Systems and methods for controlling fluid delivery via a manually administrable medication container to a patient through a fluid delivery pathway are provided. The systems and methods described herein incorporate rules-based clinical decision support logic to drive a flow control valve within a flow pathway based on a determination of whether or not an IV fluid connected to an input port on the pathway is appropriate for patient administration by considering such factors as patient-specific clinical circumstances, current medical orders, and accepted delivery protocols. Related apparatus, systems, methods and articles are also described.

A flushing apparatus according to embodiments of the present disclosure includes: a main body configured to connect a connection pipe for guiding a hazardous medicinal liquid harmful to a human body when exposed to an ambient air and a patient connection module for injecting the hazardous medicinal liquid into a patient, the main body configured to form a first flow path for guiding the hazardous medicinal liquid from the connection pipe to the patient connection module, the main body including a flushing portion forming a second flow path connected to a predetermined connection point located between both ends of the first flow path; and a flow rate reduction part disposed at upstream side of the connection point in the first flow path and configured to reduce a flow rate of the hazardous medicinal liquid flowing through the first flow path. The present disclosure shows various embodiments of the flushing apparatus.

An infusion apparatus includes a housing and a chamber configured to be connected to the housing. The apparatus further includes a weight sensor coupled to a load connector connected to the housing and an optical sensor disposed in the housing. The weight sensor is configured to generate a first signal based on a measured weight of the fluid container attached to the housing in a weight-bearing configuration. The optical sensor is configured to generate a second signal based on detecting drops of the fluid traversing the chamber. The apparatus also includes a flow control mechanism to control a flow rate of the fluid into an outlet channel. The apparatus includes one or more processing devices configured to perform operations including transmitting a control signal to the flow control mechanism to adjust the flow rate.

An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

Embodiments of the present disclosure provide a device, an apparatus, and a method for controlling infusion. The device may include a multi-port container assembly and a liquid flow controller. The multi-port container assembly includes a multi-port container having a plurality of inlets and an outlet, a detector configured to detect amount of liquid in the multi-port container, a first communication subassembly, and a first controller. The first controller may send a first signal to the liquid flow controller via the first communication subassembly in response to the detector detecting that the amount of liquid is lower than a first predetermined threshold. The liquid flow controller may turn off a first infusion tube currently used and turn on a next first infusion tube in response to receiving the first signal.

A drug solution administration unit including a drug solution administration module having a first flow path unit, a second flow path unit, and a drive mechanism unit, and a drug solution administration device having a branch path and a main path. The first flow path unit includes an upstream side main body where a first flow path to store drive solution is formed, and the second flow path unit includes a downstream side main body where a second flow path to store drug solution is formed. The drive mechanism unit includes a pair of electrodes and a porous body sandwiched between the pair of electrodes, the drive mechanism unit has a connecting flow path connecting a downstream end of the first flow path and an upstream end of the second flow path.

A closed-loop artificial pancreas system based on a wearable monitoring method is provided. The system includes: a wearable blood glucose monitoring submodule, configured to obtain a blood glucose sensing signal in a noninvasive manner by utilizing a wearable device; a diet and exercise monitoring submodule, configured to obtain diet monitoring data and exercise monitoring data which can cause variations of blood glucose concentration of a subject to be tested; a calculation control submodule, configured to obtain information related to insulin infusion by utilizing a trained deep learning model, the diet monitoring data, and the exercise monitoring data; an insulin infusion submodule, configured to automatically implement insulin infusion; and an effect assessment module, configured to assess an insulin infusion effect, and to feed an assessment result back to the calculation control submodule, such that the calculation control submodule determines whether to update the information related to insulin infusion.

A system for delivering a medicinal fluid to a patient includes a variable volume pressure delivery chamber, a variable volume medication chamber, an optional medication reservoir, a movable delivery element, a fixed reference volume chamber, a pressure source, and a control sub-system. The variable volume pressure delivery chamber is configured to store pressure controllably. The variable volume medication chamber is fluidically isolated from the pressure delivery chamber and is configured to store medicinal fluid. The movable delivery element is disposed between the medication chamber and the pressure delivery chamber. The pressure source is coupled to the pressure delivery chamber. The control system is configured to selectively cause the pressure source to deliver pressure to the pressure delivery chamber causing the movable delivery element to apply pressure to the medicinal fluid in the medication chamber thereby causing the medicinal fluid to exit the medication chamber at an outlet along the fluid communication path to the patient.

An intravenous delivery system may operate by gravity feed, and may have a liquid source containing a liquid, a drip unit that receives the liquid from the liquid source, and tubing that receives the liquid from the drip unit for delivery to a patient. A flow rate sensor may be used to measure a flow rate of liquid through the intravenous delivery system, and may generate a flow rate signal indicative of the flow rate. A controller may receive the signal, and may compare the flow rate with a desired flow rate. If the flow rate is more or less than the desired flow rate, the controller may transmit a control signal to a flow rate regulator. The flow rate regulator may receive the control signal and, in response, modify the flow rate to bring the flow rate closer to the desired flow rate.

Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a patient involves predicting, by a control system associated with the infusion device, a future occurrence of an event based at least in part on historical data associated with the patient, and prior to the future occurrence of the event, automatically adjusting a control parameter for operating the infusion device based at least in part on the event and automatically operating an actuation arrangement of the infusion device to deliver the fluid to the patient based at least in part on a current measurement of the physiological condition and the adjusted control parameter.