A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments, and a fitment. The first compartment contains at least a first constintuent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

Implementations of the present disclosure are directed to a sealing of a medicament reservoir for a drug delivery device. The drug delivery device includes a reservoir, a stopper and a sealing system. The reservoir includes a wall defining a distal end, a proximal end, and a proximal closure. The stopper is configured to expel a portion of a medicament stored within the reservoir by moving within the reservoir in a direction from the distal end to the proximal end, such that a stopper position is indicative of an amount of the medicament within the reservoir. The sealing system is configured to form a liquid tight seal between the proximal closure and the injection needles such that expelling the portion of the medicament comprises directing substantially all of the portion of the medicament from the reservoir into the injection needles.

A drug reservoir comprises of a housing having a proximal end and a distal end, wherein the housing is configured to hold a medicament; and a removable feature disposed on at least one of the proximal end and the distal end, wherein the removable feature covers at least in part one of the proximal end and the distal end.

Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a subject. The present disclosure comprises apparatus for the controlled administration of the therapeutic agent through an orifice to the subject, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes.

A drug delivery device comprising a first module comprising a zinc-air cell located at one end of the first module, a second module for attachment to the one end of the first module and comprising electronics, and activation means for activating the zinc-air cell and being designed such that at least one air hole is created in an air tight sealing of the zinc-air cell when the second module is attached to the one end of the first module.

The present disclosure relates to drug delivery devices, and in particular, to drug delivery devices configured to reconstitute a lyophilized drug powder into liquid form prior to delivery into a patients body. In some embodiments, such devices include a flexible drug reservoir having a proximal reservoir component storing a liquid diluent and a distal reservoir component storing a lyophilized drug powder, wherein the two compartments are separated by a frangible seal. A compression member may be positioned above the reservoir and held up by a releasable mechanism. When released, the compression member may be driven downwards to compress the proximal compartment so as to break the frangible seal and allow the diluent to mix with the drug powder and form a liquid drug mixture, and then to eject the liquid drug mixture from the reservoir.

A deformable cartridge for an injection device of an injectable solution has a cartridge body having a first containment chamber of a first component of the injectable solution, having a first compression-deformable wall, a second containment chamber of a second component of the injectable solution, having a second compression-deformable wall to allow the second component to be transferred from the second containment chamber to the first containment chamber, a separation device interposed between the first and the second containment chambers and having a device body. A fluidic communication duct is defined in the device body. The deformable cartridge assumes a first operating configuration in which the fluidic communication duct is not crossable by the second component and a second operating configuration in which the fluidic communication duct is crossable by the second component. A needle holder component is fixed to the cartridge body and fluidly connected to the first containment chamber which is interposed between the needle holder component and the separation device.

The present disclosure provides methods for lowering LDL-C levels in patients with homozygous familial hypercholes-terolemia (hoFH), the method comprising administering to the patient a pharmaceutical composition comprising a PCSK9 inhibitor. In certain embodiments, the PCSK9 inhibitor is an anti-PCSK9 antibody such as the exemplary antibody referred to herein as mAb316P.

A device for intraosseous injection is provided which can accurately, quickly, and safely introduce desired fluid into a patient's bone marrow. The intraosseous injector includes a housing, a container located within the housing, a hollow needle, and a valve. The intraosseous injector may further include a release mechanism comprising a bone probe needle and a movable release member. The intraosseous injector may include a depth limiter mechanism operable to limit a depth of penetration of the needle relative to a surface of a bone. A method for intraosseous injection is also provided.