Described herein are devices and methods for performing automated and minimally invasive intramyocardial injections for cardiac repair that eliminate the need for opening the chest cavity for injections of therapeutics to the heart muscle to address heart attack, cardiomyopathy or myocardial diseases and can detect diseased tissue and deliver a specified volume of a therapeutic injectate to the region of interest.

In some embodiments, an apparatus may comprise a first insertion needle and a second insertion needle. The first insertion needle may be configured to carry a first medical device (e.g., a sensor) through an opening in an apparatus housing. The second insertion needle may be configured to carry a second medical device (e.g., a cannula) along a curved path that passes through the opening in the apparatus housing such that a distal end of the first medical device becomes increasingly displaced from the distal end of the second medical device as the distal end of the second medical device is carried along the curved path.

Tissue access devices and methods of using the same are disclosed. The devices can have a sensor configured to occlude a flow path by deflecting a membrane into the flow path when the devices become dislodged from tissue. The sensor can be configured to partially or fully occlude the flow path. The sensor can have a spring. The spring can be biased to move the sensor from a sensor first configuration to a sensor second configuration when a force applied by the sensor first surface against a non-sensor surface changes from a first force to a second force less than the first force. The membrane can be deflected into the flow path when the sensor is in the sensor second configuration.

A marking assembly includes a hollow cannula having a wall extending from a proximal end to a distal end. The wall defines a lumen of the cannula. The wall includes at least one opening at a distal portion of the cannula. A stylet is configured to be received in the lumen of the cannula. The stylet has a wall extending from a proximal end to a distal end. When the stylet is received in the lumen of the cannula, a circumferential space is defined between the wall of the stylet and the wall of the cannula such that fluid entering the circumferential space will exit the cannula through the at least one opening of the cannula.

A medical device includes a hub and an adhesive patch coupled to the hub. The adhesive patch is to couple the hub to an anatomy. The adhesive patch defines an edge that extends along a perimeter of the adhesive patch. The medical device includes an anisotropic shim coupled to the adhesive patch along the perimeter of the adhesive patch proximate the edge to resist an uncoupling of the adhesive patch from the anatomy. The anisotropic shim has an inner periphery spaced apart from an outer periphery and the anisotropic shim is locally rigid between the inner periphery and the outer periphery.

There is described a patch pump comprising a cartridge, a power source, a pump system, a drug delivery device and a control system configured to operate in particular the pump system and the drug delivery device. The pump system comprises, on the one hand, a pump having a pump housing containing a pump piston and a valve piston and, on the other hand, a pump drive comprising a piston motor and a valve motor for driving the pump piston and the valve piston independently from each other through a first and a second transmission. The drug delivery device comprises a transdermal delivery system having a needle actuation mechanism configured for transdermal insertion of a cannula.

An infusion device. The infusion device includes a top portion comprising an introduction needle, and a bottom portion comprising a cannula, the top portion removably attached to the bottom portion, wherein the introduction needle is used to insert the cannula, and wherein after insertion, the top portion is removed from the bottom portion.

An antimicrobial light dressing device, system and method for a percutaneous treatment that bathes a treatment region around the percutaneous insertion with an antibacterial illumination source for preventing pathogens around the insertion from entering via the dermal puncture created by the insertion. The antimicrobial light dressing device combines a circumferential body centered around the insertion, and an arrangement of LEDs around the body that focus the light around the insertion and onto a therapeutic region of the insertion. An opening in the circumferential body has an articulated protrusion for offsetting a medicinal vessel such as an IV tube off the skin surface to avoid blocking light to an area under the vessel.

A delivery device is provided for introducing a fluid to a patient. The delivery device has a base with a bottom face for attaching to the skin of the patient, and a cannula extending from the bottom face for penetrating the skin of the patient. A fluid supply conduit has a first lumen connected to the cannula for supplying the fluid to the cannula, where the fluid contains an active agent and stabilizing agent. The conduit has a second lumen with an open end for capturing leakage of the fluid from the infusion site and carrying the fluid away from the infusion site. The second lumen has a leak detector containing a color changing in an amount to react with the stabilizing agent and produce a visual indication to the patient through the conduit. The leak detector is spaced from the infusion site and oriented in a location visible by the patient through the conduit.

An intravenous (IV) catheter system may include a catheter adapter having a proximal end and a distal end. The IV catheter system may also include a cannula extending through the catheter adapter. A proximal end of the cannula may include a notch. The IV catheter system may also include a needle hub, which may be coupled to the proximal end of the catheter adapter. The needle hub may include a flashback chamber, which may be in fluid communication with the notch when the IV catheter system is in an insertion configuration.