A dual-chamber syringe may include an end wall and a primary plunger. The primary plunger may include a primary stopper. The primary stopper may form a primary chamber with the end wall. A secondary plunger may be in mechanical association with the primary plunger. The secondary plunger may include a secondary stopper. The secondary stopper may form a secondary chamber with the primary stopper. A primary nozzle may extend from the end wall and may be in fluid communication with the primary chamber. A secondary nozzle may extend from the end wall and may be in fluid communication with the secondary chamber.

Provided herein are an injection device and a method of injecting a patient. The injection device includes a base portion including a body section and a control section, at least one bracket secured to the body section, an articulation element secured to the control section, and a pusher plate coupled to the articulation element, wherein the articulation element moves the pusher plate with respect to the base portion. The method includes positioning at least two syringes in the injection device, placing an injection end of the injection device in contact with an injection site on the patient, and activating the articulation element, wherein activating the articulation element moves the pusher plate towards the at least two syringes, depressing a plunger and dispensing a fluid from the at least two syringes.

The present disclosure relates to drug delivery devices, and in particular, to drug delivery devices configured to reconstitute a lyophilized drug powder into liquid form prior to delivery into a patients body. In some embodiments, such devices include a flexible drug reservoir having a proximal reservoir component storing a liquid diluent and a distal reservoir component storing a lyophilized drug powder, wherein the two compartments are separated by a frangible seal. A compression member may be positioned above the reservoir and held up by a releasable mechanism. When released, the compression member may be driven downwards to compress the proximal compartment so as to break the frangible seal and allow the diluent to mix with the drug powder and form a liquid drug mixture, and then to eject the liquid drug mixture from the reservoir.

A container assembly with improved mixing dynamics for mixing substances in preparation for injection by an injection device or for the dispersion of additives in the collection and analysis of biological samples is disclosed. In one configuration, the container assembly includes a first mixing element protruding into an interior of a container. With the container rotated about its longitudinal axis, the first mixing element forms at least one vortex which effectuates mixing of a first substance provided within the container interior and a second substance provided within the container interior.

A device and a method for adjustable quantitative injection of high-pressure gas are provided, wherein the gas may have a pressure of 5 MPa or more than 5 MPa. The gas may be directly communicated with a gas tank in the mechanism or an external gas source, flows through corresponding valves, and is charged into a predetermined or adjustable reservoir. Alternatively, the valve may be time-controllable, and does not need the reservoir. The gas is ejected through a nozzle selected based on depth or range of injection, wherein a one-way valve is disposed between the nozzle and the body to prevent contamination due to backflow. The manipulator can exert an appropriate force onto a target portion of a human for gas injection, and when the injection is done, a biasing member can automatically return the mechanism to its original state, ready for the next injection.

A prefilled syringe includes a tubular containment body extending along an axis between a front end element and a rear end element, a fixed plug and two sliding plugs. A bypass channel in the initial position of the syringe is between the first two plugs which form, together with a third plug at the end of the syringe plunger, a first containment chamber containing a first liquid substance and a second containment chamber containing a second solid or liquid substance. The fixed plug is in contact with the front end element and is provided with a non-through cavity offset with respect to the axis and facing towards the front end element.

The present invention provides a solution for zero-point adjustment of drug delivery devices, including twin chamber drug delivery devices with a single dose engine.

Automated injection system disclosed in this application advantageously provides physicians with a simplified interface for selecting fluid sources, such as saline, contrast, or a mixture of both, to inject at high pressures. The injector system may comprise a multi-use subassembly, a single-use subassembly, a fitting to fluidly connect the multi-use and single-use subassemblies, a hand held controller, a user interface, and an injector housing.

Disclosed is an auto injector and a method for administering a medicament. The auto injector comprising: a housing; a cartridge receiver; a drive module coupled to move a plunger rod configured to move a first stopper; a temperature sensor configured to provide a temperature signal indicative of the temperature of the medicament in the cartridge; a processing unit configured to: receive the temperature signal; control the drive module to move the plunger rod from a first plunger rod position to a mix plunger rod position wherein the movement from the first plunger rod position to the mix plunger rod position is based on the temperature signal.

Disclosed is a method for controlling an auto injector and an auto injector for administering a medicament from a cartridge having a first cartridge end and a second cartridge end and having a cartridge outlet at the first cartridge end, the cartridge comprising a cartridge compartment with a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament. The auto injector comprises: a housing; a cartridge receiver; a cartridge sensor; a drive module; an orientation sensor; and a processing unit.