Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage with a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components.

An inserter assembly that has a base, a needle, an inner part that selectively transitions the needle from a retracted position substantially within the base to an extended position where at least a portion of the needle extends outside of the base, and an insertion angle component. As the inner part of the inserter assembly transitions from the retracted position to the extended position, the needle is at least partially deflected by the insertion angle component.

An automatic needle insertion device assists patients who may be uncomfortable with placing the needle themselves and employs a soft outer needle inserted using a rigid stylet, for example, a standard hypodermic needle, which is then removed after the soft needle is placed, greatly reducing irritation. An ambulatory pump can be filled with a variety of drugs and different amounts of drug on demand, for example, using a syringe prior to use.

Various embodiments pertain to syringes having needles that automatically retract, and including syringe assemblies in which there is a means for damping any impact of the retracting needle, slowing the retracting needle, dissipating the kinetic energy of the needle, or the like, so as to lessen any jolt or disturbance experienced by the user.

An apparatus for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices. Embodiments include removing a substantially cylindrical cap from an inserter to expose a substantially cylindrical sleeve, removing a cover from a substantially cylindrical container holding sensor components, and fitting the sensor components into the inserter.

A medicament delivery device comprises a needle configured to move between a retracted position and an inserted position; an insertion mechanism to move the needle from the retracted position to the inserted position when activated; a locking arm which, in a locked position, is engaged with the insertion mechanism to prevent activation of the insertion mechanism and, in an unlocked position, is disengaged from the insertion mechanism; a retraction mechanism to move the needle from the inserted position to the retracted position when activated; and a trigger configured to move between a disengaged position and an engaged position. On moving from the disengaged position to the engaged position, the trigger is configured to move the locking arm from the locked position to the unlocked position. On moving from the engaged position to the disengaged position, the trigger is configured to activate the retraction mechanism.

Provided is an extended use self-contained, wearable medical device. The device is preferably configured with an infusion deployment mechanism for variably inserting and retracting an infusion needle to different depths, or completely retracting the infusion needle from the infusion site and then re-inserting the infusion needle after a predetermined period of time, throughout an infusion cycle for extending the viability of the infusion site. Another embodiment comprises dual needle deployment mechanisms which may also variably insert and retract the infusion needles. A flow sensor is preferably provided for detecting the stoppage of flow through the infusion cannula and signaling the needle deployment mechanism to attempt infusion at a different depth or to deploy a second infusion needle. A re-fillable reservoir assembly is preferably provided for supplying a drug over the extended use of the device. Another embodiment comprises a partially reusable and partially disposable medical device implementing the above features.

A fluid connector assembly. The fluid connector assembly includes a tab portion including a slot; a plug portion slidably connected to the tab portion the plug portion comprising a fluid path and a disc, the disc configured to seat within the slot; a catch feature located on a first end of the tab portion and configured to interact with a reservoir; and a latching feature located on a second end of the tab portion, the latching feature configured to interact and lock onto the reservoir, wherein force applied to the plug portion may overcome a threshold force and unseat the disc from the slot wherein the plug portion moves with respect to the tab portion.

Briefly, a kinkless infusion set has a setting control that engages a curved or helical cannula to simultaneously rotate the helical cannula as the helical cannula is moved toward a patients skin and then under the patient's skin to position the curved or helical cannula to a desired depth and position. In one example, the helical cannula is set between 3 mm and 5 mm under the patient's skin. Also, the curved or helical cannula may have side ports to allow medicine to be presented over a larger area for more effective therapeutic treatment. In some constructions the patient rotates the setting control, and in other cases the patient may push, pull or translate the setting control.

A method of dispensing fluid includes three processes. A first one of these processes includes pumping fluid into a resilient variable-volume dispensing chamber. The dispensing chamber is in series with a normally present finite fluid impedance and an output. The impedance is sufficient so as to cause expansion of the dispensing chamber as it receives pumped fluid even while some fluid flows through the output. Another one of these processes includes repeatedly measuring a parameter related to volume of the dispensing chamber over time. A third one of these processes includes controlling the pumping of fluid based on repeated measurements of the parameter to produce a desired fluid flow through the output. A corresponding system for dispensing fluid implements these processes.