An ingestible jet injection device for introducing a fluid drug formulation into a gastrointestinal wall portion of a living mammal subject comprises an adaptive nozzle, a drug reservoir in flow communication with the nozzle, and a drive arrangement for pressurizing the fluid drug, the drive arrangement being actuatable from an initial state to a released state. The nozzle comprises an elastomeric nozzle member with an axially fixed, radially distensible outlet channel, the channel being fully collapsed when the drive arrangement is in the initial state thereby providing a sealed outlet from the reservoir. The channel opens when the drive arrangement is actuated and the pressure in the reservoir exceeds a given opening pressure level thereby creating a collimated jet stream of fluid drug adapted to penetrate a gastro-intestinal mucosal surface, the cross-sectional area of the channel adapting in response to variation in reservoir pressure.

Systems and methods to allow for a needleless nozzle to attach to a standard syringe. The standard or typical syringe insertable into a housing. The housing including an actuator to transfer generated mechanical energy to a plunger of a standard syringe to deliver a specified injectable via needleless injection. In embodiments, a needleless injection system includes a syringe having a barrel and a needleless nozzle. The barrel is designed or reinforced to withstand pressure necessary for needleless injection without deformation of the barrel. The needleless nozzle is configured to removeably attach to a proximal end of the barrel and to facilitate needleless injection of an injectable.

The present invention provides a microjet drug injection device equipped with a backflow prevention valve, the microjet drug injection device comprising an upper housing, a lower housing, a partition, and the backflow prevention valve provided with a slit through which a drug passes at a lower end and allowing the drug to move only towards an injection nozzle.

A needleless syringe having a multi-nozzle and a manufacturing method therefor are proposed. The needleless syringe injects a drug solution through an injection nozzle by expanding a pressure-generating liquid by means of energy generated from a pressure-generating unit, wherein precise branch channels are stably formed so as to inject drugs into a plurality of parts by using multiple injection nozzles. Further, the present disclosure has advantages in that: one energy-generating unit is used and thus nozzles can be densely arranged with a small distance therebetween; when several injections into an affected part are needed, the treatment time can be shortened using multiple injection nozzles; and an inner chamber is inserted into and coupled to or is insert injection-molded in an outer chamber so that more stable and precise branch channels can be formed, and thus multiple drugs can be stably injected into an affected part through multiple injection nozzles.

The present invention provides a drug delivery device (2, 3; 102) for sequential administration of substances, comprising a first variable volume reservoir (40a; 140a) holding a first substance and comprising a first outlet (41 a, 141 a) and a first displaceable wall (43a; 143a), a second variable volume reservoir (40b; 140b) holding a second substance and comprising a second outlet (41 b; 141 b) and a second displaceable wall (43b; 143b), a first wall actuation structure (65a, 70a, 75a, 77a; 177a) activatable to move the first displaceable wall (43a; 143a) and thereby expel a dose of the first substance through the first outlet (41 a; 141 a), a second wall actuation structure (65b, 70b, 75b, 77b; 177b) activatable to move the second displaceable wall (43b; 143b) and thereby expel a dose of the second substance through the second outlet (41 b; 141 b), and a drive structure (90; 190) for activating the first wall actuation structure (65a, 70a, 75a, 77a; 177a) and the second wall actuation structure (65b, 70b, 75b, 77b; 177b). The drive structure (90; 190) performs a predetermined movement during one sequential administration of the first substance and the second substance, the predetermined movement comprising a first part movement followed by a second part movement, and is configured to activate the first wall actuation structure (65a, 70a, 75a, 77a; 177a) during the first part movement and to activate the second wall actuation structure (65b, 70b, 75b, 77b; 177b) during the second part movement.

Disclosed is drug delivery system for effectively administering a drug into a human or animal body tissue. The microjet drug delivery system includes (a) a microjet injector including: a pressure chamber partially sealed by an elastic membrane and containing a pressure-inducing liquid fluid-tightly filled therein; and a drug chamber adjacent to the pressure chamber, wherein the elastic membrane is disposed between the pressure and drug chambers, wherein the drug solution is contained in the drug chamber, wherein the drug chamber has a micro-nozzle partially defined in a wall thereof for ejecting the drug solution out of the drug chamber; (b) a laser generator for generating a laser beam and emitting the laser beam out of the laser generator, wherein the laser generator is configured by irradiating the laser beam into the pressure-inducing liquid in the microjet injector, thereby generating a bubble in the pressure-inducing liquid; and (c) a fractional laser filter module configured for splitting the laser beam incident from the laser generator into a plurality of fractional laser beams, each beam has a reduced diameter, and for irradiating the fractional laser beams. According to the microjet drug delivery system, the pre-ablating of the skin with the fractional laser beams to partially remove the stratum corneum may enable the drug microjet based injection to allow the drug to be effectively invaded into a skin tissue at the portion where the stratum corneum is partially removed and relatively softened.

An exemplary embodiment of the present disclosure can provide an injector including a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger member can include a trigger member having a retainer portion, and a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom and a trigger engagement member configured to engage the retainer portion of the trigger member in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation between the trigger engagement member and the retainer portion from the pre-firing condition to a firing condition in which the trigger engagement member is released from the retainer portion to allow the energy source to fire the ram.

A needleless injector includes a first switch and a second switch that is provided to an injector enclosure for activation of a driving part. The first switch is arranged to be slidable in a predetermined direction different from a contact direction of a palm of the user, in a first region on a side surface that is a part of a surface of the injector enclosure positioned on side of the user, the first region being covered by the palm of the user in a holding state of the user, and the second switch has an upper side surface with at least a part inclined toward the side of the user to be visible from the user in a holding state of the user, and is arranged on an upper side of the injector enclosure to be able to be pressed.

An apparatus may include a plunger and a substantially cylindrical body. The substantially cylindrical body may include an end portion having rounded edges and may define a cavity sized to receive the plunger. The substantially cylindrical body may include at least one opening extending from the cavity to an external surface. The at least one opening may a substantially irregular shape. In some embodiments, the at least one opening may extend from the cavity through a nub to the external surface. The nub may have a rounded shape. In some embodiments, the substantially irregular shape may include one of a slit, an oval shape, an elliptical shape, an hourglass shape, a rectangular shape, and a diamond shape. In some embodiments, the opening may be part of a non-cylindrical fluid passage.

The present utility model provides an electrically powered needle-free injector (100), comprising: a needle-free injector body (120); and a needle-free injection end (130) extending distally from the needle-free injector body (120) for medicine administration, the needle-free injector body (120) comprises: a housing (3), an inside of which is divided into a pressurized injection chamber (123) and a motor chamber (124); a pressurized injection assembly (170) disposed within the pressurized injection chamber (123); a needle-free injector locking mechanism (180) at least partially disposed within the pressurized injection chamber; and a motor assembly (190) disposed within the motor chamber (124). The present utility model has a beneficial effect that it may provide a power source for the needle-free injector to electrically take medicine and inject by a built-in motor; it works reliably, is used conveniently, and has a small size.