Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

Embodiments of a syringe-based device for delivering fluid include a housing, a port, the port being positioned at about the distal end of the housing, a plunger assembly, the plunger assembly including, a plunger seal, a valve, and a cannula, a first fluid reservoir, where the first fluid reservoir retains a first type of fluid, a syringe including a syringe body, a syringe port, a plunger, and a second fluid reservoir, the second fluid retaining a second type of fluid, and where the syringe transitions from a first configuration in which a first portion of the first fluid type is delivered through the port, to a second configuration in which the second type of fluid in the second fluid reservoir is delivered through the port, to a third configuration in which a second portion of the first fluid type is delivered through the port.

The present disclosure relates to a stopper configured to be positioned inside a barrel of an injection device for injecting at least one composition, said stopper including: a gasket including a proximal end, a distal end, a lateral wall, and a through hole extending from the proximal end to the distal end, an insert inserted in the through hole, wherein the stopper is adapted to deform between: a closed configuration wherein the gasket cooperates with the insert to hermetically close the through hole, for preventing flow of the composition between the proximal end and the distal end of the gasket, and an open configuration wherein the gasket cooperates with the insert to open a fluidic pathway in the through hole between the proximal end and the distal end of the gasket for allowing flow of the composition

A medicament delivery device includes a distal housing part; a proximal housing part for a container; a drive mechanism in the distal housing part that includes a plunger rod; and an auto mixing mechanism. The housing parts are movable from a first position, in which the housing parts are partially extended relative to each other, to a second position, in which the housing parts are partially retracted relative to each other. The auto mixing mechanism is configured to hold the housing parts in the first position and to lock the housing parts in the second position, and includes a mixing force member operably arranged between the housing parts such that manual activation of the auto mixing mechanism enables the mixing force member to cause the housing parts to move from the first position to the second position. The plunger rod acts to mixing a medicament in the container.

A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments, and a fitment. The first compartment contains at least a first constintuent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

A discharger comprising a housing, a piston arranged inside the housing and being movable between a first piston position and a second piston position, a hollow cylindrical container inside the housing, the container being movable between a first container position and a second container position, a first compartment defined within the housing, a second compartment defined within the container, an axially extending passage in the interior of the piston and in communication with the first compartment and a peripheral opening of the piston in the region of a proximal end of the piston, a sealing element configured to prevent communication between the second compartment and the peripheral opening of the piston when the container is in a first container position, and a releasable retaining device configured to retain the piston in a piston first position until the container has reached a second container position.

The invention relates to a cover for housing a syringe, an assembly comprising such cover, a pen-injector comprising such assembly and a method for forming a pen-injector.

A manufacturing method of two-chamber type combined container-syringe including: a vacuum plugging process (S2) of eliminating air bubbles from the dissolving solution of the dissolving solution-filled cartridge and sealing the dissolving solution with a middle stopper after the dissolving solution filling process (S1); a vacuum plugging process (S2) has a first cooling processing (S21) of cooling the inside of a vacuum plugging equipment in which a dissolving solution-filled cartridge is disposed to a cooling temperature that does not freeze the dissolving solution, a first decompression processing (S23) of decreasing a pressure inside the vacuum plugging equipment while the vacuum plugging equipment maintains the cooling temperature after the first cooling processing (S21), and a middle stopper pushing processing (S24) of pushing the middle stopper downward and bringing the middle stopper into contact with the dissolving solution after the first decompression processing (S23). The dissolving solution can be easily filled in a bubble-free state in the two-chamber type combined container-syringe.

A multi-chamber injection device includes multiple syringes. The multiple syringes may be arrayed in a circular, linear, or other format. In some implementations, a needle, port, or similar may be shared by all the syringes in configuration that allows only one syringe to deliver contents at a time while blocking the other syringes from delivering their respective contents. In some implementations, the syringes may be all stored in the same container. One or more of the chambers of a multi-chamber injection device may be preloaded with medication. Different medications may be loaded into different chambers. The medications may be selected to treat the same medical condition.

A medicament delivery device (100) for delivery of medicament through a cannula (132) from a cartridge (10), the device comprising a first container (11) for storage of a first substance, a second container (12), and valve means for closing a distal end of the second chamber (12), the second container (12) being arranged coaxially with respect to the first container (11), a mixing element (304) being provided for causing displacement of the second substance into the first container (11) through the valve means in a mixing stroke, a release element being provided for holding the mixing element (304) in an initial position and being operable to release the mixing element (304) to initiate the mixing stroke, there being a needle shroud (400) for shrouding the cannula, and removal of the needle shroud (400) from the cannula (132) causing operation of the release element.