A medical device system and related method of automatically adjusting parameters of an insulin delivery controller of an insulin infusion device are disclosed. The methodology obtains therapy-related data associated with operation of the insulin infusion device for a number of days in the past, including sensor glucose data associated with glucose levels of the user, and meal data associated with identified meals. The obtained therapy-related data is processed to generate a suitable pharmacokinetic/pharmacodynamic (PK/PD) model of the user, wherein the PK/PD model fits at least some of the sensor glucose data obtained for the user. The PK/PD model can be used to calculate at least one adjusted parameter of the insulin delivery controller, based on additional therapy-related data associated with further operation of the insulin infusion device. The insulin delivery controller can be instructed or controlled to adjust its settings in accordance with the model-calculated parameters.

Embodiments of the invention include a medicament device configured to provide stepwise instructions for using the device to a user in a particular sequence is provided. The device includes a device housing configured to receive a container, the housing including a control interface, the control interface including at least one responsive member reactive to a user input, an actuation mechanism configured to interact with the container, a signal output component associated with the device housing, and circuitry associated with the device housing configured to control a provision of the stepwise instructions to the user in the particular sequence. The container includes a first housing for containing a medicament, a second housing, and an injection member, wherein the first and second housings are movable relative to one another. The container further includes an injection member which is retractable within the second housing to prevent an unintentional contact with the injection member.

The invention relates to a trainer device for an autoinjector, comprising: a housing; a collet holder comprising a track; a safety cap removably connected to the collet holder; a cover member; a flex stem having flex arm; a cover member locking mechanism; and a resetting mechanism. The cover member further comprises a plastic sleeve or an elastomeric sleeve to prevent or inhibit the obstruction of the movement of cover member when the user accidentally holds the cover member during the actuation of trainer device.

Pump cassettes, infusion systems, and methods are described. An example infusion pump system may include a cassette recess with one or more valve actuators that extend through a surface of the cassette recess to operate a corresponding valve in a fluid passageway of a pump cassette mounted in the cassette recess. The valve actuator may include a base portion, a shaft extending from the base portion through the surface, and a spring disposed on the shaft and extending along a portion of the shaft. The spring may be disposed interior to the back surface. The system may include first and second valve actuators configured to operate corresponding first and second valves located on opposing sides of a pump chamber of the fluid passageway. A piston may be configured to cooperate with the first and second valve actuators to pump a fluid through the fluid passageway.

Pump cassettes, infusion systems, and methods are described. An example pump cassette may include a rigid body comprising a frame portion, a base portion, a compliant membrane disposed substantially therebetween, and two opposing longitudinal edge sections. The rigid body may include a controllable fluid pathway defined in part by the compliant membrane and extending from an inlet port to an outlet port. The pump cassette may include a slider coupled to the two opposing longitudinal edge sections and longitudinally articulable with respect to the rigid body.

A diabetes management system including a pump for dispensing a medicant and a control device for controlling the pump includes a user interface for controlling functions of the pump and providing information related to operation of the pump and other information. The user interface can display blood glucose information and insulin dosing data such that a user can appropriately act on the information and/or gain confidence that the diabetes management system is operating appropriately to manage the disease. User interfaces provided herein can include displays of current and projected glucose values, bolus calculators, charts displaying glucose levels and/or insulin delivery data, system maintenance reminders, system status information, patient configuration input screens, and log-in screens. Diabetes management systems can include insulin pumps, continuous glucose monitors, blood glucose monitors, mobile computing devices, servers, and/or other insulin delivery devices (e.g., insulin pens).

Pump cassettes, infusion systems, and methods are described. An example pump cassette may include a rigid body including two opposing edge sections, an inlet port, an outlet port, and a controllable fluid pathway extending from the inlet port to the outlet port. The pump may include a slider coupled to the two opposing edge sections and articulable with respect to the rigid body; and a flow stop valve operably coupled to the controllable fluid pathway.

Impact testing apparatuses are disclosed which simulate and measure various impact-related events associated with the operation of a drug delivery device. The impact testing apparatus may include an impactor configured to simulate a plunger rod of the drug delivery device, and a guide sleeve configured to receive a syringe corresponding to the drug delivery device. The syringe may have a proximal end, a distal end defining an outlet, and an interior chamber extending between the proximal and distal ends and carrying a plunger. Additionally, the impact testing apparatus may include an energy source configured to reduce a distance between the impactor and the plunger so that the impactor strikes the plunger. Various sensors may be included to measure characteristics of one or more impacts caused by the impactor. Methods of impact testing a syringe filled with a fluid and carrying a plunger are also disclosed.

Provided are an insulin patch control method and apparatus. An insulin patch control method according to an embodiment of the present disclosure includes obtaining blood sugar information measured by a blood sugar sensor, from the insulin patch, inputting the obtained blood sugar information to a first neural network, estimating a pump parameter of the insulin patch based on output data from the first neural network, and performing a simulation of the insulin patch by inputting the blood sugar information and the pump parameter into a second neural network.

A diabetes management system including a pump for dispensing a medicant and a control device for controlling the pump includes a user interface for controlling functions of the pump and providing information related to operation of the pump and other information. The user interface can display blood glucose information and insulin dosing data such that a user can appropriately act on the information and/or gain confidence that the diabetes management system is operating appropriately to manage the disease. User interfaces provided herein can include displays of current and projected glucose values, bolus calculators, charts displaying glucose levels and/or insulin delivery data, system maintenance reminders, system status information, patient configuration input screens, and log-in screens. Diabetes management systems can include insulin pumps, continuous glucose monitors, blood glucose monitors, mobile computing devices, servers, and/or other insulin delivery devices (e.g., insulin pens).