Provided are a device whereby, during process of a process target such as a cell or the like, localized process of a process part is possible without inflicting damage due to heat, and rejoining and regeneration may proceed readily subsequent to process, and whereby an injection substance may be introduced efficiently; and a device for generating bubbles containing a plasma. Through the use of a localized ablation device employing a bubble jetting member having a core formed from a conductive material, a shell part formed from an insulating material, covering the core and including a section extending from the tip of the core, and a space formed between the extended section of the shell part and the tip of the core, a process target can be treated in localized fashion and without inflicting damage. By further providing an outside shell part at the outer periphery of the shell part, bubbles onto which a solution containing an injection substance has been adsorbed can be ejected, and the injection substance can be introduced during localized ablation of the process target. Additionally, by including a pair of electrodes formed from a conducting material, for generating a plasma in an inert gas, a liquid flow passage through which a liquid flows, and a microscopic flow passage for flow of an inert gas, an inert gas containing a plasma, and bubbles of inert gas containing a plasma, the liquid flow passage and the microscopic flow passage connecting at the downstream side from a section in which plasma is generated in the microscopic flow passage, bubbles containing a plasma can be generated, and can maintain a plasma state even in liquid, whereby therapy of biological tissue can be effected with the plasma.

A device for repetitive needleless injection of a liquid into a surface includes a handheld unit that includes at least a cell that is fillable with the liquid. A propulsion mechanism is configured to apply a sequence of pressure pulses to the liquid. Each pulse ejects a micro jet of the liquid from the cell via an orifice between the cell and the exterior of the handheld unit with a velocity that is sufficient to enable the micro-jet to penetrate into the surface. A reservoir is connected to the cell by a conduit to enable the liquid to flow from the reservoir to the cell to replace the liquid that is ejected in the micro-jet. A controller is configured to operate the propulsion mechanism repeatedly so as to eject the sequence of the micro-jets.

The present invention provides a microjet drug injection device equipped with a backflow prevention valve, the microjet drug injection device comprising an upper housing, a lower housing, a compartment, and a backflow prevention valve.

The described technology relates to a needleless syringe for injecting an injection objective substance into an injection target area. The needleless syringe includes a protruding member which is provided movably from a first position to a second position at which 1) a protruding length of a forward end of the protruding member from an end surface of a housing is shorter than a protruding length of the forward end at the first position and 2) the forward end and a discharge port can be brought in contact with the injection target area. The needleless syringe also includes a maintaining mechanism which maintains the protruding member at the first position and a power source circuit which applies a voltage to a driving unit when the protruding member having been maintained at the first position is moved to the second position. Accordingly, the unintended discharge from the syringe is appropriately avoided.

The invention relates to an instrument head, comprising: an exit opening (23); a first feed line (11) for the feed of a first fluid; a second feed line (12) for the feed of a second fluid; a reservoir (24) for storing the fluid fed via the second feed line (12); wherein the reservoir (24) is in fluid communication with the first feed line (11) and/or is adapted to be brought in fluid communication with the first feed line (11) via at least a valve (25) arranged in the instrument head, to deliver fluid stored in the reservoir (24) via the exit opening (23).

An injection guide globally aligns an injector to an angle selected for consistent subcutaneous delivery of an injectate, while locally aligning a patient's skin normal to the injection path at the location where the injection pierces the skin. This arrangement advantageously maintains controlled contact between an injector and a subject's skin in order to deliver the full, intended volume of injectate into the patient's subcutaneous layer while avoiding misdelivery into adjacent layers such as the patient's dermis or muscle.

An apparatus for transdermal injection includes a collet configured to transition between first and second states. In the first state, the collet receives a cartridge with a predetermined elongate shape. In the second state, an inner surface of the collet substantially conforms to the predetermined elongate shape of the cartridge such that expansion of the cartridge, when the cartridge is pressurized, is substantially uniformly opposed.

A minimally invasive skin treatment system includes a platform having a recessed area on its bottom and one or more injection ports orthogonal to its top, each injection port including a through-hole to the recessed area. The system includes an injection device including a needle slidably disposed in a selective port such that the needle passes into the recessed area and percutaneously through a dermis disposed within the recessed area. A nozzle is configured to discharge a fluid at a high pressure in a direction orthogonal to an axis of the needle and parallel to the top of the platform to cut create a plane of dissection within the subcutaneous tissue.

An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.