The present disclosure is generally directed to a delivery device housed within an outer cartridge and useful for delivering a fluid to the IO space of a subject at a relatively constant volumetric flow rate over an extended period of time. The delivery device may be fluidly coupled to an existing IO access device or IV line positioned in the IO space of the subject or may be coupled to an IO access device disposed within the outer cartridge.

A garment (e.g., a shirt) for monitoring biometric properties of the wearer of the garment is disclosed. The garment may include sensors for monitoring or assessing the vital signs and body position of the wearer. A processor associated with the garment may provide an output indicative of an assessed condition of the wearer based on the assessed vital signs and the assessed body position of the wearer of the fabric. The garment may include an injector assembly that is used to administer a drug injection to the wearer when the assessed condition indicates that the wearer is in an alert condition.

Described here are systems and methods for accessing Schlemm's canal, for delivering a fluid composition therein, and for tearing the trabecular meshwork. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. The systems described here may be configured to cut or tear the trabecular meshwork with the body of an elongate member located within Schlemm's canal.

Needle insertion mechanisms include a housing and a needle holder, the needle holder being linearly guided by the housing to be moved along the needle-axis. A slider linearly guided by the housing and transversally moveable with respect to the needle-axis from a first to a second slider position. The needle holder is operatively coupled to the slider when the slider is in the first position, thereby retaining the needle holder in a retracted position against the bias of a spring acting on the needle holder. In the second position the slider is decoupled from the needle holder and the holder is moved into an inserted position by the spring. A blocking member arranged between the slider and the housing blocking movement of the slider into the second position, is moved by an active drive thereby unblocking the movement of the slider and subsequently moving the slider to the second position.

A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, a needle insertion mechanism, a fluid flow connection, and a valve in fluid communication with the fluid flow connection and the needle insertion mechanism. The container has an inner volume to contain a medicament which is urged out of the container by the activation mechanism. The needle insertion mechanism is adapted to insert a needle and/or a cannula to deliver the medicament from the container via the fluid flow connection. The valve is in fluid communication with the fluid flow connection and needle insertion mechanism, and is movable between first and second positions. Upon insertion of the needle and/or the cannula, the valve remains in the first position whereby fluid flow is restricted. At a later time, the valve is urged to the second position whereby fluid may flow through the needle or cannula.

Fluid communication devices and supporting structures may be provided for use with intraosseous devices. Apparatus and methods may also be provided to communicate fluids with an intraosseous device.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Sensors are disclosed that detect whether a cannula is properly inserted to its full depth in a subject's skin. The sensors may be used with a blood glucose monitor, or with a continuous insulin infusion pump, infusion set, or other system involving intermittent or continuous testing and/or drug delivery.

A system for facilitating instrument delivery through a peripheral intravenous catheter may include a catheter adapter having a proximal end, a distal end, and a lumen extending there through. The catheter adapter may include a side port. The system may include an extension tube extending from the side port. The system may include a blood control valve disposed in the lumen of the catheter adapter. The system may include a peripheral intravenous catheter extending distally from the catheter adapter.