An autoinjector having a body (1) receiving a reservoir (S), the reservoir containing fluid and including a piston (P), such as a pre-filled syringe, and stationary in said body (1); a piston rod (5) that co-operates with the piston (P), the piston rod (5) movable between a primed position and an injection position in which the piston rod has moved the piston so as to inject the fluid into an injection site; and a visual, audible, and/or tactile indicator device for indicating to the user that the autoinjector may be removed from the injection site, the indicator device arranged at the rear end of the body (1), remote from the injection site. The autoinjector includes a retarding device to delay actuating the indicator device relative to the end of injection, the retarding device having an epicyclic gear train having at least one stage, and advantageously two stages.

A medicament delivery device including a first container having a delivery outlet at a front end thereof and a first stopper axially moveable in the first container, the first stopper defining and separating a first chamber and a second chamber in the first container, where the first chamber is axially forwards of the first stopper and the second chamber is axially rearwards of the first stopper. The medicament delivery device further includes a second container having a second stopper axially moveable in the second container, the second stopper defining and separating a third chamber and a fourth chamber in the second container, where the third chamber is axially forwards of the second stopper and the fourth chamber is axially rearwards of the second stopper, and where the third chamber has a vent outlet in fluid communication with a venting chamber.

Disclosed is an auto-injection apparatus for receiving a syringe, including: an outer casing enclosing a drive assembly and a syringe carrier configured to hold a barrel of the syringe, the syringe carrier being forward of the drive assembly and having stowed and delivery positions; an interlock extending between the syringe carrier and a syringe carrier housing at least partially surrounding the syringe carrier, the interlock preventing forward motion of the syringe carrier under the influence of an insertion actuator whilst in the stowed position. The drive assembly includes the insertion actuator for inserting a needle of the syringe into an injection site and a delivery actuator for driving a plunger into a barrel of the syringe which contains a substance for injection. The syringe carrier includes an interlock release mechanism which is configured to release the interlock such that the insertion actuator drives the syringe carrier forward.

A drug delivery device includes a housing defining a shell having a proximal and a distal end, a needle assembly at least partially disposed within the housing at the proximal end, a drive assembly at least partially disposed within the housing, and a damper mechanism at least partially disposed within the housing adjacent to the distal end. The housing further defines a longitudinal axis extending between the proximal end and the distal end. The needle assembly includes a syringe barrel containing a medicament and a needle or a cannula. The drive assembly is operably coupled to the needle assembly to urge the medicament through the needle or cannula. The damper mechanism is operably coupled to the drive assembly and the housing. Upon activating the drive assembly, the damper mechanism dampens an effect thereof.

An injection device and an injection device trainer for training a user to use an injection device. Each one of the injection device and the injection device trainer can include: a body portion; and an actuator positioned towards a proximal end of the body portion, the actuator moveable from a proximal position to a distal position; wherein the body portion comprises a body protrusion and the actuator comprises a latch that is arranged to couple with the body protrusion when the actuator is in the distal position, thus holding the actuator in the distal position.

Injection systems for drug delivery are disclosed. A system may include a container filled or fillable with a drug, a stopper movably disposed in the container, a plunger, an energy source outputting a force, a mechanical linkage operable to transmit the force output by the energy source to the plunger to cause the plunger to act on the stopper to expel the drug from the container, and a trigger member. The system may have pre-injection state where the trigger member inhibits actuation of the mechanical linkage, an injection state where the trigger member permits actuation of the mechanical linkage, and a post-injection state where the plunger is stationarily positioned in an end-of-dose position. The system may be designed to limit the number of components included in various force transmission loops present in the pre-injection, injection, and/or post-injection states.

Disclosed is an injection device including a body for receiving a syringe, a firing mechanism including a reaction component, a plunger configured to be axially displaced in a forward direction relative to the reaction component, and a drive spring located between the reaction component and the plunger for driving the plunger forwards upon activation of the injection device, wherein the reaction component provides a reaction surface for the drive spring. The device further includes a locking mechanism for locking the reaction component in a first axial position within the body, the locking mechanism being configured to release the reaction component upon a predefined forward movement of the plunger thereby allowing the reaction component to be driven in a rearward axial direction by the drive spring until it impacts against the body or a component secured to the body to thereby emit an audible indication of an end of dose.

Disclosed is an injection device for receiving a syringe therein and for delivering a dose of medicament from the syringe, the injection device including: an insertion driver configured to drive the syringe forwards within the injection device for inserting a needle of the syringe into an injection site; an interlock mechanism configured to retain the insertion driver in a primed state and, when actuated, to allow the insertion driver to drive the syringe forwards; and an interlock actuator moveable between a stowed position and an operable position and configured on movement from the stowed position to the operable position to couple to an actuation system such that movement from the operable position back towards the stowed position actuates the interlock mechanism.

Disclosed is an injection device for delivering a medicament from a syringe contained within a housing, the device being configured to move the syringe through the housing to cause insertion of a needle of the syringe into a user's skin and move a syringe bung through a syringe body, delivering medicament through the needle. The device includes: a plunger engaging the bung; a sleeve around the plunger; an insertion spring biasing the sleeve to the housing; and a delivery spring biasing the plunger to the sleeve. A release mechanism releases the sleeve from the housing to commence insertion and release the plunger from the sleeve, following insertion, delivering medicament. A velocity regulator regulates the plunger upon release and disengages during delivery, and includes a screw thread associated with the sleeve or plunger and one or more thread engaging members formed on the other of the sleeve and the plunger.