A therapeutic substance delivery apparatus includes a housing, a reservoir for holding a therapeutic substance disposed at least partially within the housing, a position sensor having at least three states, a plunger which is slidable within the reservoir, and a plunger-sensor engagement interface coupled to the plunger within the reservoir and extending from within the reservoir to outside of the reservoir. The plunger and the position sensor are arranged such that the plunger-sensor engagement interface causes the position sensor to change states as the plunger slides within the reservoir. Control circuitry identifies a new state indication of the apparatus based on (a) a change in state of the position sensor, or (b) a previous or current state of the apparatus in combination with a threshold amount of time having elapsed without the position sensor changing state. Other applications are also described.

In one embodiment, a fluid storage device includes a rigid outer housing that defines a septum cavity, a reservoir cavity, and a channel that extends between the two cavities, the outer housing further defining an outlet in fluid communication with the reservoir cavity, a septum provided within the septum cavity, the septum being made of an elastic polymer and facilitating refilling of the fluid storage device, and a thin, collapsible membrane that does not generate significant restoring forces when it is deformed as fluid is drawn from the reservoir cavity and, therefore, does not completely or partially return to its initial non-deformed shape even if the outlet of the device remains open after doses are administered.

The present invention relates to a device for injecting a material, the device comprising the laser generation unit generates laser beams at a repetition rate of 15 to 25 Hz such that an inject material is injected so as to penetrate into skin through the surface of skin. As described above, a device for delivering a material by applying an optimum inject cycle according to the present invention is advantageous in that a material can be injected at an optimum inject cycle and made to penetrate into skin without a needle, thereby improving the penetration efficiency and minimizing the residual material which has failed to penetrate.

A drug delivery device comprising a delivery unit (2) including an internal reservoir (8), a subcutaneous delivery mechanism (6), a pump for pumping liquid from the internal reservoir to the subcutaneous delivery system, and a liquid filling mechanism (12) configured for injecting liquid from an external vial (16) or reservoir into the internal reservoir. The liquid filling mechanism comprises a filling port (14) and a valve mechanism (18) selectively operable to: open a first fluid path (54) extending from the filling port to the internal fluid reservoir and close a second fluid path (56) extending from the internal reservoir to the subcutaneous delivery member, or close the first fluid path and open the second fluid path. The valve mechanism comprises a valve housing (48) fixedly mounted in relation to a housing of the drug delivery device and a valve stem (50) rotatably received within the valve housing, whereby the first fluid path and the second fluid path are selectively operated by the rotational position of the valve stem in relation to the valve housing, such that when the valve stem is in a first position, the first fluid path is open while the second fluid path is closed, and when the valve stem is in a second position, the second fluid path is open while the first fluid path is closed.

Disclosed is a medical device component for delivering medication fluid to a patient. The medical device component includes a fluid infusion device to regulate delivery of medication fluid, a body-mountable base unit, and a top cover assembly that is removably couplable to the base unit and to the fluid infusion device. The base unit includes a cannula to deliver medication fluid under the control of the fluid infusion device, and a physiological analyte sensor to measure a physiological characteristic. The base unit also includes an electronics assembly electrically connected to sensor leads to obtain measurements in the analog domain, to convert measurements into digital sensor data, and to communicate conditioned digital sensor data to the fluid infusion device. The top cover assembly is configured to provide both fluid and electrical connections for the base unit, by way of an infusion tube having sensor conductors integrated therein or otherwise associated therewith.

A medical delivery device (3) comprises a rod element having a stem with a longitudinal axis and a first thread arrangement, a dosage member (34) comprising a second thread arrangement and a chamber body, a dial unit (31), and a coupling structure coupling the dial unit (31) to the dosage member (34). The stem of the rod element extends into the chamber body of the dosage member (34). In a dosing status of the medical delivery device (3), the first thread arrangement of the rod element engages the second thread arrangement of the dosage member (34). Further, in the dosing status, the rod element is movable along its longitudinal axis relative to the dosage member (34) by the first thread arrangement of the rod element and the second thread arrangement of the dosage member (34) travelling along each other such that a volume of a dosage chamber in the interior of the chamber body of the dosage member (34) is varied. Still further, in the dosing status rotation of the dial unit (31) applies a torsional force to the dosage member (34) via the coupling structure, which torsional force rotates the dosage member (34) such that the second thread arrangement of the dosage member (34) and the first thread arrangement of the stem of the rod element travel along each other. The coupling structure has an overload protection mechanism (313, 314, 322, 324) configured to prevent that the torsional force applied by the dial unit (31) to the dosage member (34) exceeds a predefined threshold force.

A device for administering a fluid can include a cylinder, a piston connected to a piston rod, and a tensioning device connected to the piston rod. The tensioning device includes a ramp which is rotatable via a motor, a ramp track, and a roller which is in contact with the ramp track and which is mounted rotatably in a driver. The driver can be connected to the piston rod via a joint. In a tensioning procedure, the ramp track is rotated such that the roller runs on the region of inclination as far as the second plateau and the piston is thereby moved to its rear end position. In a dispensing procedure, the ramp track is rotated until the roller runs over a transfer region and, on account of the tensioning, is accelerated toward the first plateau and, as a result, the piston is moved toward the an dispensing end.

A device for administering needle-free subcutaneous treatment to a patient comprises an actuator configured to deliver a plurality of volumes of a treatment at a plurality of locations on a body of the patient; at least one imaging device configured to detect a movement of the needle-free device from a first location on the body of the patient to a second location on the body of the patient; and a processor configured to determine the second location on the body of the device relative to the first location from the movement of the needle-free device relative to the first location on the body, the processor further configured to determine a volume of the plurality of volumes of the treatment to deliver to the body of the patient at the second location.

A fluid delivery device includes: a fluid-filled cartridge comprising an outlet; a syringe comprising a substantially cylindrical syringe barrel having an open end and a fluid dispensing end; and a plunger rod configured to be received within the open end of the syringe barrel. The plunger rod comprises: a first end having a sealing member provided in sealing engagement with an inner wall of the syringe barrel such that a first syringe chamber is provided between the first end of the plunger rod and the fluid dispensing end of the syringe barrel; a second end extending out of the open end of the syringe barrel and having a cartridge-receiving chamber having a connection mechanism positioned therein for connecting the outlet of the cartridge thereto. The plunger rod also includes a fluid channel extending from the connection mechanism to the first end of the plunger rod.

A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10).

The tensioning device (S) has a ramp (52) which is rotatable by means of a motor (12) and has a ramp track (53) extending along a helical line, wherein the ramp track (53) ascends from a first plateau along a region of inclination (S1, S2) to a second plateau and descends from the second plateau to the first plateau via a transition flank (46).

The tensioning device (S) furthermore has a roller (51) which is in contact with the ramp track (53) and is mounted rotatably in a driver (50), which is connected to that end of the piston rod (35, 135) which protrudes out of the cylinder (16, 116), and therefore, upon rotation of the ramp (52), the ramp track (53) runs below the roller (51), which thereby rotates, wherein the roller (51) has a support region (55) which rests on the region of inclination (S1, S2) of the ramp track (53), and at least one laterally adjoining side region (56, 57) which has a smaller outside diameter than the support region (55) and which does not rest on the region of inclination (S1, S2) of the ramp track (53), wherein, during rotation of the ramp, both the support region (55) and the side region (56, 57) come into contact with an edge (54) of the ramp track (53), said edge connecting the second plateau to the transition flank (46).