Methods, devices, and components are provided to reduce tissue resistive pressure during a subcutaneous drug delivery operation by increasing the size of the injection cavity by partially retracting the drug delivery member after inserting the drug delivery member to a subcutaneous position. The drug delivery devices described herein include a motor operably coupled to a drug delivery member. The motor can be selectively activated by a controller to retract the drug delivery member a predetermined distance to relieve pressure in an injection cavity in a patient. A force sensor can provide the controller with a drug delivery member insertion force. The controller can then estimate a tissue resistive pressure based on the drug delivery member insertion force and determine the predetermined distance for the partial drug delivery member retraction based on the tissue resistive pressure.

A delivery system of a portable delivery device, using a chamber with three connections structure (10) arranged on the upper housing (1) as a buffer channel for the flow passage of the drug fluid from the external syringe into the reservoir (6) and from the reservoir (6) into the infusion needle; and the structures on the upper, the lower housings (1), (4) and the needle seat (2) accommodating the infusion needle mate with each other sophisticatedly ensuring the compactness of the delivery device and enabling the patient to control the position of the infusion needle safely and conveniently at the same time; in additional, the needle seat cover (7, 8) which covers the needle seat (2) enhances the safety of using the infusion needle. The delivery system of a portable delivery device has advantages of small size, sophisticated structure, simple operation, safety guarantee.

An infusion device configured to implant a cannula and a sensor in a user. The infusion device includes a first unit defining a first housing and a second unit defining a second housing. The second housing is configured to engage the first housing. The infusion device includes a first insertion needle configured to implant the cannula in the user and a second insertion needle configured to implant the sensor in the user when the second unit engages the first unit. The infusion device includes processing circuitry in electrical communication with the sensor and a fluid reservoir in fluid communication with the cannula. In examples, the first unit and the second unit are configured to engage using an inserter.

A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.

A catheter insertion device and method for insertion. The catheter insertion device can include a housing, a needle attached to a needle carrier, a catheter including a catheter shaft attached to a catheter hub, and a guidewire. The guidewire can include a coil tip positioned in a lumen of the needle. The method for insertion can include inserting a distal end of the needle and the catheter shaft into a blood vessel of a patient, advancing the coil tip out of the needle lumen and into the blood vessel, advancing the catheter over the guidewire, and withdrawing the guidewire and the needle from the catheter. The coil tip can include a straightened configuration and a coiled configuration. The coil tip can transition from the straightened configuration in the needle lumen to the coiled configuration in the blood vessel.

A drug delivery device (1) comprising a delivery unit (2) receiving a drug cartridge (3) containing a drug to be administered to a patient in need thereof, the delivery unit comprising a subcutaneous delivery mechanism (7) including a needle (24), a needle support (8) to which the needle is mounted, and a needle actuation mechanism (9) configured to move the needle from a retracted position within a housing (5) of the delivery unit (2), to an extended delivery position where the needle projects through a base wall (14) of the housing. The needle actuation mechanism comprises a rotary actuator (10) configured to engage an engagement lever (11) coupled to the needle support (8) for translating the needle support between retracted and extended delivery positions.

An insertion mechanism for a wearable drug delivery device that deploys a small gauge flexible cannula with support of a coaxial rigid trocar or hollow needle. After insertion, the trocar or hollow needle is withdrawn leaving the cannula in place for drug delivery. The insertion mechanism may also include an insertion mechanism housing having a proximal and distal end, a manifold configured to fluidly connect the hollow interior of the cannula and the fluid pathway connector, and a manifold guide carrying the manifold and movable between a first position and a second position. A hub carries the trocar and is removably connected to the manifold guide. An insertion biasing member may be initially retained in an energized state between the proximal end of the insertion mechanism housing and the hub, and a retraction biasing member may be initially retained in an energized state between the hub and the manifold guide.

A therapeutic substance delivery device includes a fluid path having a reservoir needle, a body needle, a body needle injection mechanism, and a pumping assembly (a) configured to pump the substance from the reservoir to the subject, (b) shaped to define a pump chamber, and (c) including a plunger disposed within the pump chamber. The plunger moves back and forth through a plurality of discrete motion phases. A first motion phase of the plunger actuates a first operation from a group of operations including (a) driving the reservoir needle to penetrate the reservoir, (b) advancing the body needle into the body of the subject, (c) withdrawing the substance from the reservoir, (d) pumping the substance into the subject, and (e) retracting the body needle. A second motion phase of the plunger actuates a second operation from the group of operations. Other applications are also described.

A manually-retractable intravenous infusion needle assembly, including a needle holder, a needle tube, a built-in slidable sheath and a protective casing, where the needle holder includes a tubular portion and a tailstock portion; a rear end of the needle tube is mounted inside the tubular portion; the built-in slidable sheath is through and elongated and has a C-shaped cross-section; the tubular portion is mounted inside the built-in slidable sheath and can slide back and forth; the protective casing is an elongated, through and hollow casing; the built-in slidable sheath is mounted inside the protective casing. A locking structure is provided between the needle holder and the protective casing.

An insertion mechanism for a drug pump includes an insertion mechanism housing; a sleeve; a rotational biasing member initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the sleeve. The needle is inserted into a target tissue by the rotational biasing member and interaction between the hub and housing. Retraction of the needle is caused by decompressing or de-energizing of the retraction biasing member. A drug delivery pump includes an activation mechanism, a drive mechanism, a sterile access connection, and the insertion mechanism. Assembly and operation methods are provided.