An injection device (100) including a tubular body (3) within which a cartridge is inserted (10) equipped with a bottom (14) and a back chamber (8) containing one first substance (SI). The device (100) also has a front chamber (9) containing one second substance (S2) intended to be mixed inside the tubular body (3) with the first substance (SI) to reconstitute the injectable substance (S). The device (100) is characterized in that the cartridge (10) has a flexible body (13) suitable for tearing as a result of the increase of pressure inside the cartridge (10) in order to put in communication the back chamber (8) with the front chamber (9) and to allow the reconstitution of the injectable solution (S).

A method for creating a sterile connection with a fluid in a container. The container has a sealing member sealing a first end of the container, and a barrier sealing a chamber in fluid communication with the sealing member. The method includes providing a valve sleeve assembly that includes a flexible sleeve having a barrier portion at an end of the flexible sleeve, a hollow first penetrator disposed within the flexible sleeve, and a hollow second penetrator at least partially disposed within the first penetrator. An interior of the flexible sleeve is sterile. The method also includes piercing the barrier portion and the barrier with the first penetrator, and displacing the second penetrator relative to the first penetrator and the sealing member to pierce the sealing member and establish the sterile connection with an interior of the container.

A drug delivery device (1), comprising a delivery unit (3) including a drug container (6), a liquid flow system (7), a pressurized gas source, and a casing (9) enclosing therein the drug container, the pressurized gas source and at least a part of the liquid flow system, the drug container comprising a barrel portion (6a) and a plunger (12) slidably mounted within the barrel portion and sealing the drug (78) within the container at one end of the barrel portion, the drug container being contained within a container receiving cavity (75) of a container casing portion (38) of the casing (9) and the container receiving cavity is fluidically interconnected to a fluid outlet (31) of the pressurized gas source in a gas tight manner, the pressurized gas source configured to supply pressurized gas in the container receiving cavity (75) thus applying pressure on a back end (73) of the plunger for delivery of the liquid drug. The drug delivery device further comprises a pressure sensor (80) fluidically coupled to the container casing (38) for measuring a pressure within the container casing (38), the pressure sensor connected to an electronic control system (47) configured to measure a pressure detected by the pressure sensor over time and to determine from the pressure measurement over time a position of the plunger over time, including a stop in movement of the plunger either due to occlusion in the drug delivery flow system or an end of travel of the plunger within a container corresponding to a container empty position.

A fluid discharge device for discharging a fluid has at least one release device for releasing the fluid from a fluid storage container. In addition, the fluid discharge device has a spring, which is tensioned between the release device and a force sensor, and which is designed to exert a restoring force on the force sensor with the releasing of the fluid. Finally, the fluid discharge device has the force sensor, which is designed to detect the restoring force acting on the force sensor with the releasing of the fluid.

A auto-injector device having a housing (212, 214), a cartridge for containing a medicament, a first needle tip (230) arranged to penetrate said cartridge, a second needle tip (230) for injecting said medicament into a target, said first and second needle tips being in fluid communication, a plunger rod (242) to move said cartridge so as to be pierced by said first needle tip, said plunger rod (242) having a recess (270) in an end thereof, the improvement comprising a battery (258), a printed circuit board (250) electrically communicating with said battery, an electrically conductive element (274) having a first end in electric communication with said battery (258) and printed circuit board (250), a second end within said recess (270) in said plunger rod (242), said second end being electrically insulated, a coil spring (246) surrounding said electrically conductive element and being spaced therefrom, the arrangement being such that when said plunger rod (242) is activated, said second end of said electrically conductive element is released from said recess (270) in said plunger rod (242) and contacts said coil spring (246) to complete an electric circuit.

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

A drug delivery system includes a drug containing device and a drug delivery device. The drug containing device includes a chamber carrying a fluid drug and an outlet in fluid communication with the chamber. A first closure initially inhibits the fluid drug from exiting the drug containing device via the outlet. The drug delivery device includes a fluid passageway and a stem having an inlet in fluid communication with the fluid passageway. The stem displaces the first closure from the outlet and enters the outlet to provide fluid communication between the chamber and the fluid passageway and thereby facilitates delivery of the fluid drug to the drug delivery device. A second closure is coupled to the stem, and the second closure engages the first body at the outlet when the stem enters the outlet to inhibit the fluid drug from exiting the drug containing device around the stem.

A mixing syringe, including: a barrel; a hollow plunger disposed inside the barrel, the hollow plunger having a stopper disposed on a distal end thereof and an open proximal end; a flexible container disposed inside the hollow plunger, the container containing a first material; a metering rod adapted to be inserted in the open proximal end of the hollow plunger so as to enclose the container therein, the metering rod adapted to be advanced within the hollow plunger from the open proximal end to the distal end thereof in predetermined increments.

A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can include a spring coupled to a plurality of force transfer elements. The force transfer elements can have a variety of shapes and configurations.

A disposable pre-filled syringe has a protecting tube, a medication filling tube, a separating plug, a pushing module, and a needle module. The medication filling tube is made of chemically inert material and is mounted in the protecting tube. The separating plug is mounted in an end of the medication filling tube. The pushing module is slidably inserted into the medication filling tube opposite to the separating plug. The needle module is mounted on an end of the protecting tube.