An IV flow rate regulator for precision dosage of medical liquids including a first part, a second part with an integrated outlet tubular connector and a mating attachment part with an integrated inlet tubular connector, coupled to one another in a rotatable manner with a first elastic gasket in a depression in the base wall of the second part, a second elastic gasket in a depression in the base wall of the mating attachment part, a dosing passage groove provided between the first and second gaskets, the dosing groove opening progressively the communication between the inlet tubular connector and the outlet tubular connector by rotation of the first and second parts. Also provided is a method for the fabrication of the IV flow regulator.

A unidirectional-driven drug infusion device, includes: a reservoir, a piston and a screw, the piston is arranged in the reservoir; a driving module which includes at least one driving wheel and at least one driving arm that cooperate with each other, the circumferential surface of the driving wheel is provided with wheel teeth; a power module coupled to the driving arm; a control module, connected to the power module, controls the power module to apply different driving powers to the driving arm, making the driving arm perform linear reciprocating motion; and a friction member which is in contact with the surface of the driving wheel. This device can fully utilize the internal space of the infusion device, and its weight and volume is reduced.

A universal flow limiter assembly includes a body configured to receive a portion of an IV tube, where the body includes two opposing side beams, a hinge portion disposed at a first end of the body, a control portion disposed at a second end of the body, a groove defined between the side beams and disposed between the hinge portion and the control portion and a control knob. The universal flow limiter assembly is configured to regulate a flow rate of fluid flowing through the IV tube based on rotation of the control knob. IV sets with universal flow limiter assemblies and methods of operating universal flow limiter assemblies are also provided.

There is provided an IV flow regulator including a first part integrated with a flow control slit, the flow control slit being along a fluid path; a second part integrated with a central stem, the central stem including a spiral surface configured to contact the flow control slit, an area of contact defined by the spiral surface and the flow control slit being shaped substantially like an orifice to enable flow along the fluid path; and a dead space chamfer included in the second part at a portion of the fluid path subsequent to the area of contact.

An IV set corkscrew hand pump includes a body, a corkscrew member disposed in the body, an inlet port disposed on a first end of the body, an outlet port disposed on a second end of the body and a drive mechanism coupled to the corkscrew member. The drive mechanism is configured to cause the corkscrew mechanism to turn within the body to increase fluid flow downstream in an IV set. IV sets with IV set corkscrew hand pumps and methods of operating IV set corkscrew hand pumps are also provided.

An apparatus, system and method for regulating fluid flow are disclosed. The apparatus includes a flow rate sensor and a valve. The flow rate sensor uses images to estimate flow through a drip chamber and then controls the valve based on the estimated flow rate. The valve comprises a rigid housing disposed around the tube in which fluid flow is being controlled. Increasing the pressure in the housing controls the size of the lumen within the tube by deforming the tube, therefore controlling flow through the tube.

An automatic injection device with flow regulation is disclosed. The automatic injection device has an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product and includes a plunger. The automatic injection needle also has a fluid path which fluidly connects the drug container to the patient via an insertion device, a potential energy source, and a regulator configured to restrict release of potential energy and restrict linear movement of the plunger and the pharmaceutical product into the fluid path at a proscribed pace. The regulator includes a clock escapement mechanism. The potential energy source may be a spring that surrounds the drug container and may be magnetically coupled to the plunger. The clock escapement mechanism is configured to control the spring at a regulated rate over a time interval using a gearbox and rotational-to-linear translator comprising a rack and a pinion.

Ambulatory medicament devices that provide therapy to a subject, such as blood glucose control, are disclosed. Disclosed systems and methods can implement one or more features that improve the user experience, by modifying delivery of therapy to a subject after determining that a possible occlusion exists in a medicament delivery system, monitoring the status of an ambulatory medical device and the health condition of a subject that receives therapy from the ambulatory medical device and annunciating alarm condition when necessary, selectively muting alarm annunciations while a Do Not Disturb mode is activated, implementing various power saving modes to save power, controlling operation of the device and medicament delivery based on the user gesture controls, and controlling medicament delivery based on a condition of the ambulatory medicament device.

A method for administering a medicament suitable for treating a migraine or cluster headache to a patient in need thereof includes placing a mounting surface of a fluid delivery apparatus with the medicament in contact with at least a portion of the skin of said patient. A flow rate of the medicament from the fluid delivery apparatus is adjusted such that the medicament is delivered to the patient for at least a predetermined time period. The fluid delivery apparatus includes a controller assembly having a body component defining an axis and a plunger component slidably coupled to the body component. The plunger is positionable between a first position in which the plunger is nearest to the body component and a second position in which the plunger component is furthest from the body component. A bias assembly is positioned between the body component and the plunger component. The bias assembly is configured to apply a two stage force profile to the plunger component. Also disclosed is a method for administering sumatriptan to a patient in need thereof such that the C.sub.max, T.sub.max and AUC are within predetermined, therapeutically effective values.

A drive mechanism (100) for use with a drug container (50) in a drug pump, the drug container (50) having a barrel (58) and a plunger seal (60), including a tether, an electrical actuator (101) and a gear interface. Rotation of the gear interface is controlled by the actuator (101). A gear assembly rotationally engages with the gear interface. The gear assembly includes a main gear and a regulating mechanism. Release of the tether is metered by the gear assembly through the regulating mechanism. A piston (110, 1110, 2110) is connected to the tether and is disposed in the barrel (58) and configured to translate axially within the container. A biasing member is disposed at least partially within the barrel (58) and is retained in an energized state between the piston (110, 1110, 2110) and drive housing, wherein the release of the tether controls the free expansion of the biasing member from its energized state and the axial translation of the piston (110, 1110, 2110).