A smart drug injection device is disclosed, comprising a main body, a circuit board, a display, a syringe and a transmission mechanism; the main body comprises an accommodating space and a power button; the circuit board comprises a control unit and a storage unit; the transmission mechanism comprises a motor, a screw rod, a propelling block and a movable clamp, with the control unit electrically connected to the storage unit, the power button, the motor and the display, the motor connected to the screw rod, the propelling block movably arranged on the screw rod, the movable clamp disposed at one end of the propelling block and movable between two positions; the syringe is on one side of the main body and comprises a cylinder and a needle holder, one end of the cylinder has a needle and the other end is assembled with the needle holder.

Ambulatory medical devices that provide therapy to a subject, such as blood glucose control, are disclosed. Disclosed systems and devices can transmit a request to modify blood glucose control therapy delivered to a subject. The request can be transmitted via a voice-activated control system, the ambulatory medicament pump can include a medicament reservoir, a pump controller, a wireless data interface, and/or other elements. The device can receive an indication that the request to modify therapy is approved and, in response to the indication that the request to modify the blood glucose control therapy is approved, instruct the pump controller to modify the blood glucose control therapy delivered to the subject.

Electromechanical actuation systems and related operating methods are provided. A method of controlling an electromechanical actuator in response to an input command signal at an input terminal involves determining a commanded actuation state value based on a characteristic of the input command signal, generating driver command signals based on the commanded actuation state value and an actuator type associated with the electromechanical actuator, and operating driver circuitry in accordance with the driver command signals to provide output signals at output terminals coupled to the electromechanical actuator.

Devices and methods are disclosed for assisting a user of a drug delivery device with an application executing on a mobile computing device. The mobile computing device may receive information from the drug delivery device related to its condition and/or operation and subsequently select an informational and/or instructional prompt to be displayed to the user based on the received information. The mobile computing device may also generate a display in the application including the selected informational prompt and/or the instructional prompt. Accordingly, the user of the drug delivery device can be guided through the drug delivery process in real time, thereby reducing the likelihood of improper or incomplete use of the drug delivery device.

The present disclosure relates to a medical diagnostic and delivery device that includes a mouthguard, a dental brace or a denture. The device can be positioned within a mouth or a buccal cavity of a user. A housing of the device can be shaped to be removably secured within the buccal cavity of the user, for example, include grooves shaped and sized to match a dental bite of the user. The device includes a cartridge containing one more substances or medications configured to be delivered to a user in the form a liquid, particles, or fine mist. Any suitable first air medication can be contained within the cartridge such as epinephrine, blood thinners, painkillers, vitamins or any other suitable drugs for limiting the extent of injury.

An alternate mode for addressing meals in closed loop insulin delivery systems is disclosed. An Eating Soon Mode may be a user-selectable feature that can be activated when a user anticipates eating a meal in the near future. Once activated, Eating Soon Mode preemptively modifies the closed loop algorithm in preparation for the expected rise in glucose levels from consumption of the meal. This can result in a greater amount of time in range for the user, a lower coefficient of variation of the user's glucose levels and/or a lower maximum BG level for the user. According to embodiments disclosed herein, activation of Eating Soon Mode modifies the algorithm to deliver a correction bolus to lower the user's glucose level and to provide a modified, lower target range at which to maintain the user's glucose levels in anticipation of the glucose rise that will result from the meal.

Methods of insulin delivery may include Selecting a basal insulin delivery rate responsive to a projected blood glucose level that approximates a target blood glucose level. Methods of insulin delivery may further include generating insulin delivery instructions for an insulin delivery device, the insulin delivery instructions corresponding to the basal insulin delivery rate and for a variable time duration relative to an intended time duration.

Disclosed herein are systems and methods for automated insulin delivery that provide an Alternate Normal Activity Mode that has a lower and narrower target range than the standard range employed in Normal Mode. The Alternative Normal Mode can be a user-selectable feature that provides more aggressive glucose level control that is designed to decrease hyperglycemia without significantly increasing the risk of hypoglycemia. For example, Normal Mode may employ a standard glucose range between which the closed loop algorithm attempts to maintain the user's glucose levels such as 112.5 mg/dL to 160 mg/dL and Alternative Normal Mode may employ a lower and narrower range such as 90 mg/dL to 130 mg/dL. Alternative Normal Mode can also employ a lockout feature that is activated when glucose is high, but is falling rapidly.

A drug-delivery device comprising a drug-reservoir assembly, displacement-generating actuator, and drug administration unit is described, wherein the drug-reservoir assembly comprises at least one flexible wall and a constraining ring, such that the displacement generated by the actuator collapses a flexible wall of the assembly expelling the drug contents of the drug-reservoir towards said drug administration means.

Drug delivery system including: a reservoir having a meander shape or spiral shape, the reservoir including an inlet and a filter; a capacitance measurement device configured to determine a parameter of the reservoir; and a micropump configured to deliver a fluid from the reservoir to an outlet.