A pyrotechnic actuator mechanism comprises a cover member which includes a first wall member which is opposed to a release portion of an ignition unit, and a second wall member which is connected thereto and which has a free end portion embedded in a fixing member. When an ignition charge contained in the ignition unit is combusted, then the cover member is moved in the propulsion direction so that a predetermined closed space is expanded in the propulsion direction of a piston, and the movement of the cover member is regulated so that a state, in which the free end portion of the second wall member is embedded in the fixing member, is maintained at a maximum propulsion position of the cover member. Accordingly, the residue, which is produced by the combustion of the ignition charge, is preferably suppressed from being discharged or emitted to the outside.

A needleless injector pressurizes a substance to be injected having an ejection pressure defined as a pressure of the substance to be injected ejected through an ejection port. The ejection pressure is raised to a first peak pressure after pressurizing is started, is lowered to a pressure lower than the first peak pressure afterward, and then is raised to a second peak pressure again. An on-completion reached depth that is an on-completion reached depth of the substance when the pressurizing portion completes pressurizing is adjustable, the on-completion reached depth being increased along with increase of the first peak pressure and being increased along with reduction of a length between peaks from a first timing at which the ejection pressure reaches the first peak pressure to a second timing at which the ejection pressure reaches the second peak pressure.

An autoinjector (100′) for expelling a single dose of a drug from a held cartridge (600) comprising a piston (630). The autoinjector includes a needle shield (350, 380′) axially movable from an initial extended position via a triggering position to a trigger release position. The needle shield (350, 380′) is operatively coupled to a plunger release element (320′, 1320) cooperating with a plunger (310, 400) to define a releasable retaining mechanism that retains the plunger release element (320′, 1320) threadedly engaged with a base thread component (204′, 1204) in a predefined relative rotational and axial position and against rotational bias provided by an actuator (330). The needle shield (350, 380′) is configured for operating the retaining mechanism to release the retaining of the plunger release element (320′, 1320) and the base thread component (204′, 1204) from the predefined relative rotational and axial position upon the needle shield (350, 380′) being moved into the trigger release position.

A pyrotechnic drive device includes a housing (3) provided with a combustion chamber (5) having pyrotechnic material (15) as well as an activation device (13). The combustion chamber is delimited at least in an initial state on all sides by combustion chamber walls (3, 7, 13, 17, 33, 35) formed in at least one partial region by respective pressure-receiving surface or respective pressure-receiving element (17, 35). Each pressure-receiving impact of a pressure-receiving element (17, 35) is impacted after the activation of the pyrotechnic material (15) in such a way by the gas pressure generated in this manner that the pressure-receiving element (17, 35) is moved and/or deformed (17, 35) and/or a mechanical impulse is thus transmitted via the pressure-receiving element (17, 35) to an element to be driven (19) so that a connected substance (25) is transmitted. The residual volume of the combustion chamber (5), in which no pyrotechnic material (15) is provided in the initial state, is filled with a liquid, a gel-like or pasty filling material (21), and/or a soft, rubber-like material.

An apparatus includes a housing, an energy storage member, a carrier, a medicament container, and a delivery control mechanism. The housing defines a gas chamber configured to receive pressurized gas from the energy storage member to pressurize the gas chamber. The carrier has a proximal surface that defines a portion of the gas chamber. The medicament container is coupled to the carrier and has a distal end portion coupled to a delivery member. The medicament container contains a medicament and includes an elastomeric member that seals the medicament within the medicament container. The delivery control mechanism is coupled to a proximal end portion of the medicament container and includes a flow restriction member for regulating a pressure supplied by the gas chamber and entering into the medicament container that acts on the elastomeric member.

Chemical engines and processes for their use and construction are described. The chemical engines can provide powerful and compact devices, especially autoinjectors for the rapid, powered injection of viscous medicines. Novel formulations and designs of chemical engines and delivery technologies employing the chemical engines are described.

An auto-injector includes a drive assembly within a housing carrying a syringe including a needle adjacent an activation cap within the housing's distal end. The drive assembly includes a first chamber carrying a gas canister, a plunger within a second chamber coupled to the syringe, and proximal and distal chambers. The activation cap is pressed against a subject's skin to direct the drive assembly proximally to open an outlet of the canister to release pressurized gas into the first chamber, whereupon the gas enters the proximal chamber to generate a distal force to advance the drive assembly to direct the needle into the subject and enters the second chamber to advance the plunger to deliver agents from the syringe into the subject. After the plunger advances, the gas enters the distal chamber to generate a proximal force to retract the drive assembly to direct the needle back into the housing.

There is provided an applicator including: a first liquid flow path through which a first liquid containing fibrinogen passes; a second liquid flow path through which a second liquid containing thrombin passes; a confluence section in which the first liquid and the second liquid merge with each other to form a mixed liquid; and a gas flow path through which a gas for jetting the mixed liquid passes. At least part of a wall portion defining the confluence section is composed of a gas-permeable membrane that is impermeable to the mixed liquid and permeable to the gas.

The invention relates to a needleless injection device, comprising a firing chamber (11) for the needleless injection of a substance (25), having a firing chamber containing a pyrotechnic material and a gel-like medium, with which a substance, in particular an active substance, can be accelerated at high speed and injected in a needleless manner into a tissue or into a body by means of a membrane (15).

The invention also relates to a method for producing a needleless injection device of this type containing a firing chamber together with pyrotechnic material and filled with a gel-like medium, and use thereof.

A method is disclosed for state sensing and controlling of a multi-state drug delivery device. In some embodiments a power switch is reused as a state sensor. Optionally the state sensor may be toggled by user actions and/or the movements of parts of the device, for example needle and/or a protective element. Optionally, drug discharge and/or status indication is controlled in accordance with sensor output. In some embodiments control is by means of a processor. Alternatively or additionally, control is by means of simple physical circuits.