The novel medicament devices comprise a housing that preferably contains a preloaded, conventional syringe with medication. Both trained and untrained users may administer an injection safely and conveniently to themselves or others in myriad settings. Certain of the disclosed embodiments rely on the user's manual action to insert the needle. Only after the needle is fully inserted is the medicament delivered, resulting in a safer injection. After use, the devices include a locking mechanism that locks a spring-loaded sheath in place around the needle for protection. As a common syringe is utilized, engineering and production issues of conventional automatic injectors are avoided.

Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.

A device and method for aspirating graft tissue and delivering the graft tissue to a target delivery site (for example, when performing Descemet's membrane endothelial keratoplasty). In one embodiment, an injector comprises a cylinder and a plunger at least partially located within the cylinder, the plunger being rotatably advanceable and retractable within the cylinder. In one aspect of the embodiment, rotating the plunger in a first direction within the cylinder controllably aspirates a graft tissue into the injector and rotating the plunger in a second direction opposite the first direction controllably ejects the graft tissue from the injector.

A syringe assembly for use in medication delivery includes a syringe barrel having a needle at a distal end of the barrel; a body defining an enclosure, said barrel extending at least partially within said enclosure; a safety shield for the needle, longitudinally movable with respect to the body between a retracted position and an activated position; a spring urging said safety shield towards said activated position; and a first locking mechanism for locking the safety shield in the retracted position. The first locking mechanism is manually releasable by a user so as to let the safety shield reach the activated position. The first locking mechanism includes a trigger button on the body, and a first engaging area on the safety shield; the trigger button presenting a default state and a depressed state. The first locking mechanism is configured such that when the safety shield is in the retracted position and the trigger button is in the default state, the trigger button engages the first engaging area and when the trigger button is in the depressed state, the trigger button does not engage the first engaging area.

A dual chamber, sequential delivery syringe facilitates selective drug mixing, dosing, and administration through catheters or other vascular accessing devices (VADs), as well as post-administration flushing of catheters with a single syringe instrument. A syringe barrel incorporates an outlet, such as a Luer connector, a variable-volume, primary fluid chamber, and a secondary chamber that is pre-filled with fluid. A plunger manipulated, telescoping actuator, in conjunction with a medication stopper disposed within the barrel interior, form a valve for selectively isolating the secondary fluid chamber from fluid communication with the primary fluid chamber and/or the outlet of the syringe barrel. Valve opening is accomplished automatically by continuous advancement of the plunger.

The present disclosure is directed to a device for screening pre-filled syringes configured to determine whether a stopper position within each syringe falls within an acceptable tolerance prior to final assembly of a syringe into a corresponding autoinjector device, thereby ensuring proper fit of the syringe within the autoinjector device and further ensuring accurate delivery of a desired dose of fluid from the syringe during operation of the autoinjector.

The present invention provides a next-generation pre-filled syringe having a reduced number of components and requiring reduced costs and including a safety mechanism for preventing needlestick injuries. In the syringe of the present invention, elastic engagement members 11 of the cover 6 engage the injection needle 5 so as to prevent the injection needle 5 from being withdrawn from the elastic engagement members 11 of the cover in a retracted state toward the base end, and the elastic engagement members and injection needle are disengaged from each other as the elastic engagement members 11 are diametrically expanded/deformed. Further, the plunger 4 includes an integrated deformation-prevention part 41 covering the outer peripheries of the plurality of elastic engagement members 11 so as to prevent the elastic engagement members 11 and the injection needle 5 from being disengaged from each other as the elastic engagement members 11 are diametrically expanded/deformed.

An injector for delivering a medicament includes an outer sleeve, an inner sleeve, and a syringe. The inner sleeve is disposed partially within the outer sleeve. A plunger rod of the syringe is engaged with the outer sleeve in a fixed spatial relationship such that the plunger rod and the outer sleeve translate as a unit. The outer sleeve is configured for axial translation relative to the inner sleeve from a first configuration wherein the inner sleeve extends from the outer sleeve a first distance to a second configuration in which the inner sleeve extends from the outer sleeve a second distance that is less than the first distance. Further, in a third configuration the inner sleeve extends from the outer sleeve a third distance that is greater than the second distance and the inner sleeve is restricted from axially translating with respect to the outer sleeve.

A method of controlling flow through a flexible tube includes providing a pinch clamp mechanism including a pinching element and a pinching surface configured to apply a force on the flexible tube when the flexible tube is positioned between the pinching element and the pinching surface. The method also includes displacing the pinching element relative to the pinching surface with a mechanical drive unit and biasing the pinching element toward the pinching surface with a spring.

An injector for delivering a medicament includes an outer sleeve, an inner sleeve, and a syringe. The inner sleeve is disposed partially within the outer sleeve. A plunger rod of the syringe is engaged with the outer sleeve in a fixed spatial relationship such that the plunger rod and the outer sleeve translate as a unit. The outer sleeve is configured for axial translation relative to the inner sleeve from a first configuration wherein the inner sleeve extends from the outer sleeve a first distance to a second configuration in which the inner sleeve extends from the outer sleeve a second distance that is less than the first distance. Further, in a third configuration the inner sleeve extends from the outer sleeve a third distance that is greater than the second distance and the inner sleeve is restricted from axially translating with respect to the outer sleeve.