The electrochemical pump unit of mesh combined electrode of the present invention is connected to a drug injection container for operation, when it is connected to the power supply, the cathode (or anode) enters into electrochemical reaction with the electrolyte of the superabsorbent material layer through the mesh electrode to release a first gas, the first gas flows through the screen meshes of mesh electrode immediately without obstruction loss; the anode (or cathode) enters into electrochemical reaction with the electrolyte on the opposite side of superabsorbent material layer through the plane electrode to release a second gas, the second gas flows through the inter fibrous small space/channels of superabsorbent material layer and the screen meshes of mesh electrode; as the first gas and the second gas increase, the piston is pushed, and the medicament is pushed.

Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.

A therapeutic agent delivery system comprises a housing. A therapeutic agent delivery assembly is carried by the housing. The therapeutic agent delivery assembly comprises a chamber having a passageway. A therapeutic agent is carried in the passageway, and a needle is in communication with the passageway. The therapeutic agent delivery assembly may be translatable relative to the housing from a stowed configuration to a deployed configuration. Actuation of a user input may translate the therapeutic agent delivery assembly from the stowed configuration to the deployed configuration. An input restraint may be rotatable relative to the housing from a first rotational configuration to a second rotational configuration. In the first rotational configuration the input restraint may inhibit actuation of the user input, and in the second rotational configuration the input restraint may permit actuation of the user input.

An injector includes an encapsulating portion configured to encapsulate a substance intended for injection, a first application portion configured to combust ignition charge and discharge a combustion product thereby applying a primary ejection energy to the substance intended for injection that is encapsulated in the encapsulating portion, an energy accumulation portion configured to accumulate an energy to be further applied to the substance intended for injection, the energy being different from the primary ejection energy applied by the first application portion. The injector also includes a second application portion configured to release the energy accumulated in the energy accumulation portion by using the discharged combustion product thereby applying, as a secondary ejection energy, the released energy to the substance intended for injection. With this configuration, the substance intended for injection can be caused to suitably reach the target region without affecting the substance intended for injection to be ejected.

An injection device, for example, an auto-injector of any type, includes a sleeve configured to hold a medicament chamber. The sleeve may be sufficiently deformable such that it functions as a shock absorbing member to distribute the force exerted on the medicament chamber during use of the injection device.

A needleless injector includes a first switch and a second switch that is provided to an injector enclosure for activation of a driving part. The first switch is arranged to be slidable in a predetermined direction different from a contact direction of a palm of the user, in a first region on a side surface that is a part of a surface of the injector enclosure positioned on side of the user, the first region being covered by the palm of the user in a holding state of the user, and the second switch has an upper side surface with at least a part inclined toward the side of the user to be visible from the user in a holding state of the user, and is arranged on an upper side of the injector enclosure to be able to be pressed.

A needleless injector includes a housing part that includes an accommodating space and defines a flow path for ejection, a driving part that imparts ejection energy, and a plunger that defines the accommodating space and is disposed to move in the housing part by the ejection energy and pressurize a substance intended for injection. The plunger includes a weakened part that causes a part of the plunger to deform such that, when force applied to the plunger exceeds predefined force while the driving part is imparting the ejection energy with the accommodating space accommodating the substance intended for injection, a distal end of the plunger does not reach an inner wall surface at a deepest part of the housing part or force received by the inner wall surface falls within a predetermined range until the distal end of the plunger reaches the inner wall surface.

A needleless injector includes a housing part that has an accommodating space that accommodates the intended injection substance, a nozzle portion that defines a flow path for guiding the intended injection substance accommodated in the housing part to the ejection port, a driving part that imparts ejection energy for ejecting the intended injection substance, a pressurizing portion that pressurizes the intended injection substance accommodated in the accommodating space via a propellant disposed to move or deform in a predetermined direction inside the needleless injector by imparting the ejection energy, and a notification unit that, after the ejection energy is imparted by the driving part and the intended injection substance is delivered into the target region, makes a predetermined notification regarding a first timing for canceling a contact state between the ejection port and the surface of the target region to a user.

A pneumatic power pack for a medicament delivery device is presented having a pressurized gas container storing pressurized gas and an activation assembly for releasing the pressurized gas from the gas source. The activation assembly including a rupturer having a sharp end, an activator, and a rotator coupled with the activator and the gas container. The activator is configured to move from a first position toward a second position to causes a rotation of the rotator which then drives the gas source towards the sharp end of the rupturer to release the pressurized gas.

An apparatus includes a label configured to be coupled to a medicament delivery device. The label includes a first surface and a second surface. The first surface is configured to be coupled to an outer surface of the medicament delivery device. The second surface includes a textual indicia. The label further includes an electronic circuit system configured to output an electronic signal.