A spring release mechanism for a drug delivery includes a fusible member to restrain a spring in a charged state. A heating element is utilized to selectively heat and sever the fusible member. When the fusible member is severed, the spring is allowed to discharge and drive the drug delivery device components operably coupled thereto.

An autoinjector and method of injection are described. A power spring causes rotation of a drive nut about the central axis of the autoinjector that, in turn, causes a middle screw to rotate in the same direction as the drive nut and also to move in the distal direction while pushing a center screw in the distal direction that pushes the syringe and needle. The center screw also pushes a plunger that pushes the fluid out of the syringe. After injection, a locked retract screw is freed and rotates in the same direction as the middle screw causing the syringe to retract the syringe into the housing.

The invention relates to an autoinjector for dispensing a liquid product, in particular a highly viscous medication, comprising: a housing, a product container, which is arranged in the housing and has a slidable piston, wherein the piston can be slid in a dispensing direction in order to dispense the product contained in the product container, a forward drive element, which acts on the piston as the product is being dispensed, a first spring, which is preloaded such that the product can be dispensed from the product container by the sliding of the forward drive element and the piston, and a rotation element, which is operatively coupled to the forward drive element, wherein the first spring acts on the rotation element in such a way that the rotation element is set into rotation in order to dispense the product, wherein the rotation element or the forward drive element has a thread having a variable pitch.

An injection device, method, and system for drug delivery includes a primary container for storing a drug, the container having a stopper movably disposed in the container for expelling the drug, an injection drive mechanism comprising a plunger for acting on the stopper and an energy source for exerting a force on the plunger to cause the plunger to act on the stopper to expel the drug, the force causing the plunger to accelerate to a velocity prior to acting on the stopper, and a damping mechanism for reducing the velocity of the plunger prior to acting on the stopper. The damping mechanism can include a dashpot or an energy absorbing material associated with the plunger. Alternatively or additionally, the damping mechanisms can include absorbing material disposed between support members of an outer casing of the injection device and the primary container.

An injection device for receiving a syringe therein and for delivering a dose of medicament from the syringe, the injection device including: a driver mechanism retainable in a primed state and releasable from the primed state for driving one or more features of the injection device forwards, a trigger mechanism including a ramped surface engaged with the driver mechanism to retain the driver mechanism in the primed state, the trigger mechanism being configured on actuation thereof to withdraw the ramped surface from engagement with the driver mechanism for release thereof.

An autoinjector including a plunger for engaging with the bung, a collar located around the plunger, an insertion spring biasing the collar relative to the rear of the device, and a delivery spring biasing the plunger relative to the collar. The device further includes a stop feature defining the limit of axial movement of the syringe body through the housing, and a collar release mechanism for releasing the collar from the rear of the device to commence insertion and a plunger release mechanism for releasing the plunger from the collar while substantially preventing rearward axial movement of the collar, following insertion, to commence delivery of the medicament. Following release of the plunger from the collar, the plunger is configured to move axially and rotationally relative to the collar, the direction of rotation being changed one or more times with axial movement of the plunger.

An autoinjector having a body (1) receiving a reservoir (S) containing fluid and a piston (P); a piston rod (5) movable by an injection spring (8) between a primed position and an injection position; and a visual, audible, and/or tactile indicator for indicating the autoinjector may be removed from the injection site. The autoinjector including a retarding system for delaying actuation of the indicator relative to the end of injection, and including a dashpot (16) containing a fluid, a piston (19) in the dashpot, the dashpot or the piston movable in the body during actuation of the retarding system with the other stationary relative to the body, resulting in the fluid moving out from the dashpot through a flow passage (161; 195) to brake movement.

An injector device includes an elongate housing configured to receive container of medicament. The injector device also includes a needle sleeve mounted within the housing and moveable between an extended position in which the needle sleeve at least partially extends from the distal end of the housing, and a retracted position in which the needle sleeve is received further within the housing than in the extended position. The injector device also includes a release mechanism configured to control actuation of a piston rod. The release mechanism includes a rotatable member disposed within the housing and in cooperating engagement with the needle sleeve such that movement of the needle sleeve from the extended position to the retracted position causes the rotatable member to rotate within the housing from a first position to a second position.

A piston rod unit for a device for administering a medical substance delays a release of a mechanism of the device and includes an outer piston rod with a hollow space and a contact face for interacting with a stopper to discharge the substance, and an inner piston rod mounted in the outer piston rod to form a cavity at the distal end of the outer piston rod. The cavity contains a viscous fluid and a fluid displacement element located at least partially in the cavity that is operably or integrally connected to the inner piston rod. During relative movement between the fluid displacement element and the outer piston rod, fluid displacement causes movement resistance, such that mechanism release is delayed. The outer piston rod includes a distal, first piston rod part, comprising the contact face and the cavity, and a second piston rod part adjoining the first.

A training device (10) for training a user in the operation of an auto-injector that dispenses a medicament is described. The training device (10) comprises a housing (13), an actuation assembly (22) located within the housing (13), the actuation assembly (22) comprising a plunger (24) and a guide member (26), the plunger and the guide member defining, and connected by, a complementary first male profile and a first female profile. The plunger (24) is movable with respect to the guide member (26) along a first path defined by at least a portion of the first male or the first female profiles, the plunger (24) moving linearly between a start position and a finish position. The first path extends in a direction non-parallel to the linear movement of the plunger (24).