Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a patient involves obtaining, by a control system associated with the infusion device, an input meal indication, obtaining historical data for the patient associated with the input meal indication, determining an estimated carbohydrate amount corresponding to the input meal indication based at least in part on the historical data, determining a bolus dosage of the insulin based at least in part on the estimated carbohydrate amount, and operating an actuation arrangement of the infusion device to deliver the bolus dosage of the insulin to the patient.

An occluder detection system is disclosed. At least one occluder element moves according to a cam motion to apply a periodic compression to a flexible infusion line. A portion of the occluder element is configured to emit or modify an energy or magnetic field. A sensor is configured to measure the energy being emitted or modified by the section of the occluder element. A processor causes the at least one occluder element to move according to the cam motion to move a fluid within the flexible infusion line by periodically compressing the flexible infusion line, measures the energy of the energy source via the sensor, obtains a current cam state associated with the cam motion at a time corresponding to the measured energy, and determines, based on the measured energy and the current cam state, a state of the occluder element. The processor may issue an alarm on a fault condition.

A drug delivery system includes a delivery container including a container body adapted to accommodate a drug therein, a supply line, a flow rate sensor, and a flow controller. The delivery container further includes an outlet port and is constructed from a resilient material. The container body is adapted to exert an urging force on the drug to expel the drug from the outlet port. The supply line is operably coupled to the outlet port to deliver the drug to a user. The flow sensor senses a flow rate of the drug within the supply line. The flow controller is configured to regulate a flow rate of the drug; the flow controller includes a supply line restrictor and a controller for adjusting the supply line restrictor between at least two settings.

A filling aid device for filling a reservoir. The device includes a cover portion comprising a septum window; a slider beam comprising a septum cover; and a first filling aid tab attached to the slider beam, the first filling aid tab in slidable relation to the cover from a first position to a second position, wherein when the filling aid device is in an unlocked position, the septum cover is located below the septum window, wherein when the first filling aid tab is moved from the first position to the second position, the septum cover is moved from below the septum window, and the filling aid device is in the locked position.

An infusion pump including a fluid chamber having an outlet valve and a piezo-stack actuator including a stack of piezo-electric layers. The infusion pump also includes a linear actuator to measure displacement of the piezo-stack actuator during operation. An electronic processor is programmed to operate the outlet valve and the piezo-stack actuator to pump fluid through the fluid chamber at a programmed flow rate.

A system and method are provided for detecting air embolisms in lines for hemodynamic monitoring. In use, using a first sensor, one or more gas bubbles are detected within a first line for hemodynamic monitoring. In response to the detecting, a first clamp attached to the first line for hemodynamic monitoring is contracted.

An infusion device includes a pump configured to deliver a fluid in at least a therapy delivery mode and a stand-by delivery mode. The infusion device includes an audible alarm and at least first, second and third sets of visible indicators. The infusion device includes a pump controller coupled to the pump, the audible alarm, and the visible indicators. The pump controller is configured to operate the pump in the therapy delivery mode or the stand-by delivery mode, and to actuate the first set of visible indicators in the therapy delivery mode and the stand-by delivery mode, to actuate the second set and the audible alarm at an end of the therapy delivery mode and at intervals during the stand-by delivery mode, and to actuate the third set during the stand-by delivery mode when the second set is deactivated.

In some embodiments, a device may include an intraventricular access device and an infusion device. The intraventricular access device may include more than one catheter and a container. In some embodiments, the catheter may include an aspiration lumen and an infusion lumen. A distal end of the intraventricular portion of the catheter may be positionable, during use, in a subject's brain fluid. In some embodiments, the container may be coupled to a proximal end of the aspiration lumen. The proximal end of the aspiration lumen may be in fluid communication with the container. In some embodiments, the container may include a barrier positioned between a proximal opening of the aspiration lumen and at least a portion of the infusion lumen adjacent to and/or associated with the container. The barrier may inhibit penetration of a surgical instrument.

An apparatus is provided for detecting mating of a cap with a fluid delivery device having a housing, a receptacle, and a sensor. The housing is configured to carry an insulin delivery device having a reservoir of the fluid. The receptacle is provided by the housing having a coupling with a locking recess configured to receive a cap with a sprung locking arm. The pressure sensor is carried by the receptacle proximate the coupling and configured to detect engagement force of the sprung locking arm with the receptacle when mated with the housing. A method is also provided.

A drive system for a drug delivery device is described. The drive system comprises an axial drive component configured to drive advancement of a stopper sealing a container; a variable rate drive drives advancement of the axial drive component and a controller controls the variable rate drive to deliver a first volume of medicament at a first rate, and a second volume of medicament at a second rate. The controller is configured to: optionally, identify a start point for delivery of medicament from the container, the start point being identified as completion of a predefined preparatory event; drive the variable rate drive at a first speed during a first phase from the identified start point to deliver the first volume of medicament at the first rate; drive the variable rate drive at a second speed during a second phase to deliver the second volume of medicament at the second rate.