimated flow rate. The valve comprises a rigid housing disposed around the tube in which fluid flow is being controlled. Increasing the pressure in the housing controls the size of the lumen within the tube by deforming the tube, therefore controlling flow through the tube.

The present disclosure provides a new and innovative method and system for flow rate compensation in devices, such as medical devices and other electronic devices. In various embodiments, a computer-implemented method includes dispensing, by a pump controlled by a controller, a fluid from a fluid supply in a pulse mode over a period by determining a pulse volume for a pulse, determining a pulse cycle time, and for the period: controlling the position of the pump to perform a delay and perform a pulse to dispense an amount of the fluid, the pulse performed for the pulse cycle time, calculating an overshoot or undershoot of the amount of the fluid dispensed relative to the pulse volume, adjusting the pulse cycle time based on the calculated overshoot or undershoot, and repeating the dispensing until the period has elapsed.

A medicinal infusion system includes a safety valve for isolating residual medication by providing a single point of fluidic disconnect to encapsulate a residual fluid volume prone to spillage. The safety valve couples a medicinal repository such as an infusion pump to a medicinal supply, typically from a syringe or tubing. The safety valve includes a resilient, deformable, or hinged surface for isolating and sealing the medicinal flow to eliminate and/or isolate any residual volume in tubing and connectors. The isolating surface accommodates an inserted fitting or coupling for allowing the medicinal flow to fill the infusion pump. Upon disconnection, fluids on either side of the safety valve are therefore isolated on the respective fill or source sides, and residual volume prone to spillage is eliminated.

Devices, systems, and methods for minimization of backlash in a syringe pump are described herein. Syringe pumps may comprise a syringe including a cylindrical body and a plunger, and a controller. The plunger may comprise a linear gear that may operably couple with a circular gear in the controller. The controller may be configured to bias the circular gear in a biasing rotational direction, thereby positioning the plunger to move towards a biasing translational direction. The methods may comprise determining a backlash compensation amount, determining a fluid transfer movement amount, moving at least one component of the syringe pump the backlash compensation amount and the fluid transfer movement amount in a first direction, and moving the at least one component of the syringe pump a biasing movement amount in a second direction opposite the first direction to re-engage the first gear and the second gear to minimize backlash.